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NEMoCuRe SIGNED

Role of S-Nitrosylation of epigenetic modifiers in vascular regeneration

Total Cost €

EC-Contrib. €

Partnership

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NEMoCuRe project word cloud

Explore the words cloud of the NEMoCuRe project. It provides you a very rough idea of what is the project "NEMoCuRe" about.

modifiers humans edinburgh injured nuclear aorta activation lay cardiology toward matrone situ investigator biologist builds extensive rerio data structured laser interesting confirm morpholinos background nitrosylation extracts denvir reader proteins insights innate refine epigenetic tlr3 dorsal immune formal advantage candidate skills trigger inos crispr mutagenesis showing mass foundations tissues vascular injury mentor career msca disease excellent independent preliminary supportive cas9 plan genetically transition he regeneration cardiovascular site decipher modulate danio consist sciences nfkb spec university coursework strategies proteomic dr tissue lines mutated martin provocative describes track zebrafish knocked talented mentorship pharmacologically mechanisms transgenic prepare centre

Project "NEMoCuRe" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	195˙454.00

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Project objective

This MSCA-IF describes a career development plan to prepare Dr. Matrone to become an independent investigator. This program builds on Dr. Matrone’s background as a talented biologist in cardiovascular regeneration and will provide him with the skills to decipher the mechanisms of S-Nitrosylation of epigenetic modifiers during tissue regeneration in zebrafish (Danio rerio). These studies will lay the foundations for future studies that will be carried out by Dr. Matrone as an independent investigator. The project will be carried out at the Centre for Cardiovascular Sciences at the University of Edinburgh. Dr. Matrone’s mentor is Dr. Martin Denvir, Reader in Cardiology. Dr. Denvir is an excellent mentor with extensive experience in cardiovascular disease. The MSCA-IF will consist of structured mentorship, formal coursework, a provocative research project and a program of career transition. Dr. Matrone’s research proposal is based on supportive preliminary data. Changes in S-nitrosylation of epigenetic modifiers in response to injury will be assessed in nuclear proteins extracts from injured tissues and identified by mass spec-proteomic analyses. The most interesting and novel epigenetic modifiers will be further studied in vascular development and regeneration following laser injury in the dorsal aorta. Candidate proteins will be knocked out by CRISPR/Cas9 or knocked down by morpholinos and will be mutated by site-specific mutagenesis. Furthermore, Dr. Matrone will assess the role of the innate immune system and iNOS in S-nitrosylation of nuclear proteins (e.g. epigenetic modifiers). He will confirm and refine his preliminary data showing that the innate immune system and iNOS trigger tissue regeneration. He will pharmacologically and genetically modulate TLR3, NFkB and iNOS and will take advantage of transgenic lines to track changes in the immune system activation in situ. These studies may provide insights toward novel strategies for tissue regeneration in humans.

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The information about "NEMOCURE" are provided by the European Opendata Portal: CORDIS opendata.