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NEMoCuRe SIGNED

Role of S-Nitrosylation of epigenetic modifiers in vascular regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEMoCuRe project word cloud

Explore the words cloud of the NEMoCuRe project. It provides you a very rough idea of what is the project "NEMoCuRe" about.

situ    regeneration    morpholinos    excellent    cas9    tissues    proteins    mutated    supportive    centre    provocative    spec    trigger    genetically    proteomic    sciences    martin    formal    nfkb    aorta    transition    nitrosylation    denvir    data    skills    tlr3    preliminary    epigenetic    msca    zebrafish    injured    nuclear    career    extensive    mechanisms    background    danio    confirm    cardiology    independent    insights    talented    activation    reader    investigator    disease    laser    modifiers    inos    biologist    builds    transgenic    structured    lines    knocked    dorsal    cardiovascular    toward    track    innate    interesting    tissue    plan    vascular    mentorship    pharmacologically    mutagenesis    strategies    dr    humans    advantage    consist    matrone    injury    foundations    rerio    showing    university    he    candidate    immune    modulate    site    decipher    coursework    describes    extracts    lay    prepare    mentor    edinburgh    refine    mass    crispr   

Project "NEMoCuRe" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 195˙454.00

Map

 Project objective

This MSCA-IF describes a career development plan to prepare Dr. Matrone to become an independent investigator. This program builds on Dr. Matrone’s background as a talented biologist in cardiovascular regeneration and will provide him with the skills to decipher the mechanisms of S-Nitrosylation of epigenetic modifiers during tissue regeneration in zebrafish (Danio rerio). These studies will lay the foundations for future studies that will be carried out by Dr. Matrone as an independent investigator. The project will be carried out at the Centre for Cardiovascular Sciences at the University of Edinburgh. Dr. Matrone’s mentor is Dr. Martin Denvir, Reader in Cardiology. Dr. Denvir is an excellent mentor with extensive experience in cardiovascular disease. The MSCA-IF will consist of structured mentorship, formal coursework, a provocative research project and a program of career transition. Dr. Matrone’s research proposal is based on supportive preliminary data. Changes in S-nitrosylation of epigenetic modifiers in response to injury will be assessed in nuclear proteins extracts from injured tissues and identified by mass spec-proteomic analyses. The most interesting and novel epigenetic modifiers will be further studied in vascular development and regeneration following laser injury in the dorsal aorta. Candidate proteins will be knocked out by CRISPR/Cas9 or knocked down by morpholinos and will be mutated by site-specific mutagenesis. Furthermore, Dr. Matrone will assess the role of the innate immune system and iNOS in S-nitrosylation of nuclear proteins (e.g. epigenetic modifiers). He will confirm and refine his preliminary data showing that the innate immune system and iNOS trigger tissue regeneration. He will pharmacologically and genetically modulate TLR3, NFkB and iNOS and will take advantage of transgenic lines to track changes in the immune system activation in situ. These studies may provide insights toward novel strategies for tissue regeneration in humans.

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The information about "NEMOCURE" are provided by the European Opendata Portal: CORDIS opendata.

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