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NEMoCuRe SIGNED

Role of S-Nitrosylation of epigenetic modifiers in vascular regeneration

Total Cost €

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EC-Contrib. €

0

Partnership

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 NEMoCuRe project word cloud

Explore the words cloud of the NEMoCuRe project. It provides you a very rough idea of what is the project "NEMoCuRe" about.

biologist    cas9    innate    interesting    tissues    trigger    insights    humans    martin    career    confirm    nitrosylation    extracts    proteins    matrone    dr    activation    supportive    coursework    laser    rerio    plan    reader    aorta    transgenic    genetically    mass    consist    background    independent    regeneration    modifiers    decipher    tissue    advantage    msca    nuclear    centre    strategies    data    foundations    edinburgh    mutagenesis    crispr    mutated    investigator    immune    provocative    proteomic    transition    spec    cardiovascular    denvir    structured    vascular    prepare    injured    inos    formal    tlr3    injury    lay    mentor    sciences    skills    mentorship    track    talented    knocked    candidate    danio    preliminary    mechanisms    excellent    zebrafish    morpholinos    epigenetic    lines    extensive    describes    toward    disease    university    builds    modulate    nfkb    dorsal    situ    pharmacologically    refine    showing    he    cardiology    site   

Project "NEMoCuRe" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 195˙454.00

Map

 Project objective

This MSCA-IF describes a career development plan to prepare Dr. Matrone to become an independent investigator. This program builds on Dr. Matrone’s background as a talented biologist in cardiovascular regeneration and will provide him with the skills to decipher the mechanisms of S-Nitrosylation of epigenetic modifiers during tissue regeneration in zebrafish (Danio rerio). These studies will lay the foundations for future studies that will be carried out by Dr. Matrone as an independent investigator. The project will be carried out at the Centre for Cardiovascular Sciences at the University of Edinburgh. Dr. Matrone’s mentor is Dr. Martin Denvir, Reader in Cardiology. Dr. Denvir is an excellent mentor with extensive experience in cardiovascular disease. The MSCA-IF will consist of structured mentorship, formal coursework, a provocative research project and a program of career transition. Dr. Matrone’s research proposal is based on supportive preliminary data. Changes in S-nitrosylation of epigenetic modifiers in response to injury will be assessed in nuclear proteins extracts from injured tissues and identified by mass spec-proteomic analyses. The most interesting and novel epigenetic modifiers will be further studied in vascular development and regeneration following laser injury in the dorsal aorta. Candidate proteins will be knocked out by CRISPR/Cas9 or knocked down by morpholinos and will be mutated by site-specific mutagenesis. Furthermore, Dr. Matrone will assess the role of the innate immune system and iNOS in S-nitrosylation of nuclear proteins (e.g. epigenetic modifiers). He will confirm and refine his preliminary data showing that the innate immune system and iNOS trigger tissue regeneration. He will pharmacologically and genetically modulate TLR3, NFkB and iNOS and will take advantage of transgenic lines to track changes in the immune system activation in situ. These studies may provide insights toward novel strategies for tissue regeneration in humans.

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The information about "NEMOCURE" are provided by the European Opendata Portal: CORDIS opendata.

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