Opendata, web and dolomites


NeuroVU: Real-time Sensing in Microfluidic Models of the Neurovascular Unit

Total Cost €


EC-Contrib. €






 NeuroVU project word cloud

Explore the words cloud of the NeuroVU project. It provides you a very rough idea of what is the project "NeuroVU" about.

polymer    nor    microsystems    stoichiometry    conversions    stem    biology    gatekeeper    nvu    materials    cells    glass    polydimethylsiloxane    resistance    optimize    termed    monitoring    culture    thiol    pluripotent    brain    rely    tissue    chemistry    normal    prevalent    therapeutic    featuring    pharmaceutical    resident    overcome    disease    promise    supersede    unprecedented    human    metabolic    paradigm    fall    blood    pharmacodynamics    neurovascular    chemical    central    animals    continuous    epoxies    integrating    leverage    chip    biophysical    uniquely    neurovu    ene    hydrogel    components    ultimately    limited    compatibility    markers    nervous    lack    sensors    accelerate    relied    versatile    realize    technologies    neurovus    off    cell    biological    organ    biochemical    insights    recapitulate    ions    innovative    interdisciplinary    experts    background    endothelial    integration    oste    trans    structures    drugs    electrical    agents    poor    co    models    collaborations    relevance    time    significantly    date    limitations    acts    metabolites    century    sensor    grand    ensemble    cellular    environment    vivo    disorders    first    health    primary    suited   

Project "NeuroVU" data sheet

The following table provides information about the project.


Organization address
postcode: 100 44

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-27   to  2020-06-26


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Disorders of the central nervous system are one of the grand health challenges of this century. Therapeutic development, however, remains limited by poor understanding of the brain, including of the neurovascular unit (NVU). The NVU acts as the gatekeeper between blood and brain for metabolites, disease agents, as well as drugs. Much research has relied on animals or simple cell models that recapitulate neither the cellular ensemble nor the environment of the NVU. Emerging Organ-on-Chip microsystems promise to overcome these limitations, but to date fall short on the relevance of cells used and the lack of continuous monitoring capabilities for chemical markers, metabolic conversions, and pharmacodynamics.

My objective in this project is to develop the first NVU Organ-on-Chip integrating human-normal cells as well as biophysical and biochemical sensors for real-time monitoring, termed NeuroVU. I propose to rely on primary and induced pluripotent stem cells, which can achieve in-vivo-like properties, and off-stoichiometry thiol-ene-epoxies (OSTE) as the enabling technologies. OSTE is a versatile polymer uniquely suited to supersede the prevalent polydimethylsiloxane/glass paradigm for the innovative system integration approaches needed here. I will first characterize and optimize it for compatibility with biological and sensor components. I will build on these component insights with microsystems integration to develop NeuroVUs featuring co-culture of NVU-normal cells, continuous monitoring of relevant ions & metabolites in addition to trans-endothelial electrical resistance, and tissue-like hydrogel structures. I will leverage collaborations with resident experts in materials and biology as well as my own strong background in microsystems integration to realize this highly interdisciplinary project. Ultimately, the NeuroVU will allow for unprecedented insights on NVU chemistry and has the potential to significantly accelerate pharmaceutical development.


year authors and title journal last update
List of publications.
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Back cover
published pages: 1310-1310, ISSN: 1473-0197, DOI: 10.1039/d0lc90035d
Lab on a Chip 20/7 2020-04-15
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling
published pages: 1212-1226, ISSN: 1473-0197, DOI: 10.1039/d0lc00009d
Lab on a Chip 20/7 2020-04-15
2019 Erica Zeglio, Alexandra L. Rutz, Thomas E. Winkler, George G. Malliaras, Anna Herland
Conjugated Polymers for Assessing and Controlling Biological Functions
published pages: 1806712, ISSN: 0935-9648, DOI: 10.1002/adma.201806712
Advanced Materials 2019-04-16

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