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NeuroVU SIGNED

NeuroVU: Real-time Sensing in Microfluidic Models of the Neurovascular Unit

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuroVU project word cloud

Explore the words cloud of the NeuroVU project. It provides you a very rough idea of what is the project "NeuroVU" about.

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Project "NeuroVU" data sheet

The following table provides information about the project.

Coordinator
KUNGLIGA TEKNISKA HOEGSKOLAN 

Organization address
address: BRINELLVAGEN 8
city: STOCKHOLM
postcode: 100 44
website: www.kth.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-27   to  2020-06-26

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) coordinator 185˙857.00

Map

 Project objective

Disorders of the central nervous system are one of the grand health challenges of this century. Therapeutic development, however, remains limited by poor understanding of the brain, including of the neurovascular unit (NVU). The NVU acts as the gatekeeper between blood and brain for metabolites, disease agents, as well as drugs. Much research has relied on animals or simple cell models that recapitulate neither the cellular ensemble nor the environment of the NVU. Emerging Organ-on-Chip microsystems promise to overcome these limitations, but to date fall short on the relevance of cells used and the lack of continuous monitoring capabilities for chemical markers, metabolic conversions, and pharmacodynamics.

My objective in this project is to develop the first NVU Organ-on-Chip integrating human-normal cells as well as biophysical and biochemical sensors for real-time monitoring, termed NeuroVU. I propose to rely on primary and induced pluripotent stem cells, which can achieve in-vivo-like properties, and off-stoichiometry thiol-ene-epoxies (OSTE) as the enabling technologies. OSTE is a versatile polymer uniquely suited to supersede the prevalent polydimethylsiloxane/glass paradigm for the innovative system integration approaches needed here. I will first characterize and optimize it for compatibility with biological and sensor components. I will build on these component insights with microsystems integration to develop NeuroVUs featuring co-culture of NVU-normal cells, continuous monitoring of relevant ions & metabolites in addition to trans-endothelial electrical resistance, and tissue-like hydrogel structures. I will leverage collaborations with resident experts in materials and biology as well as my own strong background in microsystems integration to realize this highly interdisciplinary project. Ultimately, the NeuroVU will allow for unprecedented insights on NVU chemistry and has the potential to significantly accelerate pharmaceutical development.

 Publications

year authors and title journal last update
List of publications.
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Back cover
published pages: 1310-1310, ISSN: 1473-0197, DOI: 10.1039/d0lc90035d
Lab on a Chip 20/7 2020-04-15
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling
published pages: 1212-1226, ISSN: 1473-0197, DOI: 10.1039/d0lc00009d
Lab on a Chip 20/7 2020-04-15
2019 Erica Zeglio, Alexandra L. Rutz, Thomas E. Winkler, George G. Malliaras, Anna Herland
Conjugated Polymers for Assessing and Controlling Biological Functions
published pages: 1806712, ISSN: 0935-9648, DOI: 10.1002/adma.201806712
Advanced Materials 2019-04-16

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The information about "NEUROVU" are provided by the European Opendata Portal: CORDIS opendata.

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