Opendata, web and dolomites


NeuroVU: Real-time Sensing in Microfluidic Models of the Neurovascular Unit

Total Cost €


EC-Contrib. €






 NeuroVU project word cloud

Explore the words cloud of the NeuroVU project. It provides you a very rough idea of what is the project "NeuroVU" about.

neurovu    electrical    termed    microsystems    models    stoichiometry    date    epoxies    therapeutic    hydrogel    biochemical    limited    oste    suited    featuring    prevalent    cells    glass    metabolites    chemical    co    conversions    disease    vivo    agents    neurovascular    first    environment    off    chip    ions    unprecedented    integrating    promise    lack    century    accelerate    realize    drugs    supersede    continuous    human    grand    structures    chemistry    ensemble    time    biological    acts    central    pharmaceutical    sensors    collaborations    thiol    endothelial    background    compatibility    ene    integration    stem    recapitulate    primary    normal    brain    poor    resistance    resident    sensor    pluripotent    cell    innovative    overcome    uniquely    metabolic    relied    versatile    biology    optimize    materials    relevance    fall    limitations    pharmacodynamics    rely    organ    leverage    paradigm    polydimethylsiloxane    disorders    insights    significantly    monitoring    components    neurovus    nor    experts    tissue    culture    cellular    nervous    markers    nvu    animals    ultimately    health    interdisciplinary    technologies    polymer    gatekeeper    blood    trans    biophysical   

Project "NeuroVU" data sheet

The following table provides information about the project.


Organization address
postcode: 100 44

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-27   to  2020-06-26


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Disorders of the central nervous system are one of the grand health challenges of this century. Therapeutic development, however, remains limited by poor understanding of the brain, including of the neurovascular unit (NVU). The NVU acts as the gatekeeper between blood and brain for metabolites, disease agents, as well as drugs. Much research has relied on animals or simple cell models that recapitulate neither the cellular ensemble nor the environment of the NVU. Emerging Organ-on-Chip microsystems promise to overcome these limitations, but to date fall short on the relevance of cells used and the lack of continuous monitoring capabilities for chemical markers, metabolic conversions, and pharmacodynamics.

My objective in this project is to develop the first NVU Organ-on-Chip integrating human-normal cells as well as biophysical and biochemical sensors for real-time monitoring, termed NeuroVU. I propose to rely on primary and induced pluripotent stem cells, which can achieve in-vivo-like properties, and off-stoichiometry thiol-ene-epoxies (OSTE) as the enabling technologies. OSTE is a versatile polymer uniquely suited to supersede the prevalent polydimethylsiloxane/glass paradigm for the innovative system integration approaches needed here. I will first characterize and optimize it for compatibility with biological and sensor components. I will build on these component insights with microsystems integration to develop NeuroVUs featuring co-culture of NVU-normal cells, continuous monitoring of relevant ions & metabolites in addition to trans-endothelial electrical resistance, and tissue-like hydrogel structures. I will leverage collaborations with resident experts in materials and biology as well as my own strong background in microsystems integration to realize this highly interdisciplinary project. Ultimately, the NeuroVU will allow for unprecedented insights on NVU chemistry and has the potential to significantly accelerate pharmaceutical development.


year authors and title journal last update
List of publications.
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Back cover
published pages: 1310-1310, ISSN: 1473-0197, DOI: 10.1039/d0lc90035d
Lab on a Chip 20/7 2020-04-15
2020 Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna Herland
Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling
published pages: 1212-1226, ISSN: 1473-0197, DOI: 10.1039/d0lc00009d
Lab on a Chip 20/7 2020-04-15
2019 Erica Zeglio, Alexandra L. Rutz, Thomas E. Winkler, George G. Malliaras, Anna Herland
Conjugated Polymers for Assessing and Controlling Biological Functions
published pages: 1806712, ISSN: 0935-9648, DOI: 10.1002/adma.201806712
Advanced Materials 2019-04-16

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