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GammaDelta SIGNED

DECIPHERING THE MEMORY OF gd T CELLS: DOES IT HAVE A ROLE IN CROSS-PROTECTION OF BACILLE CALMETTE-GUERIN VACCINATION?

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GammaDelta" data sheet

The following table provides information about the project.

Coordinator
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN 

Organization address
address: REGINA PACIS WEG 3
city: BONN
postcode: 53113
website: www.uni-bonn.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-03   to  2020-05-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN DE (BONN) coordinator 159˙460.00

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 Project objective

Infectious diseases are one of main global health threats in the 21st century, with antibiotic resistance and specific threats such as Human Immunodeficiency Virus (HIV) and tuberculosis (TB) being of biggest concern to Europe. Vaccination is the most efficient approach to prevent infections. The efficiency of vaccines relies on the memory of the immune system. For decades the ability of an immune cell to “remember” a primary infection and subsequently to respond more effectively to the reinfection was solely attributed to adaptive immune cells. Recent findings showed that innate cells can also develop immune memory. In contrast to adaptive immune cells, the secondary response of innate cells is not pathogen-specific. In both cases the development of memory phenotype is accompanied by epigenetic changes in chromatin structure. These findings raise important questions: what decides about the ability of innate immune cells to mount memory phenotype and which factors trigger the secondary response? Does it lie in the type of receptors involved in the pathogen recognition or in chromatin modifications? “GammaDelta” project aims to answer these questions by studying gamma delta (gd) T cells which share characteristics of both innate and adaptive immune cells. Bacille Calmette-Guerin (BCG) vaccine developed to protect against TB induces memory gd T cells and it has been also shown to have a cross-protective effect. The role of memory gd T cells in this process has not been addressed. By applying traditional immunology techniques and newest high throughput sequencing based methodology I will examine the potential of BCG-induced memory gd T cells for the protective effects of the vaccine and which epigenetic mechanisms underlie this process. This will help to understand the interaction between immunological pathways and epigenetic modifications in innate immune memory, a knowledge necessary for the design of a new generation of more effective vaccines.

 Publications

year authors and title journal last update
List of publications.
2019 Katarzyna Placek, Joachim L. Schultze, Mihai G. Netea
Immune memory characteristics of innate lymphoid cells
published pages: 196-203, ISSN: 0951-7375, DOI: 10.1097/qco.0000000000000540
Current Opinion in Infectious Diseases 32/3 2019-09-09
2019 Mihai G. Netea, Andreas Schlitzer, Katarzyna Placek, Leo A.B. Joosten, Joachim L. Schultze
Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
published pages: 13-26, ISSN: 1931-3128, DOI: 10.1016/j.chom.2018.12.006
Cell Host & Microbe 25/1 2019-09-09

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The information about "GAMMADELTA" are provided by the European Opendata Portal: CORDIS opendata.

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