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GammaDelta SIGNED

DECIPHERING THE MEMORY OF gd T CELLS: DOES IT HAVE A ROLE IN CROSS-PROTECTION OF BACILLE CALMETTE-GUERIN VACCINATION?

Total Cost €

EC-Contrib. €

Partnership

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GammaDelta project word cloud

Explore the words cloud of the GammaDelta project. It provides you a very rough idea of what is the project "GammaDelta" about.

health understand epigenetic shown bacille effect attributed secondary protect resistance throughput century gammadelta lie mechanisms sequencing answer cells relies diseases prevent cross pathogen showed underlie immunological immunodeficiency infection interaction trigger threats hiv examine solely chromatin vaccine share gd decades vaccines delta tuberculosis guerin infections receptors immunology remember cell virus reinfection induces generation tb memory global 21st techniques modifications gamma infectious subsequently response adaptive methodology antibiotic decides phenotype recognition structure mount calmette immune primary questions accompanied bcg innate biggest vaccination human protective efficient newest efficiency contrast

Project "GammaDelta" data sheet

The following table provides information about the project.

Coordinator	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 website: www.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	159˙460 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-05-03 to 2020-05-02

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 website: www.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	coordinator	159˙460.00

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Project objective

Infectious diseases are one of main global health threats in the 21st century, with antibiotic resistance and specific threats such as Human Immunodeficiency Virus (HIV) and tuberculosis (TB) being of biggest concern to Europe. Vaccination is the most efficient approach to prevent infections. The efficiency of vaccines relies on the memory of the immune system. For decades the ability of an immune cell to “remember” a primary infection and subsequently to respond more effectively to the reinfection was solely attributed to adaptive immune cells. Recent findings showed that innate cells can also develop immune memory. In contrast to adaptive immune cells, the secondary response of innate cells is not pathogen-specific. In both cases the development of memory phenotype is accompanied by epigenetic changes in chromatin structure. These findings raise important questions: what decides about the ability of innate immune cells to mount memory phenotype and which factors trigger the secondary response? Does it lie in the type of receptors involved in the pathogen recognition or in chromatin modifications? “GammaDelta” project aims to answer these questions by studying gamma delta (gd) T cells which share characteristics of both innate and adaptive immune cells. Bacille Calmette-Guerin (BCG) vaccine developed to protect against TB induces memory gd T cells and it has been also shown to have a cross-protective effect. The role of memory gd T cells in this process has not been addressed. By applying traditional immunology techniques and newest high throughput sequencing based methodology I will examine the potential of BCG-induced memory gd T cells for the protective effects of the vaccine and which epigenetic mechanisms underlie this process. This will help to understand the interaction between immunological pathways and epigenetic modifications in innate immune memory, a knowledge necessary for the design of a new generation of more effective vaccines.

Publications

List of publications.
year	authors and title	journal	last update
2019	Katarzyna Placek, Joachim L. Schultze, Mihai G. Netea Immune memory characteristics of innate lymphoid cells published pages: 196-203, ISSN: 0951-7375, DOI: 10.1097/qco.0000000000000540	Current Opinion in Infectious Diseases 32/3	2019-09-09
2019	Mihai G. Netea, Andreas Schlitzer, Katarzyna Placek, Leo A.B. Joosten, Joachim L. Schultze Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Hostâ€™s Response to Pathogens published pages: 13-26, ISSN: 1931-3128, DOI: 10.1016/j.chom.2018.12.006	Cell Host & Microbe 25/1	2019-09-09

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