Opendata, web and dolomites

NANOBOTS SIGNED

Tumor-Targeting Nanoengineered Bioorthogonal Technologies to Fight Metastatic Cancers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NANOBOTS project word cloud

Explore the words cloud of the NANOBOTS project. It provides you a very rough idea of what is the project "NANOBOTS" about.

prodrug    abiotic    click    strategy    treatment    expressed    deprotection    administered    pioneers    tetrazine    organometallic    navigational    metastatic    proteins    release    chemistry    activate    biology    cell    independence    emerged    powerful    identification    perform    cytotoxic    multidisciplinary    designs    therapy    pd    professional    translation    multifunctional    time    precursors    drug    edinburgh    mentorship    lab    bioorthogonal    dr    primary    techniques    cancer    world    supramolecular    modular    nanotechnology    disease    cancers    solid    msca    nanomachine    unprecedented    broceta    machineries    catalyzed    opportunity    unciti    inside    performing    designed    configured    living    ground    overexpressed    guide    classes    cells    innovative    installed    tumours    protein    uk    nanobots    functionalized    activation    medicinal    centre    termed    treat    first    tag    limited    systemically    nanodevices    lesions    class    breadth    track    surface   

Project "NANOBOTS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-19   to  2020-11-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of the pioneers of the Bioorthogonal Organometallic Chemistry field. This will certainly promote the translation of the results and enhance my professional growth towards my research independence.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOBOTS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANOBOTS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

eXcape3D (2019)

Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation

Read More  

VINCI (2020)

The Value of Information and Choice to Improve Control.

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More