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NANOBOTS SIGNED

Tumor-Targeting Nanoengineered Bioorthogonal Technologies to Fight Metastatic Cancers

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOBOTS project word cloud

Explore the words cloud of the NANOBOTS project. It provides you a very rough idea of what is the project "NANOBOTS" about.

time    unciti    cells    unprecedented    treatment    release    performing    pd    treat    track    pioneers    inside    overexpressed    nanobots    drug    installed    classes    primary    first    catalyzed    cancer    lesions    cytotoxic    multidisciplinary    machineries    activation    ground    guide    multifunctional    disease    click    translation    nanodevices    bioorthogonal    emerged    supramolecular    metastatic    organometallic    centre    lab    termed    proteins    medicinal    class    chemistry    abiotic    solid    nanomachine    mentorship    msca    surface    tetrazine    administered    designed    configured    nanotechnology    designs    innovative    world    identification    protein    powerful    functionalized    navigational    living    perform    modular    therapy    prodrug    uk    systemically    breadth    independence    broceta    cell    tag    edinburgh    biology    tumours    strategy    dr    precursors    limited    cancers    deprotection    techniques    professional    activate    opportunity    expressed   

Project "NANOBOTS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-19   to  2020-11-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of the pioneers of the Bioorthogonal Organometallic Chemistry field. This will certainly promote the translation of the results and enhance my professional growth towards my research independence.

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The information about "NANOBOTS" are provided by the European Opendata Portal: CORDIS opendata.

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