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NANOBOTS SIGNED

Tumor-Targeting Nanoengineered Bioorthogonal Technologies to Fight Metastatic Cancers

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOBOTS project word cloud

Explore the words cloud of the NANOBOTS project. It provides you a very rough idea of what is the project "NANOBOTS" about.

proteins    pioneers    protein    cytotoxic    strategy    administered    systemically    centre    opportunity    tumours    treatment    independence    prodrug    cancers    termed    tag    msca    drug    release    therapy    nanobots    overexpressed    professional    techniques    lab    breadth    organometallic    click    unprecedented    powerful    nanomachine    cancer    time    activate    ground    guide    surface    pd    metastatic    deprotection    uk    abiotic    modular    class    dr    precursors    designs    installed    emerged    primary    activation    functionalized    medicinal    cell    expressed    machineries    track    inside    edinburgh    lesions    living    nanodevices    biology    identification    world    catalyzed    multifunctional    configured    supramolecular    perform    treat    tetrazine    disease    nanotechnology    performing    chemistry    solid    first    bioorthogonal    translation    multidisciplinary    broceta    cells    unciti    limited    designed    classes    navigational    mentorship    innovative   

Project "NANOBOTS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-19   to  2020-11-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of the pioneers of the Bioorthogonal Organometallic Chemistry field. This will certainly promote the translation of the results and enhance my professional growth towards my research independence.

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The information about "NANOBOTS" are provided by the European Opendata Portal: CORDIS opendata.

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