Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. eyetreat

EyeTREAT SIGNED

Innovative tool for personalized treatment of patients with neovascular age-macular degeneration: dosage optimization for long term efficacy treatment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 EyeTREAT project word cloud

Explore the words cloud of the EyeTREAT project. It provides you a very rough idea of what is the project "EyeTREAT" about.

anticipated    renowned    effect    avastin    care    disciplinary    illnesses    injections    ageing    measuring    burden    oct    definitely    frequency    age    dose    coherence    university    patients    lasting    intravitreal    million    tools    inter    individualized    vegf    regular    pharmacodynamic    vitreous    2040    central    clinical    visual    therapeutic    clinics    models    character    invasively    pharmacokinetic    sectoral    25    anti    eye    combining    linking    constitute    missing    instance    almost    patient    intervals    threatening    retina    benefit    ball    pioneer    with    first    varies    consensus    optical    computational    career    eylea    reducing    population    individual    determinations    treatment    scan    dosing    health    optimization    clear    amd    quality    expertise    macular    candidate    manchester    thickness    appropriate    regimen    imaging    rest    degeneration    europeans    researcher    technique    treatments    drug    efficient    tomography    ocular    ophthalmic    injection    tool    consists    quantitative    centre    personalization    lucentis    life   

Project "EyeTREAT" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.research.manchester.ac.uk/portal/evamaria.delamo.html
 Total cost 122˙159 €
 EC max contribution 122˙159 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 122˙159.00

Map

 Project objective

With the ageing population, visual threatening illnesses are increasing. For instance, age-related macular degeneration (AMD) is expected to affect almost 25 million Europeans by 2040. The AMD treatment consists in regular injections of the anti-VEGF therapeutic drug (Lucentis, Avastin, Eylea) into the eye ball, vitreous, for the rest of the patient life. However, the dosing intervals varies widely among the patients and there is no a clear consensus or quantitative method for evaluating the injection frequency. For that, computational tools linking the drug dose regimen and the drug effect in the retina are needed. However, such pharmacokinetic-pharmacodynamic models are still missing. Combining population pharmacokinetic and optical coherence tomography (OCT) imaging technique is a new, novel and promising approach. The drug effect can be evaluated non-invasively, measuring the central macular thickness in the retina scan. The models generated will allow appropriate individualized dosing regimen to the patients in clinics that will be anticipated from individual retina scan determinations with OCT. The optimization and personalization of dosing regimen will ensure an efficient long-lasting treatment, improving patient quality of life while reducing the burden to the health care system. Moreover, the models will increase our understanding in the treatments, constitute a pioneer tool in effect assessment in ocular therapeutic field and a first step towards more advanced ophthalmic models. The candidate has strong expertise in intravitreal pharmacokinetic and this project will advance her into clinical pharmacodynamic modelling at the renowned Centre for Applied Pharmacokinetic Research, University of Manchester. The inter-disciplinary and inter-sectoral character of the project will definitely benefit her career development as a researcher.

 Publications

year authors and title journal last update
List of publications.
2019 Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ruponen, Arto Urtti
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
published pages: 1446-1457, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2019.02.001 		Drug Discovery Today 24/8 2020-04-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EYETREAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EYETREAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

DNANanoProbes (2019)

Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.

Read More  

PmNC (2019)

Policy-making of early nature conservation. The Netherlands and the United Kingdom compared, 1930-1960

Read More  

InBPSOC (2020)

Increases biomass production and soil organic carbon stocks with innovative cropping systems under climate change

Read More