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TRANSREG SIGNED

Dissecting the role of Translational Regulation in Tumorigenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TRANSREG project word cloud

Explore the words cloud of the TRANSREG project. It provides you a very rough idea of what is the project "TRANSREG" about.

systematically    malignancy    downstream    cas9    frontier    function    synthesis    uorf    transformation    surprisingly    malignant    suggest    monitor    switch    elucidate    surfacing    fundamentally    crispr    oncogenic    revealed    fate    thousands    upstream    strategies    tumor    select    conduct    unravel    unearthed    generate    cancer    cellular    impose    unappreciated    translation    relevance    observations    eif2a    regulation    expose    screen    human    mediated    homeostasis    transition    tumorigenesis    correlations    reading    constitute    regulators    force    aberrant    detect    vivo    gene    defines    expression    databases    programs    paradigms    eif2    collectively    conventional    driving    differentiation    levels    networks    gain    tools    progression    treatment    hitherto    determinant    turn    mrna    altered    drivers    mechanistic    unveiled    analyze    translational    document    stages    raises    uorfs    possibility    mice    intriguing    initiation    first    unprecedented    protein    abundance    frame    alternative    diagnostics   

Project "TRANSREG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙977˙148 €
 EC max contribution 1˙977˙148 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 1˙977˙148.00
2    UNIVERSITE DE LAUSANNE CH (LAUSANNE) participant 0.00

Map

 Project objective

The control of translation is a key determinant of protein abundance, which in turn defines cellular states. The impact of translational regulation may be even greater during the transition from homeostasis to malignancy, as revealed by the surprisingly low correlations between mRNA and protein levels in human cancer databases. This raises the intriguing possibility that through an ability to generate aberrant downstream networks of translational regulators, oncogenic drivers might impose altered protein synthesis programs that become the driving force for tumor formation and malignant progression. We recently unveiled a hitherto unappreciated role for upstream open reading frame (uORF) translation in tumorigenesis and unearthed a novel switch from conventional EIF2 initiation factor-mediated to alternative EIF2A-mediated uORF translation. These observations suggest that uORFs constitute an exciting new frontier in the field of translational regulation with the potential to fundamentally impact cellular fate. Here, I propose to systematically analyze the function of uORFs during tumorigenesis. First, we will conduct an in vivo CRISPR/CAS9-based screen in mice to elucidate the role of thousands of uORFs in development, differentiation and upon oncogenic transformation. Second, focusing on select uORFs surfacing in the screen, we will document their role during tumor initiation and progression. Third, we will develop novel tools to detect uORF translation in vivo, exploit them to monitor uORF translation during different stages of tumorigenesis, gain mechanistic insight into their function and finally test the relevance of these findings in human cancer. Collectively, these approaches will provide unprecedented and comprehensive insight into the function of uORFs, unravel new paradigms in the control of gene expression and expose novel strategies for cancer diagnostics and treatment.

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The information about "TRANSREG" are provided by the European Opendata Portal: CORDIS opendata.

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