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ElectroGene SIGNED

Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

Total Cost €

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EC-Contrib. €

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Partnership

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 ElectroGene project word cloud

Explore the words cloud of the ElectroGene project. It provides you a very rough idea of what is the project "ElectroGene" about.

time    chemical    volatile    diagnostics    physical    direct    dosing    human    expression    pillars    wireless    insulated    wave    contrast    diagnosis    programmed    communication    gigahertz    made    complexity    networks    genetically    triggered    implants    analog    man    mind    closed    electrogene    things    remote    interfaces    central    simultaneously    principles    electro    genetic    limited    smartphone    signals    cells    flow    contact    capitalizing    loop    molecular    designer    metal    wearable    largely    therapy    electronics    frequency    electronic    membranes    medical    share    treatment    glucose    powered    google    units    adjustable    block    therapeutics    electrons    protein    disease    electrogenetics    lenses    onset    soluble    full    reactions    monitoring    preclinical    ecosystem    living    bioelectronics    bioelectronic    proof    harnessing    gene    metabolic    vision    slow    prevention    wired    linking    diabetes    profile    internet    radically    multicore    ion    multicellular    wires    interconnected    consists    gradients    heartbeat    biological    drug    validated    incompatible    optogenetic    metabolism    science    voltage    connections    advent    implanted    uses    differently    communicate    foundations   

Project "ElectroGene" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙500˙000.00

Map

 Project objective

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, thus linking diagnosis and therapy to block disease onset (prevention). ElectroGene design principles and devices will be validated in proof-of-concept preclinical studies for the treatment of diabetes.

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The information about "ELECTROGENE" are provided by the European Opendata Portal: CORDIS opendata.

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