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ElectroGene SIGNED

Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

Total Cost €

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EC-Contrib. €

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Partnership

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 ElectroGene project word cloud

Explore the words cloud of the ElectroGene project. It provides you a very rough idea of what is the project "ElectroGene" about.

closed    implants    block    triggered    living    metal    profile    interconnected    uses    ecosystem    made    contrast    multicore    bioelectronics    preclinical    advent    limited    wearable    smartphone    electrogenetics    foundations    reactions    differently    man    mind    human    ion    glucose    lenses    interfaces    electronics    flow    chemical    optogenetic    diagnosis    volatile    treatment    protein    therapeutics    multicellular    radically    contact    expression    largely    onset    wires    bioelectronic    units    gigahertz    cells    vision    signals    wireless    pillars    loop    google    heartbeat    consists    direct    drug    voltage    validated    incompatible    proof    diagnostics    designer    electro    principles    central    wired    time    insulated    slow    frequency    adjustable    biological    powered    metabolic    capitalizing    electrons    gradients    molecular    communicate    monitoring    physical    complexity    prevention    dosing    genetic    medical    electronic    electrogene    full    simultaneously    diabetes    membranes    gene    linking    harnessing    metabolism    genetically    share    therapy    science    communication    programmed    connections    internet    wave    implanted    networks    remote    things    analog    soluble    disease   

Project "ElectroGene" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙500˙000.00

Map

 Project objective

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, thus linking diagnosis and therapy to block disease onset (prevention). ElectroGene design principles and devices will be validated in proof-of-concept preclinical studies for the treatment of diabetes.

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The information about "ELECTROGENE" are provided by the European Opendata Portal: CORDIS opendata.

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