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ElectroGene SIGNED

Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

Total Cost €

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EC-Contrib. €

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Partnership

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 ElectroGene project word cloud

Explore the words cloud of the ElectroGene project. It provides you a very rough idea of what is the project "ElectroGene" about.

pillars    gene    heartbeat    therapy    uses    adjustable    science    insulated    implants    capitalizing    volatile    reactions    complexity    ion    time    share    made    voltage    units    gigahertz    multicore    principles    signals    membranes    metal    communicate    internet    wearable    central    connections    wired    genetically    foundations    mind    expression    cells    networks    block    designer    disease    physical    biological    triggered    closed    electrogenetics    human    wave    chemical    direct    bioelectronics    medical    communication    prevention    differently    implanted    electrons    metabolism    ecosystem    gradients    multicellular    diagnosis    metabolic    largely    linking    electrogene    interconnected    wires    contact    monitoring    electro    molecular    therapeutics    interfaces    glucose    remote    analog    slow    proof    diagnostics    profile    frequency    radically    optogenetic    preclinical    vision    electronic    full    treatment    protein    bioelectronic    soluble    incompatible    onset    flow    contrast    genetic    things    lenses    limited    validated    dosing    loop    man    google    powered    electronics    smartphone    consists    advent    wireless    simultaneously    harnessing    drug    programmed    diabetes    living   

Project "ElectroGene" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙500˙000.00

Map

 Project objective

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, thus linking diagnosis and therapy to block disease onset (prevention). ElectroGene design principles and devices will be validated in proof-of-concept preclinical studies for the treatment of diabetes.

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The information about "ELECTROGENE" are provided by the European Opendata Portal: CORDIS opendata.

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