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ElectroGene SIGNED

Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

Total Cost €

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EC-Contrib. €

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Partnership

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 ElectroGene project word cloud

Explore the words cloud of the ElectroGene project. It provides you a very rough idea of what is the project "ElectroGene" about.

electrogene    treatment    proof    diagnosis    units    adjustable    membranes    things    electrons    signals    frequency    optogenetic    dosing    multicellular    block    pillars    electro    wires    human    implants    share    designer    central    metabolism    preclinical    programmed    triggered    foundations    communication    harnessing    gigahertz    wave    slow    electronics    electrogenetics    full    lenses    simultaneously    closed    analog    google    gene    metal    insulated    validated    therapeutics    uses    radically    disease    time    biological    contact    voltage    wired    networks    science    onset    vision    mind    largely    monitoring    direct    reactions    cells    diagnostics    bioelectronic    differently    made    ecosystem    gradients    complexity    internet    flow    interfaces    molecular    communicate    electronic    capitalizing    ion    multicore    connections    loop    expression    prevention    contrast    metabolic    bioelectronics    drug    genetic    limited    therapy    wearable    medical    principles    volatile    physical    powered    interconnected    wireless    remote    linking    chemical    incompatible    glucose    soluble    profile    implanted    living    smartphone    diabetes    advent    man    heartbeat    consists    genetically    protein   

Project "ElectroGene" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙500˙000.00

Map

 Project objective

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, thus linking diagnosis and therapy to block disease onset (prevention). ElectroGene design principles and devices will be validated in proof-of-concept preclinical studies for the treatment of diabetes.

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The information about "ELECTROGENE" are provided by the European Opendata Portal: CORDIS opendata.

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