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RiboTrace SIGNED

Bridging temporal resolution gaps to dissect RNA silencing at the molecular and genomic scale

Total Cost €

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EC-Contrib. €

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Partnership

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 RiboTrace project word cloud

Explore the words cloud of the RiboTrace project. It provides you a very rough idea of what is the project "RiboTrace" about.

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Project "RiboTrace" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙998˙476 €
 EC max contribution 1˙998˙476 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 1˙998˙476.00

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 Project objective

The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has been paid to the regulation of transcription, the control over RNA fate and function has only recently emerged as a central hallmark of gene regulation with enormous biological, technological and biomedical implications. Here, we propose to study the molecular principles of RNA silencing, the least understood aspect of post-transcriptional gene regulation. We aim to systematically dissect the mechanisms and biological functions of RNA 3´end uridylation to determine the emerging role of RNA modifications in the regulation of gene expression; we will elucidate fundamental principles of RNA turnover at the genomic scale by time-resolved transcriptomics; and we will use functional genomics and haploid genetics to systematically delineate post-transcriptional gene regulatory pathways. Throughout, we will link our results back to the established function of RNA silencing in the control of organismal development, physiology and disease. Our goal is to acquire fundamental insights into the processes that survey the quality and quantity of the transcriptome to determine possible molecular causes for aberrant RNA levels that have been associated with diverse human diseases. Because of its genetic and biochemical tools, we will use Drosophila melanogaster as a model organism. We will employ a combination of in vivo genetics, cell-free biochemical experiments, bioinformatics, and cell culture methods. What we learn in flies we will test for its conservation in mammalian cell extracts and cultured cells. Overall, we will determine fundamental biological mechanisms of gene regulation trough pathways with enormous biological impact in health and disease.

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The information about "RIBOTRACE" are provided by the European Opendata Portal: CORDIS opendata.

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