Opendata, web and dolomites

HybReader SIGNED

Mechanisms of epigenetic gene regulation by R-loops

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HybReader project word cloud

Explore the words cloud of the HybReader project. It provides you a very rough idea of what is the project "HybReader" about.

regulation    vitro    mediates    escs    integrity    mammalian    hypothesis    disease    differentiation    prevalent    epigenetic    pluripotency    interface    biology    found    thinking    rnas    stem    notably    gc    eleven    function    tet    obscure    preventing    point    local    demethylation    chromatin    binders    rna    entry    nuclear    vivo    act    decade    regulatory    damage    mechanisms    reader    threat    cells    site    breakthrough    lie    shape    revolutionized    questions    readers    lncrnas    regulators    methylation    genome    additional    loops    protein    time    enriched    hydroxymethylation    discovery    nascent    decoded    beginning    presented    ground    implicated    poorly    translocation    gene    first    promoters    hybreader    oxidases    discoveries    transcription    sequence    tool    systematically    ten    neurodegenerative    fundamental    certain    expression    loop    provides    hybrids    erased    last    binds    esc    remained    retained    breaking    biological    regarding    cytosine    embryonic    genomic    dna    screen    indicates   

Project "HybReader" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH 

Organization address
address: ACKERMANNWEG 4
city: MAINZ
postcode: 55128
website: www.imb-mainz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH DE (MAINZ) coordinator 2˙000˙000.00

Map

 Project objective

The last decade has revolutionized our thinking about regulatory RNAs and yet we are still at the beginning of understanding their biology. One such challenge is presented by R-loops, prevalent DNA:RNA hybrids, which lie at the interface of different nuclear processes, including transcription, RNA processing, lncRNAs, DNA damage, chromatin, and neurodegenerative disease. Long-time considered a threat to genomic integrity, recent evidence indicates that certain R-loops can act as epigenetic gene regulators. The hypothesis is that nascent RNAs retained at their site of transcription may function as sequence-specific component of mammalian chromatin to shape gene expression. Notably, R-loops found at GC-enriched promoters are implicated in preventing DNA methylation and promote transcription, but how this might occur has remained obscure. In a breakthrough discovery, we identified the first epigenetic R-loop reader. This protein binds directly and specifically to DNA:RNA hybrids in vitro and in vivo, and mediates local DNA hydroxymethylation and demethylation via TET (Ten-Eleven Translocation) cytosine oxidases. Using the R-loop reader as a tool provides a unique entry point to address fundamental questions regarding mechanisms and regulation of the epigenetic function and biological role of these DNA:RNA hybrids. Applying genome-wide approaches and studying the biology of embryonic stem cells (ESCs), we will 1) systematically identify regulatory R-loops, 2) characterize their common features, 3) address how R-loops are decoded in ESC pluripotency and differentiation, 4) investigate how regulatory R-loops are erased, and (5) screen for additional R-loop binders/readers and characterize their epigenetic role. The HybReader project will allow for ground-breaking discoveries regarding the emerging epigenetic function and regulation of these poorly understood regulatory hybrids in the control of gene expression.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HYBREADER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HYBREADER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

Cu4Peroxide (2020)

The electrochemical synthesis of hydrogen peroxide

Read More