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HybReader SIGNED

Mechanisms of epigenetic gene regulation by R-loops

Total Cost €

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EC-Contrib. €

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Partnership

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 HybReader project word cloud

Explore the words cloud of the HybReader project. It provides you a very rough idea of what is the project "HybReader" about.

implicated    prevalent    revolutionized    oxidases    gc    embryonic    protein    esc    mediates    thinking    regulatory    loop    act    genome    pluripotency    hypothesis    gene    nascent    mechanisms    retained    shape    hybrids    notably    promoters    remained    binds    rna    neurodegenerative    fundamental    nuclear    decoded    tet    site    questions    lncrnas    rnas    loops    regulation    stem    vivo    biological    regulators    preventing    ground    first    tool    demethylation    found    binders    indicates    interface    sequence    dna    hydroxymethylation    damage    vitro    systematically    additional    epigenetic    lie    provides    biology    readers    cells    integrity    function    point    screen    mammalian    reader    enriched    transcription    hybreader    methylation    erased    breakthrough    presented    obscure    chromatin    time    poorly    genomic    decade    threat    certain    regarding    disease    ten    entry    escs    discovery    discoveries    last    expression    translocation    local    cytosine    eleven    breaking    beginning    differentiation   

Project "HybReader" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH 

Organization address
address: ACKERMANNWEG 4
city: MAINZ
postcode: 55128
website: www.imb-mainz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH DE (MAINZ) coordinator 2˙000˙000.00

Map

 Project objective

The last decade has revolutionized our thinking about regulatory RNAs and yet we are still at the beginning of understanding their biology. One such challenge is presented by R-loops, prevalent DNA:RNA hybrids, which lie at the interface of different nuclear processes, including transcription, RNA processing, lncRNAs, DNA damage, chromatin, and neurodegenerative disease. Long-time considered a threat to genomic integrity, recent evidence indicates that certain R-loops can act as epigenetic gene regulators. The hypothesis is that nascent RNAs retained at their site of transcription may function as sequence-specific component of mammalian chromatin to shape gene expression. Notably, R-loops found at GC-enriched promoters are implicated in preventing DNA methylation and promote transcription, but how this might occur has remained obscure. In a breakthrough discovery, we identified the first epigenetic R-loop reader. This protein binds directly and specifically to DNA:RNA hybrids in vitro and in vivo, and mediates local DNA hydroxymethylation and demethylation via TET (Ten-Eleven Translocation) cytosine oxidases. Using the R-loop reader as a tool provides a unique entry point to address fundamental questions regarding mechanisms and regulation of the epigenetic function and biological role of these DNA:RNA hybrids. Applying genome-wide approaches and studying the biology of embryonic stem cells (ESCs), we will 1) systematically identify regulatory R-loops, 2) characterize their common features, 3) address how R-loops are decoded in ESC pluripotency and differentiation, 4) investigate how regulatory R-loops are erased, and (5) screen for additional R-loop binders/readers and characterize their epigenetic role. The HybReader project will allow for ground-breaking discoveries regarding the emerging epigenetic function and regulation of these poorly understood regulatory hybrids in the control of gene expression.

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The information about "HYBREADER" are provided by the European Opendata Portal: CORDIS opendata.

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