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Can human embryo-released extracellular vesicles govern endometrial receptivity and inform on vanguard embryo diagnostics and fertility therapeutics?

Total Cost €


EC-Contrib. €






 CERVINO project word cloud

Explore the words cloud of the CERVINO project. It provides you a very rough idea of what is the project "CERVINO" about.

methodology    sequencing    internalisation    select    characterise    time    potentiates    harmful    embryos    mechanistic    pilot    effect    uterine    genome    consequently    instead    introduce    additionally    internalised    release    functional    community    showed    vesicles    invasive    exported    controversial    whereby    collectively    material    had    single    transcriptomic    mount    endometrial    consequence    acquisition    screening    pathophysiology    natural    therapeutics    biopsy    human    extracellular    first    embryo    compromise    cell    genes    therapeutic    revealed    group    throughput    scrutinise    profile    cutting    transcriptome    demonstrated    edge    fertilisation    biomarkers    establishment    abundance    ivf    vitro    gene    poor    inspire    pgs    function    receptivity    implantation    rnaseq    transfer    reported    utilising    evs    potentially    preimplantation    cells    biosafety    tackle    primary    genetic    screen    euploid    ecs    biopsies    cargo    upregulation    utilised    innovators    aneuploid    negate    host    paramount    ev    quality    delineating    prior   

Project "CERVINO" data sheet

The following table provides information about the project.


Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-07-02   to  2020-07-01


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 180˙277.00


 Project objective

Preimplantation Genetic Screening (PGS) based on high-throughput embryo genome sequencing is currently utilised in In Vitro Fertilisation (IVF) to select for euploid embryos prior to uterine transfer in order to increase implantation potential. The methodology for the acquisition of genetic material is controversial, as the invasive embryo biopsy required for PGS may compromise embryo quality. Moreover its long-term biosafety has not been evaluated. Consequently, the development of non-invasive methods to screen out aneuploid embryos is paramount. The host research group recently first reported that human IVF embryos release extracellular vesicles (EVs) and demonstrated their uptake by primary endometrial cells (ECs). Our pilot analysis of the embryo-derived EV transcriptome revealed an abundance of genes that may be involved in the establishment of endometrial receptivity. Additionally, our RNAseq on ECs, which had internalised human embryo-exported EVs, showed a gene-upregulation profile relevant to implantation. Collectively, our findings introduce a novel concept to the state-of-the-art whereby human embryos deliver a functional EV-transcriptomic cargo to ECs to mount an implantation response. Delineating the EV transcriptome, and studying the consequence of its delivery in ECs, potentiates mechanistic insight into the pathophysiology of implantation. The project will characterise for the first time the transcriptomic cargo of euploid and aneuploid human embryo-exported EVs and scrutinise the effect of its internalisation on endometrial function. This cutting-edge work may negate potentially harmful invasive embryo biopsies for PGS by instead utilising biomarkers in EVs – a ‘natural cell biopsy’. EV biomarkers could also inspire therapeutics to enhance endometrial receptivity. This programme is especially timely, as leading innovators in the field currently focus to provide the community with a single therapeutic approach to tackle poor endometrial function.


year authors and title journal last update
List of publications.
2018 Sofia Makieva, Elisa Giacomini, Jessica Ottolina, Ana Sanchez, Enrico Papaleo, Paola Viganò
Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
published pages: 2477, ISSN: 1422-0067, DOI: 10.3390/ijms19092477
International Journal of Molecular Sciences 19/9 2019-06-11

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The information about "CERVINO" are provided by the European Opendata Portal: CORDIS opendata.

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