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VES4US SIGNED

Extracellular vesicles from a natural source for tailor-made nanomaterials

Total Cost €

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EC-Contrib. €

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Partnership

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 VES4US project word cloud

Explore the words cloud of the VES4US project. It provides you a very rough idea of what is the project "VES4US" about.

isolation    therapy    biomolecules    source    proteins    prominent    tissues    native    brain    internalised    progresses    expanding    made    translation    natural    radically    vehicle    life    species    platform    intercellular    biocarriers    influence    ves4us    cosmetics    interests    skin    core    body    intrinsically    functionalisation    biomedical    drug    extracellular    lung    evs    nanovesicles    barrier    nanocarriers    circulating    constitute    vesicles    membranous    communication    discovery    stakeholders    inter    tailor    profit    innovation    tolerated    union    nutraceutics    loaded    transferring    free    sustainable    half    unprecedented    landscape    particles    efficient    despite    hampered    translational    endorsed    actively    economically    cell    clinical    market    industrial    dendritic    tumor    nanomedicine    crossing    significantly    possess    blood    characterisation    oriented    raised    rnas    created    attributes    lack    mammalian    outside    cells    mediate    recipient    suitable    ev   

Project "VES4US" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://ves4us.eu/
 Total cost 2˙946˙303 €
 EC max contribution 2˙946˙303 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 1˙166˙412.00
2    INSTITUTE OF TECHNOLOGY SLIGO - ITS IE (SLIGO) participant 560˙187.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 499˙998.00
4    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 303˙455.00
5    ZABALA INNOVATION CONSULTING, S.A. ES (MUTILVA ALTA NAVARRA) participant 222˙500.00
6    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 193˙750.00

Map

 Project objective

Extracellular vesicles (EVs) are cell-derived, membranous particles that mediate intercellular communication by transferring biomolecules such as proteins and RNAs. The discovery of EVs as natural biocarriers and inter-species communication means has raised great interest in the drug delivery field. EVs intrinsically possess many attributes of a drug delivery vehicle, since these particles i) are well tolerated in the body, ii) have long circulating half-life, iii) are internalised by recipient cells and iv) are able of crossing the blood brain barrier. Native and drug-loaded mammalian cell-derived EVs have recently been developed and are contributing to the expanding research field known as “cell-free therapy”. Despite these promising progresses, translational applications are currently hampered by the lack of suitable processes for the isolation, characterisation and functionalisation of EVs. The aim of Ves4US is to develop a radically new platform for the efficient production and functionalisation of EVs, which will enable for their exploitation as tailor-made products in the fields of nanomedicine, cosmetics and nutraceutics. A core aspect of the project is to focus vesicles from an identified natural source, which could constitute a more economically viable and sustainable source of EVs. This will allow the development of natural nanocarriers with unprecedented abilities for drug delivery in specific tissues such as brain, lung, skin, dendritic or tumor cells. Ves4US is endorsed by prominent industrial stakeholders with strong interests in market-oriented innovation. The actively emerging field of EV-based research and industrial/clinical translation will significantly profit from the proposed VES4US innovation of focusing on natural nanovesicles; the new knowledge created will influence the biomedical landscape of the future both within and outside the European Union. The actively emerging field of EV-based research and industrial/clinical translation will significantly profit from the proposed VES4US innovation of focusing on natural source derived nanovesicles; the new knowledge created will influence the biomedical landscape of the future both within and outside the European Union.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-01-14 14:59:14
Dissemination and Communication Plan Documents, reports 2020-01-14 15:01:08
Quality Management system Documents, reports 2019-11-14 10:13:33
Website and Logo Websites, patent fillings, videos etc. 2019-11-14 10:13:31
Functionalization strategy report Documents, reports 2019-11-14 10:13:32
Training plan Documents, reports 2019-11-14 10:13:34
Gender Action Plan Documents, reports 2019-11-14 10:13:33

Take a look to the deliverables list in detail:  detailed list of VES4US deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 L. Mesarec, W. Góźdź, A. Iglič, V. Kralj-Iglič, E. G. Virga, S. Kralj
Normal red blood cells’ shape stabilized by membrane’s in-plane ordering
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56128-0
Scientific Reports 9/1 2020-01-30
2019 Christopher Stanly, Maneea Moubarak, Immacolata Fiume, Lilla Turiák, Gabriella Pocsfalvi
Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles
published pages: 6205, ISSN: 1422-0067, DOI: 10.3390/ijms20246205
International Journal of Molecular Sciences 20/24 2020-01-14
2020 Meiyu Gai, Johanna Simon, Ingo Lieberwirth, Volker Mailänder, Svenja Morsbach, Katharina Landfester
A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly
published pages: , ISSN: 1759-9954, DOI: 10.1039/c9py01136f
Polymer Chemistry 2020-01-14
2019 Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Vaccination with (1–11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice
published pages: , ISSN: 1720-8319, DOI: 10.1007/s40520-019-01414-0
Aging Clinical and Experimental Research 2020-01-14
2019 Mitja Drab, David Stopar, Veronika Kralj-Iglič, and Aleš Iglič
Inception Mechanisms of Tunneling Nanotubes
published pages: , ISSN: , DOI: 10.3390/cells8060626
2019-10-17
2019 Nadia Mazzarella, Ivana Giangrieco, Serena Visone, Pamela Santonicola, Jannis Achenbach, Giuseppina Zampi, Maurizio Tamburrini, Elia Di Schiavi, Maria Antonietta Ciardiello
Green kiwifruit extracts protect motor neurons from death in a spinal muscular atrophy model in Caenorhabditis elegans
published pages: 2327-2335, ISSN: 2048-7177, DOI: 10.1002/fsn3.1078
Food Science & Nutrition 7/7 2019-10-03
2019 Carolina Paganini, Umberto Capasso Palmiero, Gabriella Pocsfalvi, Nicolas Touzet, Antonella Bongiovanni, Paolo Arosio
Scalable Production and Isolation of Extracellular Vesicles: Available Sources and Lessons from Current Industrial Bioprocesses
published pages: 1800528, ISSN: 1860-6768, DOI: 10.1002/biot.201800528
Biotechnology Journal 2019-10-03
2019 Božič, Sitar, Junkar, Štukelj, Pajnič, Žagar, Kralj-Iglič, Kogej
Viscosity of Plasma as a Key Factor in Assessment of Extracellular Vesicles by Light Scattering
published pages: 1046, ISSN: 2073-4409, DOI: 10.3390/cells8091046
Cells 8/9 2019-10-03
2018 Clotilde Théry, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K Atkin-Smith, D Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N Bauer, Amy A Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Abderrahim Benmoussa, Anna
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
published pages: 1535750, ISSN: 2001-3078, DOI: 10.1080/20013078.2018.1535750
Journal of Extracellular Vesicles 7/1 2019-10-03

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