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AngioMature SIGNED

Mechanisms of vascular maturation and quiescence during development, homeostasis and aging

Total Cost €


EC-Contrib. €






 AngioMature project word cloud

Explore the words cloud of the AngioMature project. It provides you a very rough idea of what is the project "AngioMature" about.

epigenetic    angioarchitectural    human    adults    thereby    specification    differentiation    pathology    groundbreaking    functional    analyze    bone    pave    previously    expression    adolescence    endothelial    mice    ec    experimental    genome    sinusoidal    lining    sprouting    vital    yield    signatures    validate    active    signaling    marrow    single    create    types    employ    liver    capillaries    organotypic    transcriptome    organoid    methylation    omics    cell    structural    vascular    insights    mature    adult    angiomature    functionally    biology    characterizing    brain    aging    biological    cells    lung    conditional    mechanisms    vessel    angiogenesis    undergo    gene    screen    transcriptional    maintenance    maturation    matrix    quiescent    interdisciplinary    ecs    isolated    transformative    health    layer    newborn    unrecognized    mechanistic    stability    organotypically    inside    diverse    healthy    dna    culture    blood    continuous    resolution    gain    map    differentiated    vessels   

Project "AngioMature" data sheet

The following table provides information about the project.


Organization address
postcode: 69117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙338˙918 €
 EC max contribution 2˙338˙918 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Angiogenesis research has focused on the sprouting of new capillaries. The mechanisms of vessel maturation are much less well understood. Yet, the maintenance of a mature, quiescent, and organotypically-differentiated layer of endothelial cells (ECs) lining the inside of all blood vessels is vital for human health. The goal of ANGIOMATURE is to identify, validate, and implement novel mechanisms of vascular maturation and organotypic EC differentiation that are active during development, maintenance of vascular stability in adults, and undergo changes in aging. We recently identified previously unrecognized gene expression signatures of vascular maturation in a genome-wide screen of ECs isolated from newborn and adult mice. Epigenetic mechanisms were identified that control the EC transcriptome through gain and loss of DNA methylation as well as EC differentiation and signaling specification. These findings pave the way for groundbreaking novel opportunities to study vascular maturation. By characterizing functionally diverse types of blood vessels, including continuous ECs in lung and brain and sinusoidal ECs in liver and bone marrow, the ANGIOMATURE project will (1) determine up to single cell resolution the transcriptional and epigenetic program(s) of vascular maturation and organotypic differentiation during adolescence, (2) analyze the functional consequences of such program(s) in differentiated ECs and their adaptation to challenge, and (3) study changes of maturation and differentiation program(s) and vascular responses during aging. We will towards this end employ an interdisciplinary matrix of approaches involving omics, systems biology, conditional gene targeting, organoid cell culture, and experimental pathology to create a high-resolution structural and functional organotypic angioarchitectural map. The project will thereby yield transformative mechanistic insights into vital biological processes that are most important for human health and healthy aging.


year authors and title journal last update
List of publications.
2018 Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, Junhao Hu
Endothelial cell fitness dictates the source of regenerating liver vasculature
published pages: 2497-2508, ISSN: 0022-1007, DOI: 10.1084/jem.20180008
Journal of Experimental Medicine 215/10 2020-04-04

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The information about "ANGIOMATURE" are provided by the European Opendata Portal: CORDIS opendata.

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