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AngioMature SIGNED

Mechanisms of vascular maturation and quiescence during development, homeostasis and aging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AngioMature project word cloud

Explore the words cloud of the AngioMature project. It provides you a very rough idea of what is the project "AngioMature" about.

omics    biology    organoid    angioarchitectural    bone    dna    signaling    cell    culture    mature    resolution    vessel    epigenetic    screen    characterizing    validate    healthy    brain    thereby    vessels    differentiated    angiogenesis    vascular    organotypic    sinusoidal    transcriptional    newborn    adults    specification    cells    gain    gene    mechanistic    angiomature    blood    create    analyze    human    transformative    previously    insights    organotypically    yield    experimental    differentiation    adult    types    liver    groundbreaking    capillaries    map    stability    employ    sprouting    lining    quiescent    functionally    expression    single    ec    undergo    conditional    matrix    interdisciplinary    adolescence    unrecognized    biological    lung    transcriptome    inside    maturation    maintenance    mechanisms    ecs    genome    health    mice    aging    endothelial    methylation    active    continuous    diverse    vital    functional    structural    marrow    layer    signatures    pathology    pave    isolated   

Project "AngioMature" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙338˙918 €
 EC max contribution 2˙338˙918 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 1˙275˙000.00
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 1˙063˙918.00

Map

 Project objective

Angiogenesis research has focused on the sprouting of new capillaries. The mechanisms of vessel maturation are much less well understood. Yet, the maintenance of a mature, quiescent, and organotypically-differentiated layer of endothelial cells (ECs) lining the inside of all blood vessels is vital for human health. The goal of ANGIOMATURE is to identify, validate, and implement novel mechanisms of vascular maturation and organotypic EC differentiation that are active during development, maintenance of vascular stability in adults, and undergo changes in aging. We recently identified previously unrecognized gene expression signatures of vascular maturation in a genome-wide screen of ECs isolated from newborn and adult mice. Epigenetic mechanisms were identified that control the EC transcriptome through gain and loss of DNA methylation as well as EC differentiation and signaling specification. These findings pave the way for groundbreaking novel opportunities to study vascular maturation. By characterizing functionally diverse types of blood vessels, including continuous ECs in lung and brain and sinusoidal ECs in liver and bone marrow, the ANGIOMATURE project will (1) determine up to single cell resolution the transcriptional and epigenetic program(s) of vascular maturation and organotypic differentiation during adolescence, (2) analyze the functional consequences of such program(s) in differentiated ECs and their adaptation to challenge, and (3) study changes of maturation and differentiation program(s) and vascular responses during aging. We will towards this end employ an interdisciplinary matrix of approaches involving omics, systems biology, conditional gene targeting, organoid cell culture, and experimental pathology to create a high-resolution structural and functional organotypic angioarchitectural map. The project will thereby yield transformative mechanistic insights into vital biological processes that are most important for human health and healthy aging.

 Publications

year authors and title journal last update
List of publications.
2018 Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, Junhao Hu
Endothelial cell fitness dictates the source of regenerating liver vasculature
published pages: 2497-2508, ISSN: 0022-1007, DOI: 10.1084/jem.20180008
Journal of Experimental Medicine 215/10 2020-04-04

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