Opendata, web and dolomites

BASILIC SIGNED

Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BASILIC project word cloud

Explore the words cloud of the BASILIC project. It provides you a very rough idea of what is the project "BASILIC" about.

triggers    clonal    levels    physiology    convey    experimental    costimulator    ox40    addicted    tuned    tnfr    lat    pay    signaling    expansion    proteomics    satisfying    think    functions    novelty    multiple    decisions    dynamics    optimal    nature    although    combining    ideal    genetic    coinhibitory    costimulators    presenting    superfamily    cooperate    cd28    tumoral    coinhibitor    superseded    harmful    probe    cells    negative    receptor    signals    disrupt    receptors    molecular    ignored    fundamental    costimulatory    favorable    sole    decode    places    unveil    comprehension    understand    central    epigenomics    immunopathologies    coinhibitors    ing    pathogenic    stoichiometry    integrate    computational    tcr    occupies    malfunctions    inputs    capacity    creates    primary    informed    signalosomes    plays    lack    multidisciplinary    hub    severe    informations    methodology    anti    autistic    stems    cell    crosstalk    place    isolation    pd    positive    straddling    scales    largely    situation    architecture    organismal    encounters    antigen    inflammatory   

Project "BASILIC" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙000˙000.00

Map

 Project objective

Although the T cell antigen receptor (TCR) occupies a central place in T cell physiology, it does not work in isolation and the signals it triggers are tuned by receptors that convey positive (costimulators) and negative (coinhibitors) informations. We lack a satisfying comprehension of the way T cells integrate such multiple inputs to make informed decisions. The proteomics-based methodology we developed around the TCR places us in a favorable situation to decode at systems-level the crosstalk between the TCR, the CD28 costimulator and the PD-1 coinhibitor signaling pathways. The novelty of our approach stems from (1) its use of primary T cells, (2) its capacity to probe the architecture and dynamics of signalosomes resulting from T cell-antigen presenting cell encounters, (3) the attention we pay to the stoichiometry of the studied signalosomes, a key parameter largely ignored in previous studies, and (4) its multidisciplinary nature straddling molecular and organismal scales. Our specific aims are: Aim 1. To understand how the TCR and CD28 signaling pathways cooperate to achieve optimal T cell responses. Aim 2. To determine whether CD28 is the sole target of the PD-1 coinhibitor. Aim 3. To determine how under inflammatory conditions CD28 functions can be superseded by those of OX40, a costimulator of the TNFR superfamily. Aim 4. To unveil how malfunctions of LAT, a key signaling hub used by the TCR, disrupt the TCR-CD28 crosstalk and result in unique pathogenic T cells that by becoming ‘autistic’ to TCR signals and addicted to CD28 signals lead to severe immunopathologies. We think that combining genetic, epigenomics, proteomics, and computational approaches creates ideal experimental conditions to understand at system-levels how TCR, costimulatory, coinhibitory and inflammatory signals are integrated during T cell clonal expansion. Although of fundamental nature, our project should help understanding the harmful role PD-1 plays during anti-tumoral responses.

 Publications

year authors and title journal last update
List of publications.
2019 Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
published pages: 1530-1541, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0489-8
Nature Immunology 20/11 2020-04-24
2019 Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen
Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy
published pages: 3315-3330.e7, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.05.041
Cell Reports 27/11 2019-09-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BASILIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BASILIC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

TAMING CORROSION (2020)

Towards mastering the long-standing challenge of ageing infrastructures in corrosive environments

Read More  

DeCoCt (2019)

Knowledge based design of complex synthetic microbial communities for plant protection

Read More