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EvoTrap SIGNED

Mechanisms to emerge and replicate the first sequence information of life in geothermal microfluidics of early Earth

Total Cost €

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EC-Contrib. €

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Partnership

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 EvoTrap project word cloud

Explore the words cloud of the EvoTrap project. It provides you a very rough idea of what is the project "EvoTrap" about.

hypercycle    can    interesting    ligation    200mbar    tof    flows    fast    recondensation    boundary    mimick    progressing    edc    settings    base    capillary    microfluidics    taq    interfaces    activated    monitor    illumina    metabolism    dynamics    cooperative    biochemistry    convection    autonomous    boiling    accumulated    water    ms    below    mechanisms    polymerization    heat    atp    lt    rna    first    small    richert    molecules    gradients    lc    food    pressure    boost    microfluidic    temperature    chemistry    800    deg    replication    oligonucleotides    szostak    ligase    trigger    life    rock    strands    air    fog    select    bind    respective    hydro    oligonucleotide    reconstruct    60    lab    gelation    expertise    prebiotic    onset    joyce    host    evolution    mimicking    accumulate    selective    equilibrium    ribozymes    starting    chemistries    thermal    molecular    emergence    earth    pressures    dna    modern    thermophoresis    sequencing    heated    adp    creation    explored    primitive    separated    expand    3d    nbsp    tested    pores    drive    sequences    printed    gradient    fold    limited    explore    enhanced    forms    sequence   

Project "EvoTrap" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙364˙500 €
 EC max contribution 2˙364˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙364˙500.00

Map

 Project objective

Can we reconstruct in the lab the onset of molecular evolution? To trigger the autonomous emergence of the first oligonucleotide sequences, we will explore non-equilibrium boundary conditions and selective mechanisms to host the fast progressing prebiotic replication chemistry of oligonucleotides. We will explore novel water-fog microfluidic settings to boost the replication and selection of the first RNA sequences. The findings aims to enable the creation of primitive life forms in the lab, starting from simple molecules in heated rock pores of early Earth.

Autonomous replication and metabolism. We will expand our thermal gradient expertise to host three replication chemistries. Using 3D printed microfluidics, we will mimick conditions in pores on early Earth. Thermophoresis will select long over short strands, accumulate small food molecules and strands will be separated by thermal convection and novel mechanisms in water-air systems. With respective collaboration partners, we will drive the replication from RNA ribozymes (Joyce), base-by-base RNA replication (Szostak) and EDC activated DNA ligation (Richert) and monitor the results with Illumina sequencing and TOF LC/MS. The ligation will be also explored with Taq ligase since we expect a cooperative replication dynamics with hypercycle-like characteristics. Thermal gradients will drive early metabolism to boost RNA polymerization and select ATP over ADP to drive modern biochemistry.

Sequence selection in low pressure water-air systems. Oligonucleotides bind to water-air interfaces. and can be accumulated 800-fold by heat-driven capillary flows. Based on this, we expect interesting selection effects under microfluidic boiling, fog formation and recondensation dynamics. The settings are tested for sequence selective hydro-gelation of RNA/DNA and enhanced replication chemistry. The temperature of boiling water will be limited below 60°C by using air pressures <200mbar, mimicking very early Earth conditions.

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The information about "EVOTRAP" are provided by the European Opendata Portal: CORDIS opendata.

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