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EvoTrap SIGNED

Mechanisms to emerge and replicate the first sequence information of life in geothermal microfluidics of early Earth

Total Cost €

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EC-Contrib. €

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Partnership

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 EvoTrap project word cloud

Explore the words cloud of the EvoTrap project. It provides you a very rough idea of what is the project "EvoTrap" about.

equilibrium    biochemistry    hypercycle    metabolism    boundary    host    microfluidics    earth    modern    lt    tof    richert    microfluidic    progressing    boiling    below    deg    pores    food    adp    boost    60    ligase    selective    life    onset    polymerization    ribozymes    taq    interesting    fog    mimicking    monitor    respective    forms    gradient    recondensation    sequence    small    select    limited    creation    sequencing    oligonucleotides    evolution    rna    mimick    edc    mechanisms    lc    fast    ligation    pressures    heated    primitive    thermal    explored    szostak    interfaces    3d    capillary    rock    molecular    expertise    illumina    thermophoresis    air    dynamics    cooperative    chemistries    trigger    accumulated    first    starting    pressure    explore    oligonucleotide    joyce    heat    water    gradients    can    atp    expand    accumulate    hydro    enhanced    drive    base    reconstruct    printed    bind    chemistry    lab    prebiotic    200mbar    nbsp    temperature    emergence    dna    replication    strands    settings    activated    800    tested    gelation    autonomous    separated    sequences    ms    molecules    flows    fold    convection   

Project "EvoTrap" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙364˙500 €
 EC max contribution 2˙364˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙364˙500.00

Map

 Project objective

Can we reconstruct in the lab the onset of molecular evolution? To trigger the autonomous emergence of the first oligonucleotide sequences, we will explore non-equilibrium boundary conditions and selective mechanisms to host the fast progressing prebiotic replication chemistry of oligonucleotides. We will explore novel water-fog microfluidic settings to boost the replication and selection of the first RNA sequences. The findings aims to enable the creation of primitive life forms in the lab, starting from simple molecules in heated rock pores of early Earth.

Autonomous replication and metabolism. We will expand our thermal gradient expertise to host three replication chemistries. Using 3D printed microfluidics, we will mimick conditions in pores on early Earth. Thermophoresis will select long over short strands, accumulate small food molecules and strands will be separated by thermal convection and novel mechanisms in water-air systems. With respective collaboration partners, we will drive the replication from RNA ribozymes (Joyce), base-by-base RNA replication (Szostak) and EDC activated DNA ligation (Richert) and monitor the results with Illumina sequencing and TOF LC/MS. The ligation will be also explored with Taq ligase since we expect a cooperative replication dynamics with hypercycle-like characteristics. Thermal gradients will drive early metabolism to boost RNA polymerization and select ATP over ADP to drive modern biochemistry.

Sequence selection in low pressure water-air systems. Oligonucleotides bind to water-air interfaces. and can be accumulated 800-fold by heat-driven capillary flows. Based on this, we expect interesting selection effects under microfluidic boiling, fog formation and recondensation dynamics. The settings are tested for sequence selective hydro-gelation of RNA/DNA and enhanced replication chemistry. The temperature of boiling water will be limited below 60°C by using air pressures <200mbar, mimicking very early Earth conditions.

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The information about "EVOTRAP" are provided by the European Opendata Portal: CORDIS opendata.

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