Opendata, web and dolomites


Elucidating the molecular and biophysical mechanism of coral calcification in view of the future acidified ocean

Total Cost €


EC-Contrib. €






 Ca2Coral project word cloud

Explore the words cloud of the Ca2Coral project. It provides you a very rough idea of what is the project "Ca2Coral" about.

spectroscopic    enigmatic    ph    holobiont    unless    nucleation    equilibrium    geochemist    pistillata    proteins    calcification    organic    decades    organisms    stylophora    otherwise    responsible    genomics    projected    precipitation    ignored    core    aragonite    coral    skeletal    below    exposed    line    biomineralisation    vivo    calcify    co2    hypothesis    adult    functional    genes    ultra    vitro    scenarios    mechanism    cloned    inquiry    ca2coral    precursor    thermodynamic    emerged    matrix    resolution    genetics    emissions    precipitate    calcium    roles    mineral    lines    biophysical    larval    considerations    levels    2100    group    stony    zooxanthellate    wounded    concentrate    chemistry    anions    models    clear    combination    molecular    reaction    continue    skeleton    carbonate    although       cell    sufficient    basic    expression    compartments    material    elucidate    imaging    seawater    acidic    parallel    genomic    corals    ions    largely    biological   

Project "Ca2Coral" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 31905

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙499˙741 €
 EC max contribution 1˙499˙741 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF HAIFA IL (HAIFA) coordinator 1˙499˙741.00


 Project objective

Although various aspects of biomineralisation in corals have been studied for decades, the basic mechanism of precipitation of the aragonite skeleton remains enigmatic. Two parallel lines of inquiry have emerged: geochemist models of calcification that are directly related to seawater carbonate chemistry at thermodynamic equilibrium. Here, the role of the organisms in the precipitation reaction is largely ignored. The second line is based on biological considerations of the biomineralisation process, which focuses on models of biophysical processes far from thermodynamic equilibrium that concentrate calcium ions, anions and proteins responsible for nucleation in specific compartments. Recently, I identified and cloned a group of highly acidic proteins derived the common stony coral, Stylophora pistillata. All of the cloned proteins precipitate aragonite in seawater at pH 8.2 and 7.6 in-vitro. However, it is not at all clear if the expression of these proteins in-vivo is sufficient for the formation of an aragonite skeleton at seawater pH values below ~7.8. Here using a combination of molecular, biophysical, genomic, and cell biological approaches, we proposed to test the core hypothesis that, unless wounded or otherwise having skeletal material exposed directly to seawater, stony zooxanthellate corals will continue to calcify at pH values projected for the CO2 emissions scenarios for 2100. Specifically, the objectives of Ca2Coral are to: 1) Use functional genomics to identify the key genes and proteins involved both in the organic matrix and skeleton formation in the adult holobiont and during its larval development. 2) Use a genetics approach to elucidate the roles of specific proteins in the biomineralisation process. 3) Use ultra-high resolution imaging and spectroscopic analysis at different pH levels to elucidate the biomineralisation pathways and mineral precursor in corals in the adult holobiont and during its larval development.


year authors and title journal last update
List of publications.
2019 Ra\'anan Laipnik, Veronica Bissi, Chang-Yu Sun, Giuseppe Falini, Pupa U.P.A. Gilbert, Tali Mass
Coral acid rich protein selects vaterite polymorph in vitro
published pages: 107431, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2019.107431
Journal of Structural Biology 2020-01-29
2018 Anat Akiva, Maayan Neder, Keren Kahil, Rotem Gavriel, Iddo Pinkas, Gil Goobes, Tali Mass
Minerals in the pre-settled coral Stylophora pistillata crystallize via protein and ion changes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04285-7
Nature Communications 9/1 2019-11-11
2019 Maayan Neder, Pierre Philippe Laissue, Anat Akiva, Derya Akkaynak, Marie Albéric, Oliver Spaeker, Yael Politi, Iddo Pinkas, Tali Mass
Mineral formation in the primary polyps of pocilloporoid corals
published pages: 631-645, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.07.016
Acta Biomaterialia 96 2019-11-11

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