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ASSYSt SIGNED

A reliable CXCL4 biomarker assay to improve diagnosis and treatment of Systemic Sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ASSYSt project word cloud

Explore the words cloud of the ASSYSt project. It provides you a very rough idea of what is the project "ASSYSt" about.

biomarker    medical    organs    tract    vitro    sclerosis    irrespective    levels    tissue    therapeutic    starting    patients    experiments    predict    circumvent    assay    complicates    business    prohibits    market    protocols    die    player    molecular    erc    suggest    strategies    cheap    outcome    labs    circulating    complications    excessive    treatments    argue    replication    skin    disorder    prevention    organ    diagnosis    matrix    tool    sensitive    aetiology    demonstrated    fast    deposition    assessing    measuring    assist    ssc    extracellular    complement    grant    autoimmune    multiple    exacerbated    guide    disease    markers    lack    lung    strategy    joints    of    accelerate    pathogenesis    cohorts    lacking    scleroderma    ultimately    treatment    course    half    unclear    central    systemic    clinical    kidneys    accessible    gastrointestinal    decision    team    collection    storage    chemokine    route    cxcl4    internal    heart    assyst    fibrosis    scarring    prognosis    listed    culminating    adequately    curative    diagnostic    validate   

Project "ASSYSt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 150˙000.00

Map

 Project objective

Systemic Sclerosis (SSc, scleroderma) is a complex autoimmune disorder of unclear aetiology, culminating in excessive extracellular matrix deposition (fibrosis/tissue scarring) in skin and internal organs (e.g. joints, heart, lung, gastrointestinal tract and kidneys). More than half of the patients will ultimately die as a result of organ complications. The medical need is exacerbated by the lack of curative treatments and the lack of specific and sensitive molecular markers to facilitate reliable diagnosis and prognosis.

My team has recently demonstrated, through research funded by the ERC Starting Grant CIRCUMVENT, that the chemokine CXCL4 is a central player in the pathogenesis of SSc. Our results suggest that CXCL4 has great potential as 1) a biomarker to assist early diagnosis, 2) a biomarker to predict SSc disease course, and 3) a therapeutic target for the treatment or prevention of fibrosis in patients with SSc. Currently, a robust, accessible, reliable, cheap and fast assay to determine CXCL4 levels for clinical use is lacking. This prohibits the use of CXCL4 to predict clinical and treatment outcome and complicates the large-scale replication experiments across multiple labs and cohorts that are necessary to validate the diagnostic value of CXCL4.

Therefore, we argue that a reliable in vitro assay measuring circulating CXCL4 levels is highly needed and can be deployed as a research support tool to accelerate the implementation of clinical strategies based on CXCL4 and a clinical decision support tool in SSc to complement current diagnostic protocols. ASSYSt will focus on 1) the development of a reliable assay to adequately determine circulating CXCL4 levels irrespective of sample collection and storage conditions, 2) assessing the market potential of each of the applications listed above, and 3) defining a strong business strategy to guide route to market.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASSYST" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASSYST" are provided by the European Opendata Portal: CORDIS opendata.

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