Opendata, web and dolomites


Towards understanding non-canonical phosphatidylinositol kinases in the maintenance of prostate metabolism.

Total Cost €


EC-Contrib. €






Project "PCAPIP" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00


 Project objective

As a result of it’s specialized secretory functions, the prostate has a unique biology that makes it prone to the development of cancer. Specifically, a strong dependence on hormonal stimulation through the androgen receptor (AR) pathway that is implicated in driving downstream changes to the central metabolism of the cell. To find answers to clinical questions, I am delving into the fundamental mechanisms of a previously overlooked family of lipid kinases. The type II phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) are responsible for regulating a proportion of phospholipid species found embedded in the membranes of various cellular organelles. Intricate differences of the composition of these membranes can have a major effect on the regulation of cell cycle, metabolite trafficking, growth and survival. Herein, I outline a basic examination of the PI5P4Ks that will establish the first understanding of their phenotypic importance in prostate cells. There is reason to believe that these enzymes are critical regulators of the AR pathway that may be a trafficking conduit for changes to AR regulated metabolites. To test this, I am generating the first prostate-specific PI5P4K knock-out mouse model. A state-of-the-art metabolomic evaluation of both this animal model and a collection of human cell models will uncover the ultimate relevance of the PI5P4Ks in prostate biology. The proposed study will provide valuable insights into a non-canonical family of kinases that could lay the groundwork their development as novel drug targets.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PCAPIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PCAPIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EPIC (2019)

Evolution of Planktonic Gastropod Calcification

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More