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TETCOLON SIGNED

Dissecting the role of the epigenetic regulator TET2 in colorectal cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 TETCOLON project word cloud

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5mc    genes    molecular    cell    perturbed    methylcytosine    disciplinary    colonic    virtually    oncogenic    epigenomic    epigenetic    deficiency    3d    epigenome    link    contributes    tumor    methylome    therapies    reprogramming    pathological    ultimately    carcinogenesis    cancer    aberrantly    therapeutic    revealed    contain    preliminary    hydroxymethylcytosine    cutting    tissue    stability    normal    rna    active    significance    probe    basic    human    driver    epithelial    mediated    translocation    innovative    correlations    helping    protein    biology    oxidize    genetic    suggests    methylation    cells    colorectal    edge    knockdown    transcriptome    tet    patterns    bioinformatics    instability    mutational    deficient    event    bystander    culture    epigenetics    5mcs    accumulation    load    tet2    mechanism    tet1    dna    combining    genomic    levels    mrna    methylated    clear    crcs    5hmc    vulnerabilities    indicates    seq    causal    biomarker    epi    induces    techniques    translational    suppression    family    eleven    expression    predicts    ten    survival    crc    supporting    mouse    defects    clinico    dioxygenases    demethylation    pathogenesis    elucidate    predictive    oxidized   

Project "TETCOLON" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PAVIA 

Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100
website: www.unipv.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 183˙473.00

Map

 Project objective

Colorectal cancer (CRC) results from the accumulation of genetic and epigenetic changes in colonic epithelial cells. Epigenome studies revealed that virtually all CRCs contain aberrantly methylated genes and perturbed methylation patterns. Ten-Eleven Translocation (TET) protein family dioxygenases oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further to other oxidized 5mCs, supporting active DNA demethylation and helping maintain epigenomic stability. Loss of TET1 is an oncogenic driver in some CRCs. My preliminary analysis indicates that human CRCs have low TET2 mRNA levels compared to normal colorectal tissue, and suggests that low TET2 expression predicts increased mutational load and reduced overall survival. However, whether TET2 deficiency contributes to CRC pathogenesis, or represents a bystander event, remains to be established. In this proposal, I will elucidate the role of TET2 in CRC pathogenesis by testing whether TET2 knockdown induces methylome and transcriptome reprogramming, ultimately promoting (epi)genomic instability and tumor growth. I will also investigate correlations between TET2 defects and molecular/clinico-pathological parameters, and probe TET2 expression as predictive biomarker of response to CRC therapies. With these aims, I will use a multi-disciplinary approach, combining cell biology, cancer epigenetics, bioinformatics, human and mouse studies with cutting-edge techniques such as 3D cell culture and RNA-seq. This study should establish a clear causal link between TET2 loss and CRC pathogenesis, providing new insight into the mechanism of TET2-mediated tumor suppression and leading to the development of innovative therapies that exploit vulnerabilities of TET2-deficient CRC cells. Overall, this project has both basic and translational significance, and the potential to advance our understanding of CRC carcinogenesis and therapeutic response.

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The information about "TETCOLON" are provided by the European Opendata Portal: CORDIS opendata.

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