Opendata, web and dolomites

TETCOLON SIGNED

Dissecting the role of the epigenetic regulator TET2 in colorectal cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TETCOLON project word cloud

Explore the words cloud of the TETCOLON project. It provides you a very rough idea of what is the project "TETCOLON" about.

rna    genetic    reprogramming    tet1    cutting    expression    epigenetic    deficiency    oxidize    crcs    disciplinary    predicts    mutational    patterns    demethylation    tumor    carcinogenesis    methylome    innovative    pathological    instability    accumulation    epigenomic    significance    therapeutic    helping    5hmc    clinico    suppression    epithelial    defects    supporting    culture    mouse    link    tet    perturbed    genes    human    indicates    combining    seq    oncogenic    load    colorectal    cancer    protein    vulnerabilities    correlations    causal    elucidate    virtually    contributes    biology    revealed    driver    knockdown    hydroxymethylcytosine    bystander    molecular    5mc    3d    genomic    family    therapies    methylated    suggests    5mcs    methylation    dna    ten    mechanism    pathogenesis    techniques    probe    deficient    active    cells    induces    levels    eleven    preliminary    methylcytosine    bioinformatics    colonic    epigenetics    biomarker    clear    tissue    epi    translocation    dioxygenases    normal    survival    mrna    cell    mediated    transcriptome    predictive    translational    tet2    edge    aberrantly    crc    contain    oxidized    ultimately    stability    event    basic    epigenome   

Project "TETCOLON" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PAVIA 

Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100
website: www.unipv.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 183˙473.00

Map

 Project objective

Colorectal cancer (CRC) results from the accumulation of genetic and epigenetic changes in colonic epithelial cells. Epigenome studies revealed that virtually all CRCs contain aberrantly methylated genes and perturbed methylation patterns. Ten-Eleven Translocation (TET) protein family dioxygenases oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further to other oxidized 5mCs, supporting active DNA demethylation and helping maintain epigenomic stability. Loss of TET1 is an oncogenic driver in some CRCs. My preliminary analysis indicates that human CRCs have low TET2 mRNA levels compared to normal colorectal tissue, and suggests that low TET2 expression predicts increased mutational load and reduced overall survival. However, whether TET2 deficiency contributes to CRC pathogenesis, or represents a bystander event, remains to be established. In this proposal, I will elucidate the role of TET2 in CRC pathogenesis by testing whether TET2 knockdown induces methylome and transcriptome reprogramming, ultimately promoting (epi)genomic instability and tumor growth. I will also investigate correlations between TET2 defects and molecular/clinico-pathological parameters, and probe TET2 expression as predictive biomarker of response to CRC therapies. With these aims, I will use a multi-disciplinary approach, combining cell biology, cancer epigenetics, bioinformatics, human and mouse studies with cutting-edge techniques such as 3D cell culture and RNA-seq. This study should establish a clear causal link between TET2 loss and CRC pathogenesis, providing new insight into the mechanism of TET2-mediated tumor suppression and leading to the development of innovative therapies that exploit vulnerabilities of TET2-deficient CRC cells. Overall, this project has both basic and translational significance, and the potential to advance our understanding of CRC carcinogenesis and therapeutic response.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TETCOLON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TETCOLON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More