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ACORN SIGNED

Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ACORN" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙000˙000 €
 EC max contribution 1˙000˙000 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-05-2017-Twinning
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 353˙750.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 216˙250.00
3    PERCUROS BV NL (LEIDEN) participant 215˙000.00
4    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 85˙000.00
5    BIERAU SCHMEISER KATJA IT (VELLETRI) participant 65˙000.00
6    DE MARCHIS VERONICA IT (COLLEFERRO) participant 65˙000.00

Map

 Project objective

Carbon monoxide (CO) has gathered increasing attention because of its role as a gasotransmitter with therapeutic and cell-protective effects. It is also recognised as a cell-signalling molecule where recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application have shown their importance with respect to delivery of such agents to their respective targets. However, despite their promise, their remains two major bottlenecks that may prevent these compounds from reaching the clinic. Firstly, the precise spatial-temporal CO release of CORMs is not target-specific. The CO molecule is highly diffusive and binds to haemoproteins, which are ubiquitous. Secondly, CORMs are made of metal carbonyl complexes and as organometallic compounds, there is the potential of heavy metal toxicity. Moreover, since CORMs are water-soluble they are distributed throughout the body, which can lead to further increased toxicities against healthy tissues. Our project aims to alleviate some of the problems of CORMs by a) developing a method to monitor CO release by MRI and optical imaging; b) reformulate CORMs by encapsulating inside nanomaterials (specifically the FDA approved PLGA as a nanocarrier) and c) provide targeting of the CORMs to their site of delivery by conjugating peptide targeting moieties to the surface of the PLGA nanoparticle. Through the completion of these activities, I;;, supported by its twinning partners, is in the best position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

 Deliverables

List of deliverables.
Launch of website Websites, patent fillings, videos etc. 2020-04-02 20:43:27
Development of the project logo/brand Websites, patent fillings, videos etc. 2020-04-02 20:43:18
Brochure and flyer development Websites, patent fillings, videos etc. 2020-04-02 20:43:40

Take a look to the deliverables list in detail:  detailed list of ACORN deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies
published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050
Journal of Controlled Release 2020-04-15
2020 Tiago Rodrigues, Gonçalo J.L. Bernardes
Machine learning for target discovery in drug development
published pages: 16-22, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.10.003
Current Opinion in Chemical Biology 56 2020-02-05
2019 Charlotte Baker, Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J.L. Bernardes
Natural product–drug conjugates for modulation of TRPV1-expressing tumors
published pages: 2531-2536, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.025
Bioorganic & Medicinal Chemistry 27/12 2020-02-05
2019 Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Computational advances in combating colloidal aggregation in drug discovery
published pages: 402-418, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0234-9
Nature Chemistry 11/5 2020-02-05

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The information about "ACORN" are provided by the European Opendata Portal: CORDIS opendata.

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