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ACORN SIGNED

Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Total Cost €

EC-Contrib. €

Partnership

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ACORN project word cloud

Explore the words cloud of the ACORN project. It provides you a very rough idea of what is the project "ACORN" about.

monitor respective respect recognised plga healthy site distributed ubiquitous capability molecule corms carbon competitive inside shown temporal precise reaching imaging area soluble cell toxicities materials carbonyl firstly promise position organometallic health signalling release spatial claiming tissues despite therapeutic internationally conjugating co monoxide diffusive nanocarrier moieties excellence surface compete business protective stakeholders creation heavy peptide made compounds releasing secondly fda approved imm completion agents haemoproteins gathered twinning innovation clinic toxicity metal reformulate molecules body alleviate complexes binds water mri encapsulating prevent nanoparticle optical gasotransmitter nanomaterials networks bottlenecks

Project "ACORN" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	1˙000˙000 €
EC max contribution	1˙000˙000 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-05-2017-Twinning
Funding Scheme	CSA
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	353˙750.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	216˙250.00
3	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	215˙000.00
4	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	85˙000.00
5	BIERAU SCHMEISER KATJA BIERAU SCHMEISER KATJA Organization address address: VIA COLLE SAN FRANCESCO 7 city: VELLETRI postcode: 49 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VELLETRI)	participant	65˙000.00
6	DE MARCHIS VERONICA DE MARCHIS VERONICA Organization address address: VIA TIZIANO 14 city: COLLEFERRO postcode: 34 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (COLLEFERRO)	participant	65˙000.00

Map

Project objective

Carbon monoxide (CO) has gathered increasing attention because of its role as a gasotransmitter with therapeutic and cell-protective effects. It is also recognised as a cell-signalling molecule where recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application have shown their importance with respect to delivery of such agents to their respective targets. However, despite their promise, their remains two major bottlenecks that may prevent these compounds from reaching the clinic. Firstly, the precise spatial-temporal CO release of CORMs is not target-specific. The CO molecule is highly diffusive and binds to haemoproteins, which are ubiquitous. Secondly, CORMs are made of metal carbonyl complexes and as organometallic compounds, there is the potential of heavy metal toxicity. Moreover, since CORMs are water-soluble they are distributed throughout the body, which can lead to further increased toxicities against healthy tissues. Our project aims to alleviate some of the problems of CORMs by a) developing a method to monitor CO release by MRI and optical imaging; b) reformulate CORMs by encapsulating inside nanomaterials (specifically the FDA approved PLGA as a nanocarrier) and c) provide targeting of the CORMs to their site of delivery by conjugating peptide targeting moieties to the surface of the PLGA nanoparticle. Through the completion of these activities, I;;, supported by its twinning partners, is in the best position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

Deliverables

List of deliverables.
Launch of website	Websites, patent fillings, videos etc.	2020-04-02 20:43:27
Development of the project logo/brand	Websites, patent fillings, videos etc.	2020-04-02 20:43:18
Brochure and flyer development	Websites, patent fillings, videos etc.	2020-04-02 20:43:40

Take a look to the deliverables list in detail: detailed list of ACORN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien GarcÃa-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050	Journal of Controlled Release	2020-04-15
2020	Tiago Rodrigues, GonÃ§alo J.L. Bernardes Machine learning for target discovery in drug development published pages: 16-22, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.10.003	Current Opinion in Chemical Biology 56	2020-02-05
2019	Charlotte Baker, Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, GonÃ§alo J.L. Bernardes Natural productâ€“drug conjugates for modulation of TRPV1-expressing tumors published pages: 2531-2536, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.025	Bioorganic & Medicinal Chemistry 27/12	2020-02-05
2019	Daniel Reker, GonÃ§alo J. L. Bernardes, Tiago Rodrigues Computational advances in combating colloidal aggregation in drug discovery published pages: 402-418, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0234-9	Nature Chemistry 11/5	2020-02-05

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The information about "ACORN" are provided by the European Opendata Portal: CORDIS opendata.