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Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

Total Cost €


EC-Contrib. €






Project "DelNAM" data sheet

The following table provides information about the project.


Organization address
city: PORTO
postcode: 4099 002

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 960˙853 €
 EC max contribution 960˙853 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-05-2017-Twinning
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 475˙978.00
2    SYDDANSK UNIVERSITET DK (ODENSE M) participant 246˙125.00
3    UNIVERSITEIT GENT BE (GENT) participant 238˙750.00


 Project objective

DelNAM aims at Strengthening the Research Area of Delivery of Nucleic Acid Mimics (NAMS) into bacteria to fight the antibiotic crisis. This will be achieved by twinning the Faculty of Engineering of the University of Porto (FEUP) with outstanding EU institutions with high expertise in the areas of NAMs development and nanodelivery strategies. DelNAM will allow the development of a consolidated strategic research approach and a set of guidelines for exploitation and commercialization of the results that will have a strong regional, national and European impact. The proposal integrates synergies in complementary fields of research that include nanotechnology, synthetic chemistry, microbiology and bioprocess modelling, aiming to obtain scientific breakthroughs that can improve the global health and economy.

The objectives of this proposal are in line with the specific challenge and scope of the topic H2020-WIDESPREAD-2016-2017 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. This challenge is addressed by twinning FEUP with 2 leading EU research institutions: University of Southern Denmark (SDU), in Odense, Denmark, a global leader in the development and invention of novel NAMs for gene therapy. They contribute with their extensive experience on the synthesis, structural studies and molecular modelling of NAMs; Ghent University (UGhent), in Belgium, an internationally-recognized laboratory for its excellence in the field of nanomedicines for the delivery of drugs and, in particular, nucleic acids. They provide decisive expertise on the design of delivery systems for nucleic acids and their behavior in native biological fluids.


List of deliverables.
Website and social media sites Websites, patent fillings, videos etc. 2020-03-09 16:07:20
Annual report on high impact publications Documents, reports 2020-03-09 16:07:19

Take a look to the deliverables list in detail:  detailed list of DelNAM deliverables.


year authors and title journal last update
List of publications.
2016 Sílvia Fontenete, Daniel Carvalho, Nuno Guimarães, Pedro Madureira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Application of locked nucleic acid-based probes in fluorescence in situ hybridization
published pages: 5897-5906, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7429-4
Applied Microbiology and Biotechnology 100/13 2019-10-08
2017 Rita S. Santos, George R. Dakwar, Elisa Zagato, Toon Brans, Céu Figueiredo, Koen Raemdonck, Nuno F. Azevedo, Stefaan C. De Smedt, Kevin Braeckmans
Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus
published pages: 1-12, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.05.029
Biomaterials 138 2019-10-08
2017 Andreia S. Azevedo, Carina Almeida, Luciana C. Gomes, Carla Ferreira, Filipe J. Mergulhão, Luís F. Melo, Nuno F. Azevedo
An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium
published pages: 64-69, ISSN: 1369-703X, DOI: 10.1016/j.bej.2016.11.013
Biochemical Engineering Journal 118 2019-10-08
2015 Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo
Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori
published pages: e269, ISSN: 2162-2531, DOI: 10.1038/mtna.2015.46
Molecular Therapy - Nucleic Acids 4 2019-10-08
2016 Sílvia Fontenete, Marina Leite, Davie Cappoen, Rita Santos, Chris Van Ginneken, Céu Figueiredo, Jesper Wengel, Paul Cos, Nuno Filipe Azevedo
Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model
published pages: e0148353, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0148353
PLOS ONE 11/2 2019-10-08
2016 Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Luís F. Melo, Nuno F. Azevedo
Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents
published pages: 227-241, ISSN: 0892-7014, DOI: 10.1080/08927014.2015.1124096
Biofouling 32/3 2019-10-08
2016 Sílvia Fontenete, Nuno Guimarães, Jesper Wengel, Nuno Filipe Azevedo
Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models
published pages: 1-12, ISSN: 0738-8551, DOI: 10.3109/07388551.2014.993589
Critical Reviews in Biotechnology 2019-10-08
2015 Fontenete Silvia, Barros Joana, Madureira Pedro, Figueiredo Céu, Wengel Jesper, Azevedo Nuno Filipe
Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids
published pages: 3961-3969, ISSN: 0175-7598, DOI: 10.1007/s00253-015-6389-4
Applied Microbiology and Biotechnology 99/9 2019-10-08
2016 Luzia Mendes, Rui Rocha, Andreia Sofia Azevedo, Catarina Ferreira, Mariana Henriques, Miguel Gonçalves Pinto, Nuno Filipe Azevedo
Novel strategy to detect and locate periodontal pathogens: The PNA-FISH technique
published pages: 185-191, ISSN: 0944-5013, DOI: 10.1016/j.micres.2016.07.002
Microbiological Research 192 2019-10-08
2015 Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Pedro Madureira, Jesper Wengel, Nuno F. Azevedo
Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)
published pages: 64-73, ISSN: 1369-703X, DOI: 10.1016/j.bej.2015.04.024
Biochemical Engineering Journal 104 2019-10-08
2016 Rui Rocha, Rita S. Santos, Pedro Madureira, Carina Almeida, Nuno F. Azevedo
Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: The effect of pH, dextran sulfate and probe concentration
published pages: 1-7, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2016.03.047
Journal of Biotechnology 226 2019-10-08
2017 Susana P. Lopes, Daniel T. Carvalho, Maria O. Pereira, Nuno F. Azevedo
Discriminating typical and atypical cystic fibrosis-related bacteria by multiplex PNA-FISH
published pages: 355-367, ISSN: 0006-3592, DOI: 10.1002/bit.26085
Biotechnology and Bioengineering 114/2 2019-10-08
2015 Sílvia Fontenete, Marina Leite, Nuno Guimarães, Pedro Madureira, Rui Manuel Ferreira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes
published pages: e0125494, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0125494
PLOS ONE 10/4 2019-10-08

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