ASTROCLOCK

Astrocyte regulation of circadian behavior

 Coordinatore FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

 Organization address address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
Titolo: Mr.
Nome: Gabriele
Cognome: Ballero
Email: send email
Telefono: +39 01071781716

 Nazionalità Coordinatore Italy [IT]
 Totale costo 241˙567 €
 EC contributo 241˙567 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-05-01   -   2016-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

 Organization address address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
Titolo: Mr.
Nome: Gabriele
Cognome: Ballero
Email: send email
Telefono: +39 01071781716

IT (GENOVA) coordinator 241˙567.60

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behavioral    mammals    brain    molecular    rhythmicity    cells    signaling    cycle    human    clock    disorders    behavior    circadian    astrocytes   

 Obiettivo del progetto (Objective)

'The human brain contains more than 100 billion cells, the majority being non-excitable glial cells, remarkably coordinated by an intrinsic clock that produce a circadian rhythm in their physiology and behavior. Circadian alterations affect human performances, productivity and are associated to increased risk of human-error related accidents and to a variety of brain disorders (e.g. sleep disorders). However, neuropharmacological R&D faces the lack of knowledge on how this clock signaling is hierarchically orchestrated within so many brain cells to lead to the cycle-to-cycle precision of circadian rhythmicity.

Recent studies suggest that astrocytes (the most abundant cells of the brain) actively participate in the modulation of physiological and circadian behavioral processes in invertebrates. Although astrocytes are directly involved in the regulation of synaptic neuronal signaling (“tripartite synapse”), the role of astrocytes in controlling circadian behavior in mammals is largely unknown.

This projects converges an original multidisciplinary research program, spanning the fields of molecular neurobiology, neuroelectronics and circadian biology, to unravel the molecular and functional mechanisms by which neurons and astrocytes cooperate to influence circadian rhythmicity in mammals. To do so, innovative genetics, molecular profiling (deep sequencing), behavioral, imaging and electrophysiological approaches will be used. The results of this proposal will lead to a deeper understanding on circadian rhythms in the brain and to the potential identification of new cellular and signaling targets for neuropharmacology.'

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