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Magnetic HEART SIGNED

Targeting the Human Myocardial Remodeling Process Using Novel Magnetic Force-Based Human Heart Tissue

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 Magnetic HEART project word cloud

Explore the words cloud of the Magnetic HEART project. It provides you a very rough idea of what is the project "Magnetic HEART" about.

leads    society    localized    mnps    alternative    cardiac    greatest    practical    accumulated    basic    scar    nanoparticles    scaffold    diseases    therapy    synthesized    breakthrough    treat    fibroblasts    cardiomyocytes    age    labeled    area    insights    extensive    model    native    deaths    myocardial    fibrotic    110    physiological    lesions    responsible    monitoring    regeneration    restoring    progressive    innovative    fundamental    billion    platform    techniques    cardiovascular    remodeled    human    therapeutic    time    ecm    modern    comprising    cells    deeper    heart    dysfunction    extracellular    collective    magnetic    reveal    remodeling    dimensional    raman    free    diagnosis    death    monitored    healthcare    translated    body    health    reported    3d    damaged    matrix    outcome    live    proportion    people    structure    marks    firsts    external    infarction    world    generation    pathological    treatment    first    spectroscopy    magnetically    function    previously    tissue    label    designed    vital    biochemical    biologically   

Project "Magnetic HEART" data sheet

The following table provides information about the project.

Coordinator		 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.imperial.ac.uk/people/limor.zd
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Cardiovascular diseases are responsible for the greatest proportion of deaths in people under the age of 70 and cost the EU €110 billion each year. A major cause of heart dysfunction following myocardial infarction is the extensive remodeling of the extracellular matrix (ECM), which leads to the formation of fibrotic scar and death of cardiomyocytes - a collective process known as myocardial remodeling. Diagnosis and treatment of this progressive pathological remodeling process are a top priority in modern healthcare. The project aims to develop novel 3-dimensional (3D) human Magnetic HEART tissue based on unique magnetic nanoparticles (MNPs), and includes two world firsts: (1) a model for long-term live monitoring of ECM remodeling and (2) a new generation of scaffold-free myocardial regeneration techniques. Innovative MNPs will be designed and synthesized to target and specifically label human cardiomyocytes and human cardiac fibroblasts. By applying an external magnetic field, the magnetically labeled heart cells will be accumulated to produce 3D human cardiac tissue, comprising its own biologically-produced ECM, which will offer a practical alternative to native human heart tissue. For the first time, live biochemical changes in cardiac ECM during physiological and pathological remodeling will be monitored using state-of-the-art Raman spectroscopy, which can reveal fundamental insights and improve the basic understanding of this process. This platform, which has not previously been reported, can be translated to treat the remodeled area in the heart by restoring structure and function to the damaged heart tissue, and marks a major breakthrough in magnetic targeting therapy for lesions localized deeper in the body. The outcome of this research has the potential to impact health and society and become a vital component in therapeutic approaches to cardiovascular diseases.

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The information about "MAGNETIC HEART" are provided by the European Opendata Portal: CORDIS opendata.

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