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PREDATOR SIGNED

Revealing the cell biology of a predatory bacterium in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PREDATOR project word cloud

Explore the words cloud of the PREDATOR project. It provides you a very rough idea of what is the project "PREDATOR" about.

bacterium    initiates    live    bdellovibrio    mechanistic    gram    odd    hunt    partitioned    contribution    polyploid    polarize    periplasmic    remarkable    prey    combination    revived    attracting    standards    unraveling    stability    textbook    periplasm    uncover    bacterial    cycle    daughter    entry    biological    cells    strains    niche    grows    feeds    model    space    filament    biology    antibiotic    molecular    largely    cell    tackle    predator    micro    predation    division    lifestyle    stands    despite    pathogens    shed    antibiotics    influence    quantitative    vivo    question    fascinating    innovative    genetic    negative    envelope    osmotic    copied    questions    thrives    liberated    remained    inside    discover    digests    unexplored    releasing    successful    living    imaging    predatory    fight    mechanisms    resistant    bacteria    host    progeny    mysterious    light    lack    models    species    canonical    event    single    developmental    exquisite    infection    genetics    bacteriovorus    pathogenic    binary   

Project "PREDATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙688 €
 EC max contribution 1˙499˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙499˙688.00

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 Project objective

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious.

My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

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The information about "PREDATOR" are provided by the European Opendata Portal: CORDIS opendata.

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