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PREDATOR SIGNED

Revealing the cell biology of a predatory bacterium in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PREDATOR project word cloud

Explore the words cloud of the PREDATOR project. It provides you a very rough idea of what is the project "PREDATOR" about.

question    infection    antibiotics    antibiotic    predation    inside    tackle    innovative    cell    entry    fight    standards    models    resistant    canonical    partitioned    polyploid    hunt    cycle    imaging    stands    progeny    contribution    quantitative    space    influence    single    prey    mechanisms    unexplored    pathogenic    living    vivo    bacteria    questions    grows    filament    binary    envelope    stability    bdellovibrio    genetics    host    fascinating    periplasmic    attracting    division    digests    gram    biological    cells    event    mechanistic    bacterium    uncover    revived    daughter    developmental    bacterial    liberated    combination    species    genetic    pathogens    unraveling    remarkable    successful    biology    odd    bacteriovorus    model    osmotic    thrives    largely    predator    releasing    strains    despite    initiates    periplasm    discover    lifestyle    mysterious    micro    lack    feeds    exquisite    copied    molecular    remained    textbook    shed    negative    live    niche    polarize    predatory    light   

Project "PREDATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙688 €
 EC max contribution 1˙499˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙499˙688.00

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 Project objective

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious.

My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

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