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FLOURISH SIGNED

IdentiFication of brain deveLopmental gene co-expression netwOrks to Understand RIsk for SchizopHrenia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "FLOURISH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO 

Organization address
address: PIAZZA UMBERTO I 1
city: BARI
postcode: 70121
website: www.uniba.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 262˙269 €
 EC max contribution 262˙269 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-11-08   to  2021-11-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) coordinator 262˙269.00
2    Lieber Institute for Brain Development US (Baltimore) partner 0.00

Map

 Project objective

Schizophrenia risk is largely determined by genetic variation and is associated with altered development of several brain regions. Since there are likely thousands of genetic risk variants, the biology of risk and its effects on neural development cannot be determined by examining one gene at a time. Rather, it is important to understand how these genes converge into molecular pathways that determine overall risk. Genes converge into pathways because they are coordinated in response to environmental and physiologic factors. Hence, FLOURISH aims to identify biologically plausible pathways of convergence of genetic risk for schizophrenia along neural development in critical brain regions involved in schizophrenia risk. Gene Co-expression Network Analysis is effective to identify pathways of genes that are regulated, and thus expressed, together. FLOURISH will study how gene co-expression unfolds along the lifespan in the prefrontal cortex, hippocampus and striatum. Gene co-expression networks will then be associated with genetic variants to identify markers of pathway co-regulation. Genetic markers of pathways co-regulation will be combined into polygenic scores that will be tested as predictors of the structure and activity of the target brain regions assessed by magnetic resonance imaging. The action will consist of a training period (2 years) which Dr. Giulio Pergola will spend at the Lieber Institute for Brain Development (LIBD) at Johns Hopkins University, Baltimore, USA. LIBD is unique because of the unrivalled technology, expertise and research data regarding brain development. Dr. Pergola will be training about RNA analyses and return to the University of Bari Aldo Moro (UNIBA) in the final year, to validate his genetic discoveries by means of neuroimaging. UNIBA is currently setting up the largest neuroimaging center in southern Italy and plans to have Dr. Pergola build an imaging genomics team to promote personalized medicine in psychiatry.

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The information about "FLOURISH" are provided by the European Opendata Portal: CORDIS opendata.

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