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EcoBox SIGNED

Ecosystem in a box: Dissecting the dynamics of a defined microbial community in vitro

Total Cost €

EC-Contrib. €

Partnership

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EcoBox project word cloud

Explore the words cloud of the EcoBox project. It provides you a very rough idea of what is the project "EcoBox" about.

encode vitro variability evolutionary immigration monitor hampered extend alternative gut sampled keystone mathematical models validating species parallel community interpretation predict interplay bacteria structure comparatively cultivation transform microbial stable human experimentally shaped ease view look densely interactions intrinsic optimized influenced validate first random therapeutic quantify drive manipulation assembled supply time model obtaining discern insights purposes vary genomes microorganisms setting metabolism automated external nutrient environment replicates series dynamics systematically resolved difficulty events members communities

Project "EcoBox" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	1˙493˙899 €
EC max contribution	1˙493˙899 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	1˙493˙899.00

Map

Project objective

The dynamics of microbial communities may be driven by the interactions between community members, controlled by the environment, shaped by immigration or random events, influenced by evolutionary processes or result from an interplay of all these factors. This project aims to improve our understanding of how community structure and the environment impact community dynamics. Towards this aim, a defined in vitro community of human gut bacteria will be assembled, since their genomes are available and their metabolism is comparatively well resolved. In the first step, we will quantify the intrinsic variability of community dynamics and look for alternative stable states. Next, we will systematically vary community structure as well as nutrient supply and monitor their effects on the dynamics. Finally, we will measure model parameters, evaluate to what extent different community models predict observed community dynamics and validate the models by identifying and experimentally validating keystone species. Studies of microbial community dynamics are hampered by the cost of obtaining densely sampled time series in replicates and by the difficulty of community manipulation. We will address these challenges by setting up an in vitro system for parallel and automated cultivation in well-controlled conditions and by working with defined communities, where every community member is known. The proposed project will discern how external factors and community structure drive community dynamics and encode this knowledge in mathematical models. Moreover, the project has the potential to transform our view on alternative microbial communities and their interpretation. In addition, the project will extend our knowledge of human gut microorganisms and their interactions. These insights will ease the design of defined gut communities optimized for therapeutic purposes.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2019-07-23 16:52:23

Take a look to the deliverables list in detail: detailed list of EcoBox deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Lisa RÃ¶ttjers, Karoline Faust manta: a Clustering Algorithm for Weighted Ecological Networks published pages: , ISSN: 2379-5077, DOI: 10.1128/msystems.00903-19	mSystems 5/1	2020-04-24
2019	Gino Vrancken, Ann C. Gregory, Geert R. B. Huys, Karoline Faust, Jeroen Raes Synthetic ecology of the human gut microbiota published pages: 754-763, ISSN: 1740-1526, DOI: 10.1038/s41579-019-0264-8	Nature Reviews Microbiology 17/12	2020-04-24

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The information about "ECOBOX" are provided by the European Opendata Portal: CORDIS opendata.