Opendata, web and dolomites

PARAMIR SIGNED

Investigating micro-RNA Dynamics using Paramagnetic NMR Spectroscopy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PARAMIR project word cloud

Explore the words cloud of the PARAMIR project. It provides you a very rough idea of what is the project "PARAMIR" about.

biophysical    fundamental    discovery    accurate    opening    md    goals    micro    first    last    structural    rna    profoundly    play    applicable    rnas    molecular    silent    diversity    preparation    yield    oriented    conceptual    strategies    function    bottleneck    characterization    fluctuations    rational    dynamical    sparsity    bioengineering    framework    fascinating    otherwise    capturing    chemically    nuclear    innovative    models    overcome    substrate    conformational    landscape    nmr    drug    gene    decode    coding    differentiation    details    60    paramagnetic    analytical    triggered    genes    cell    biochemical    humans    measureable    proliferation    leap    unprecedented    dynamics    combining    spectroscopy    broadly    experiments    experimental    discoveries    protein    establishing    respect    bases    revealed    simulations    conception    introduce    extremely    preventing    precise    class    functions    acquire    strategic    description    biology    positions    resonance    molecules    decades    atomic    data    barrier    magnetic    silencing    avenues    tags    oncogenesis    mirna    modifying    computational    dynamic    suited    over    turn    small    discovered    functional    roles   

Project "PARAMIR" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙633˙500 €
 EC max contribution 1˙633˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙633˙500.00

Map

 Project objective

Over the last decades, new discoveries have revealed an ever-increasing diversity of RNA functions, profoundly modifying the conceptual framework of molecular biology. This is the case of micro-RNAs (miRNA), a fascinating class of small non-coding RNA that play essential roles in RNA induced gene silencing and are estimated to target up to 60% of protein-coding genes in humans. RNA functional diversity is often triggered by conformational changes, so capturing the dynamics of these molecules is key to a precise understanding of their function, which in turn is essential to control their activity. Nuclear Magnetic Resonance (NMR) spectroscopy is extremely well suited to investigate dynamical processes. However, the sparsity of measureable NMR data in a RNA sample represents a major bottleneck, preventing so far an accurate description of RNA conformational fluctuations. This project aims to overcome this barrier by developing paramagnetic NMR for RNA. By chemically modifying an RNA, I will introduce paramagnetic tags to strategic positions so as to acquire NMR data from otherwise silent substrate. Adequate computational and analytical models will be developed to decode the experimental data into an atomic-level description of dynamics. These goals require a leap forward with respect to today’s approaches. I propose to achieve this by combining innovative sample preparation strategies and NMR experiments, high magnetic fields, and MD simulations. With these methods, I will enable the determination of the dynamic landscape of let-7, the first miRNA discovered in humans, involved in cell proliferation and differentiation and oncogenesis. This project will yield a broadly applicable method for the structural and dynamic characterization of RNA with unprecedented details. This knowledge will improve our fundamental biochemical and biophysical conception of RNA, opening new avenues for bioengineering and establishing the bases for rational RNA-oriented drug discovery.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PARAMIR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PARAMIR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOCELFATE (2019)

Evolution of cell fate specification modes in spiral cleavage

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More