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N-STRAINED SIGNED

Nitrogen-Radical-Based Radical Strain-Release Strategies for the Divergent Assembly of Polyfunctionalized 3D-Building Blocks

Total Cost €

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EC-Contrib. €

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Partnership

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 N-STRAINED project word cloud

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molecules    strain    divergent    potency    limited       strategies    shaped    strategic    construction    substantially    building    prepared    innovative    generating    discover    implications    structural    platform    small    hydrocarbons    medicinal    explore    introduce    agrochemicals    strained    compounds    underpin    eg    pentylamines    assemble    difficulties    explores    materials    quest    group    flat    replace    transferring    university    capitalizes    designing    reactivity    preparing    polyfunctionalized    lives    propellane    3d    reaction    facilitated    bioisoter    radicals    nitrogenated    pentyl    invention    direct    form    drugs    central    saturated    training    envisioned    host    clinical    release    bicyclo    manchester    disseminating    organic    generate    manipulate    2d    modifying    evolve    preparation    bonds    severely    valuable    synthetic    scientific    pharmaceutical    life    sharing    chemistry    containing    architectures    photoredox    space    react    ways    photocatalysis    basis    continuous    endeavour    chemical    introducing    almost    aromatics    career    disclosed    urgent    nitrogen    blocks    expand    motif    plan   

Project "N-STRAINED" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 212˙933.00

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 Project objective

Nitrogen-containing compounds underpin every aspect of our life: they form the structural basis of almost all drugs, agrochemicals and materials. The invention of methods to form C–N bonds is of strategic importance to discover and evolve molecules with direct implications on our lives. Central to this quest is designing synthetic strategies able to explore novel areas of chemical space. As the pharmaceutical sector is now aware of the greater clinical success of molecules with 3D architectures, developing methods able to assemble 3D-shaped and saturated building blocks is a topic of continuous scientific endeavour. The small and strained bicyclo[1.1.1]pentyl motif has been identified as a valuable bioisoter to replace flat (2D) aromatics and improve the potency of lead molecules. However, difficulties in preparing and modifying this structural element have severely limited its use in medicinal chemistry. There is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compounds. This project seeks to substantially expand the fields of photocatalysis and nitrogen-radicals by introducing the concept of “photoredox strain-release”: a novel reactivity that explores the ability of nitrogen-radicals to react with strained hydrocarbons (eg propellane) and enable a unique preparation of polyfunctionalized bicyclo[1.1.1]pentylamines. This research capitalizes on recent developments of the host group that has disclosed 2 novel ways to effectively generate nitrogen radicals. This reactivity will be integrated with other reaction platform allowing the divergent 1-step construction of many important nitrogenated 3D-building blocks that cannot be prepared by any other method. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

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