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N-STRAINED SIGNED

Nitrogen-Radical-Based Radical Strain-Release Strategies for the Divergent Assembly of Polyfunctionalized 3D-Building Blocks

Total Cost €

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EC-Contrib. €

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Partnership

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 N-STRAINED project word cloud

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manchester    clinical    direct    structural    saturated    lives    strategic    underpin    ways    quest    small    limited    synthetic    introducing    discover    generate    preparing    innovative    continuous    bonds    form    reactivity    space    reaction    scientific    3d    group    generating    blocks    severely    containing    modifying    nitrogenated    construction       sharing    pentylamines    implications    pentyl    react    assemble    nitrogen    invention    drugs    photocatalysis    radicals    transferring    almost    expand    strategies    release    pharmaceutical    building    life    organic    disclosed    compounds    molecules    disseminating    agrochemicals    university    medicinal    central    endeavour    chemical    eg    hydrocarbons    explore    evolve    plan    replace    facilitated    chemistry    photoredox    divergent    architectures    valuable    aromatics    capitalizes    flat    materials    substantially    bioisoter    basis    propellane    urgent    explores    strain    host    difficulties    designing    potency    strained    polyfunctionalized    preparation    career    2d    platform    shaped    manipulate    envisioned    prepared    bicyclo    motif    introduce    training   

Project "N-STRAINED" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 212˙933.00

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 Project objective

Nitrogen-containing compounds underpin every aspect of our life: they form the structural basis of almost all drugs, agrochemicals and materials. The invention of methods to form C–N bonds is of strategic importance to discover and evolve molecules with direct implications on our lives. Central to this quest is designing synthetic strategies able to explore novel areas of chemical space. As the pharmaceutical sector is now aware of the greater clinical success of molecules with 3D architectures, developing methods able to assemble 3D-shaped and saturated building blocks is a topic of continuous scientific endeavour. The small and strained bicyclo[1.1.1]pentyl motif has been identified as a valuable bioisoter to replace flat (2D) aromatics and improve the potency of lead molecules. However, difficulties in preparing and modifying this structural element have severely limited its use in medicinal chemistry. There is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compounds. This project seeks to substantially expand the fields of photocatalysis and nitrogen-radicals by introducing the concept of “photoredox strain-release”: a novel reactivity that explores the ability of nitrogen-radicals to react with strained hydrocarbons (eg propellane) and enable a unique preparation of polyfunctionalized bicyclo[1.1.1]pentylamines. This research capitalizes on recent developments of the host group that has disclosed 2 novel ways to effectively generate nitrogen radicals. This reactivity will be integrated with other reaction platform allowing the divergent 1-step construction of many important nitrogenated 3D-building blocks that cannot be prepared by any other method. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

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