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N-STRAINED SIGNED

Nitrogen-Radical-Based Radical Strain-Release Strategies for the Divergent Assembly of Polyfunctionalized 3D-Building Blocks

Total Cost €

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EC-Contrib. €

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Partnership

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 N-STRAINED project word cloud

Explore the words cloud of the N-STRAINED project. It provides you a very rough idea of what is the project "N-STRAINED" about.

nitrogen    underpin    strain    host    assemble    containing    expand    innovative    substantially    continuous    valuable    introducing    chemical    urgent    platform    3d    form    transferring    organic    motif    molecules    invention    react    life    structural    preparing    drugs    sharing    aromatics    direct    agrochemicals    disclosed    envisioned    difficulties    release    hydrocarbons    propellane    university    explores    bioisoter    potency    almost    space    bicyclo    bonds    2d    synthetic    nitrogenated    generating    reactivity    compounds    chemistry    severely    evolve    eg    pharmaceutical    photocatalysis    divergent    career    medicinal    basis    prepared    generate    strained    plan    discover    modifying    radicals    manchester    pentylamines    manipulate    architectures    materials    preparation    scientific    designing    capitalizes    facilitated    pentyl    introduce    limited    lives    strategies    group    replace    reaction    polyfunctionalized    disseminating    strategic    explore    photoredox    flat    saturated    shaped    building    clinical    training    1    implications    blocks    central    ways    small    construction    quest    endeavour   

Project "N-STRAINED" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

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# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 212˙933.00

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 Project objective

Nitrogen-containing compounds underpin every aspect of our life: they form the structural basis of almost all drugs, agrochemicals and materials. The invention of methods to form C–N bonds is of strategic importance to discover and evolve molecules with direct implications on our lives. Central to this quest is designing synthetic strategies able to explore novel areas of chemical space. As the pharmaceutical sector is now aware of the greater clinical success of molecules with 3D architectures, developing methods able to assemble 3D-shaped and saturated building blocks is a topic of continuous scientific endeavour. The small and strained bicyclo[1.1.1]pentyl motif has been identified as a valuable bioisoter to replace flat (2D) aromatics and improve the potency of lead molecules. However, difficulties in preparing and modifying this structural element have severely limited its use in medicinal chemistry. There is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compounds. This project seeks to substantially expand the fields of photocatalysis and nitrogen-radicals by introducing the concept of “photoredox strain-release”: a novel reactivity that explores the ability of nitrogen-radicals to react with strained hydrocarbons (eg propellane) and enable a unique preparation of polyfunctionalized bicyclo[1.1.1]pentylamines. This research capitalizes on recent developments of the host group that has disclosed 2 novel ways to effectively generate nitrogen radicals. This reactivity will be integrated with other reaction platform allowing the divergent 1-step construction of many important nitrogenated 3D-building blocks that cannot be prepared by any other method. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

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