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CONNECT SIGNED

Connecting neural networks: Nervous-system-on-Chip Technology

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CONNECT" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 6˙807˙867 €
 EC max contribution 6˙807˙867 € (100%)
 Programme 1. H2020-EU.1.2.2. (FET Proactive)
 Code Call H2020-FETPROACT-2018-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 1˙675˙000.00
2    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 1˙247˙005.00
3    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 1˙010˙307.00
4    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 953˙125.00
5    AALTO KORKEAKOULUSAATIO SR FI (ESPOO) participant 903˙680.00
6    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 842˙500.00
7    FFUND BV NL (AMSTERDAM) participant 176˙250.00

Map

 Project objective

Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model in Parkinson’s Disease. This provides CONNECT with novel insights, thereby paving the way for future development of therapeutic strategies.

 Publications

year authors and title journal last update
List of publications.
2019 Bastiaens, Xie, Luttge
Nanogroove-Enhanced Hydrogel Scaffolds for 3D Neuronal Cell Culture: An Easy Access Brain-on-Chip Model
published pages: 638, ISSN: 2072-666X, DOI: 10.3390/mi10100638
Micromachines 10/10 2020-02-05
2019 Alex Bastiaens, Jean-Philippe Frimat, Teun van Nunen, Regina Luttge
Exploiting nanogroove-induced cell culture anisotropy to advance in vitro brain models
published pages: 61802, ISSN: 2166-2754, DOI: 10.1116/1.5119687
Journal of Vacuum Science & Technology B 37/6 2020-02-05

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The information about "CONNECT" are provided by the European Opendata Portal: CORDIS opendata.

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