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iProg

Tailored cell-based therapies for frontotemporal dementia and related genetically defined CNS orphan indications

Total Cost €

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EC-Contrib. €

0

Partnership

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 iProg project word cloud

Explore the words cloud of the iProg project. It provides you a very rough idea of what is the project "iProg" about.

proprietary    right    tech    efficacious    progranulin    levels    brain    instrument    patients    therapy    lower    detect    biotherapeutics    sinfonia    severe    reaching    modifying    safe    prepare    exposure    company    situ    lay    candidates    transforming    phasei    disorders    ultimately    desired    treatment    clinical    frontotemporal    signals    device    vision    iia    innovation    brd    safety    diseases    driver    iprog    systemic    neurotrophic    negligible    locally    neurodegenerative    causative    manner    successful    ftd    genetically    populations    biologics    first    overcome    combat    changers    solutions    therapeutic    entirely    paving    medical    gene    efficacy    repair    sme    unmet    framework    cns    implantable    standards    drug    patient    frame    leverage    thereby    disease    mutations    suffer    restores    lives    biotechnology    pgrn    orphan    market    degeneration    game    failing    indications    explore    ing    generation    medicine    conduct    therapies   

Project "iProg" data sheet

The following table provides information about the project.

Coordinator
SINFONIA BIOTHERAPEUTICS AB 

Organization address
address: HALSOVAGEN 7, NOVUM
city: HUDDINGE
postcode: 141 57
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.sinfoniabiotherapeutics.com/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SINFONIA BIOTHERAPEUTICS AB SE (HUDDINGE) coordinator 50˙000.00

Map

 Project objective

Sinfonia Biotherapeutics is a high-tech biotechnology company. Our vision is to become a main driver in technology innovation for CNS medicine, where we lay the frame-work for entirely novel therapeutic concepts and solutions that combat the unmet medical need of severe CNS conditions, ultimately transforming patient lives. We are developing targeted therapies for genetically defined CNS orphan indications that are built on a proprietary medical device – the Brain Repair Device - that overcome several of the existing challenges associated with the failing clinical development of drug candidates for neurodegenerative diseases today. The BRD is an implantable device that allows for the in situ production of our therapeutic biologics resulting in desired CNS exposure, while the systemic exposure of the therapeutic factor is negligible. We are developing a new generation of tailored biologics for genetically defined disease/patient populations that target the disease locally in the brain. With our therapies we are thus reaching the right patient, with the right treatment, in an efficacious and safe manner. Through the SME Instrument, we will focus on further developing iProg, a novel neurotrophic therapy that restores progranulin levels in the brain of patients that suffer from frontotemporal degeneration due to mutations in the PGRN gene (FTD/PGRN), which results in lower progranulin production and is disease-causative. We will use the SME Instrument funding (Phase 1&2) to prepare and conduct PhaseI/IIa studies to explore the safety and detect the first signals of efficacy of iProg. If successful, the project will set new standards on the biologics for neurodegenerative disease market, paving a way to growth and new potential partnerships for Sinfonia. Our disease-modifying therapies have the potential to leverage an important framework for therapeutic development in neurodegenerative disorders in general and thereby to become real game changers in CNS medicine.

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The information about "IPROG" are provided by the European Opendata Portal: CORDIS opendata.

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