EU H2020 Project "EVERBONE (Mechano-activated Extracellular Vesicle Based Repair of Bone)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/219001/index.html

EVERBONE project word cloud

Explore the words cloud of the EVERBONE project. It provides you a very rough idea of what is the project "EVERBONE" about.

osteocyte standard commercial angiogenically ip regeneration vitro defects building healing mechanical osteoporosis medicinal yield applicants treatment procedure maev morbidity activated recruiting endogenous multitargeted leverage mechanically person every crisis ed mimics therapeutics mortality mechanobiology multifaceted plateaus extracellular limitations resorptive overcome suffers performed clinical reducing months discovery vesicles primed severe annually treatments economic catabolic angiogenesis maevs conditioning healthcare preclinical model endothelial purely anti fracture bioreactor preventative burden generate mobilise physical create populations localize cells health commercialise ing mediate financial evaluation 36billion anabolic transform stem regrowth patient rates risk forming beneficial exercise osteogenesis seconds commercialisation osteogenically whereby everbone secondly bone cell

Project "EVERBONE" data sheet

The following table provides information about the project.

Coordinator	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	149˙891 €
EC max contribution	149˙891 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2020-06-30

#	participants	country	role	EC contrib. [€]
1	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN	IE (DUBLIN)	coordinator	149˙891.00

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

IE (DUBLIN)

coordinator

149˙891.00

Project objective

Every 30 seconds a person suffers an osteoporosis-related bone fracture in Europe, resulting in significant morbidity, mortality and healthcare costs estimated at €36billion annually. Current anti-catabolic therapeutics are associated with severe side effects and are purely preventative, while the only anabolic treatment plateaus at 6 months. This has resulted in a crisis in osteoporosis treatment. Therefore, the aim of EVERBONE is to develop and commercialise a new anabolic multitargeted medicinal product for bone regeneration that mimics the beneficial effects of physical exercise, by recruiting endogenous cells to promote angiogenesis, osteogenesis and bone formation. Building on the discovery that osteocyte-derived mechanically activated extracellular vesicles (MAEVs) mediate the anabolic bone forming response to physical exercise, this project will develop novel bioreactor systems to increase MAEV yield in vitro and scale up for clinical use. Secondly, it will identify a standard mechanical conditioning procedure to generate optimised angiogenically and osteogenically primed MAEVs. Finally, preclinical evaluation of MAEV treatment will be performed in a model of osteoporosis and bone healing, whereby it is expected that MAEVs will localize to bone and mobilise endogenous endothelial and stem cell populations to enhance bone regeneration in osteoporosis and improved healing rates in bone defects. This regrowth of bone will overcome current limitations of anti-resorptive treatments, reducing the risk of fracture and thus the financial burden of treatment. The project will leverage the applicants experience in bone mechanobiology to develop a new product with significant commercial potential. Therefore, the impact of EVERBONE will be multifaceted: it will transform how osteoporosis is treated, it will create economic value through the commercialisation of IP, and most importantly it will improve patient experience and their long-term health and well-being.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVERBONE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVERBONE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)