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EVERBONE SIGNED

Mechano-activated Extracellular Vesicle Based Repair of Bone

Total Cost €

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EC-Contrib. €

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Partnership

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 EVERBONE project word cloud

Explore the words cloud of the EVERBONE project. It provides you a very rough idea of what is the project "EVERBONE" about.

maevs    stem    evaluation    crisis    preventative    yield    commercialise    vitro    health    multifaceted    leverage    osteoporosis    beneficial    treatment    angiogenically    clinical    healthcare    ing    activated    risk    mechanical    regrowth    financial    populations    morbidity    every    resorptive    osteogenically    anti    therapeutics    fracture    standard    36billion    commercialisation    person    annually    seconds    preclinical    healing    severe    physical    ip    osteogenesis    cells    plateaus    multitargeted    regeneration    primed    suffers    mortality    building    model    performed    medicinal    burden    create    mechanically    localize    reducing    bone    transform    overcome    mechanobiology    forming    mediate    applicants    extracellular    secondly    vesicles    discovery    anabolic    ed    months    treatments    catabolic    bioreactor    limitations    cell    procedure    purely    mobilise    commercial    rates    angiogenesis    whereby    maev    conditioning    economic    endogenous    everbone    defects    patient    endothelial    osteocyte    recruiting    generate    exercise    mimics   

Project "EVERBONE" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 149˙891 €
 EC max contribution 149˙891 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 149˙891.00

Map

 Project objective

Every 30 seconds a person suffers an osteoporosis-related bone fracture in Europe, resulting in significant morbidity, mortality and healthcare costs estimated at €36billion annually. Current anti-catabolic therapeutics are associated with severe side effects and are purely preventative, while the only anabolic treatment plateaus at 6 months. This has resulted in a crisis in osteoporosis treatment. Therefore, the aim of EVERBONE is to develop and commercialise a new anabolic multitargeted medicinal product for bone regeneration that mimics the beneficial effects of physical exercise, by recruiting endogenous cells to promote angiogenesis, osteogenesis and bone formation. Building on the discovery that osteocyte-derived mechanically activated extracellular vesicles (MAEVs) mediate the anabolic bone forming response to physical exercise, this project will develop novel bioreactor systems to increase MAEV yield in vitro and scale up for clinical use. Secondly, it will identify a standard mechanical conditioning procedure to generate optimised angiogenically and osteogenically primed MAEVs. Finally, preclinical evaluation of MAEV treatment will be performed in a model of osteoporosis and bone healing, whereby it is expected that MAEVs will localize to bone and mobilise endogenous endothelial and stem cell populations to enhance bone regeneration in osteoporosis and improved healing rates in bone defects. This regrowth of bone will overcome current limitations of anti-resorptive treatments, reducing the risk of fracture and thus the financial burden of treatment. The project will leverage the applicants experience in bone mechanobiology to develop a new product with significant commercial potential. Therefore, the impact of EVERBONE will be multifaceted: it will transform how osteoporosis is treated, it will create economic value through the commercialisation of IP, and most importantly it will improve patient experience and their long-term health and well-being.

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The information about "EVERBONE" are provided by the European Opendata Portal: CORDIS opendata.

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