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EVERBONE SIGNED

Mechano-activated Extracellular Vesicle Based Repair of Bone

Total Cost €

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EC-Contrib. €

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Partnership

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 EVERBONE project word cloud

Explore the words cloud of the EVERBONE project. It provides you a very rough idea of what is the project "EVERBONE" about.

multitargeted    model    financial    resorptive    treatments    standard    stem    bioreactor    preventative    maev    burden    angiogenesis    mimics    commercialise    secondly    risk    treatment    catabolic    mobilise    defects    economic    conditioning    endothelial    osteogenesis    regeneration    preclinical    osteoporosis    every    procedure    physical    healthcare    populations    yield    building    primed    clinical    localize    annually    rates    vitro    whereby    reducing    mechanically    generate    recruiting    person    health    mediate    bone    severe    ed    maevs    patient    osteogenically    osteocyte    anti    angiogenically    crisis    cell    discovery    mortality    performed    beneficial    plateaus    months    healing    seconds    transform    suffers    regrowth    anabolic    purely    mechanobiology    everbone    mechanical    therapeutics    create    applicants    overcome    morbidity    forming    vesicles    multifaceted    medicinal    leverage    extracellular    commercial    evaluation    ing    cells    activated    exercise    fracture    commercialisation    endogenous    limitations    36billion    ip   

Project "EVERBONE" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 149˙891 €
 EC max contribution 149˙891 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 149˙891.00

Map

 Project objective

Every 30 seconds a person suffers an osteoporosis-related bone fracture in Europe, resulting in significant morbidity, mortality and healthcare costs estimated at €36billion annually. Current anti-catabolic therapeutics are associated with severe side effects and are purely preventative, while the only anabolic treatment plateaus at 6 months. This has resulted in a crisis in osteoporosis treatment. Therefore, the aim of EVERBONE is to develop and commercialise a new anabolic multitargeted medicinal product for bone regeneration that mimics the beneficial effects of physical exercise, by recruiting endogenous cells to promote angiogenesis, osteogenesis and bone formation. Building on the discovery that osteocyte-derived mechanically activated extracellular vesicles (MAEVs) mediate the anabolic bone forming response to physical exercise, this project will develop novel bioreactor systems to increase MAEV yield in vitro and scale up for clinical use. Secondly, it will identify a standard mechanical conditioning procedure to generate optimised angiogenically and osteogenically primed MAEVs. Finally, preclinical evaluation of MAEV treatment will be performed in a model of osteoporosis and bone healing, whereby it is expected that MAEVs will localize to bone and mobilise endogenous endothelial and stem cell populations to enhance bone regeneration in osteoporosis and improved healing rates in bone defects. This regrowth of bone will overcome current limitations of anti-resorptive treatments, reducing the risk of fracture and thus the financial burden of treatment. The project will leverage the applicants experience in bone mechanobiology to develop a new product with significant commercial potential. Therefore, the impact of EVERBONE will be multifaceted: it will transform how osteoporosis is treated, it will create economic value through the commercialisation of IP, and most importantly it will improve patient experience and their long-term health and well-being.

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The information about "EVERBONE" are provided by the European Opendata Portal: CORDIS opendata.

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