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ATHENA SIGNED

Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "ATHENA" data sheet

The following table provides information about the project.

Coordinator
BRUNEL UNIVERSITY LONDON 

Organization address
address: KINGSTON LANE
city: UXBRIDGE
postcode: UB8 3PH
website: www.brunel.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 6˙565˙463 €
 EC max contribution 6˙565˙463 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BRUNEL UNIVERSITY LONDON UK (UXBRIDGE) coordinator 1˙052˙313.00
2    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 1˙071˙857.00
3    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 997˙330.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 778˙372.00
5    STICHTING VU NL (AMSTERDAM) participant 698˙130.00
6    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 652˙917.00
7    WATCHFROG FR (EVRY) participant 576˙505.00
8    RISE RESEARCH INSTITUTES OF SWEDEN AB SE (BORAS) participant 530˙245.00
9    OREBRO UNIVERSITY SE (OREBRO) participant 157˙255.00
10    KARLSTADS UNIVERSITET SE (KARLSTAD) participant 50˙537.00

Map

 Project objective

The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing.

 Deliverables

List of deliverables.
Project website Websites, patent fillings, videos etc. 2020-04-21 01:01:02

Take a look to the deliverables list in detail:  detailed list of ATHENA deliverables.

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The information about "ATHENA" are provided by the European Opendata Portal: CORDIS opendata.

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