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Andrea SIGNED

A Novel Detection protocols for REliable prostate cancer Assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "Andrea" data sheet

The following table provides information about the project.

Coordinator
CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED 

Organization address
address: DUBRAVSKA CESTA 9
city: BRATISLAVA
postcode: 845
website: www.chem.sk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Slovakia [SK]
 Total cost 149˙499 €
 EC max contribution 149˙499 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED SK (BRATISLAVA) coordinator 87˙500.00
2    GLYCANOSTICS SRO SK (BRATISLAVA) participant 61˙999.00

Map

 Project objective

The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercialisation of the PCa diagnostics kit. Pre-clinical (60 human serum samples) is ongoing and retrospective validation study (450 human serum samples) of the assay will be performed by statistical analysis using a receiver operating characteristic (ROC) curve. The PoC describes all steps, which have been developed so far and all necessary steps, which need to be done for retrospective validation study, product development and commercialisation through our newly incorporated start-up Glycanostics Ltd. (www.glycanostics.com). We will provide PCa diagnostic test resulting in a second opinion to guide the right decision if the biopsy is needed. This will avoid the needless and unreliable biopsies and in the future rival an inaccurate PSA testing.

 Publications

year authors and title journal last update
List of publications.
2019 Tomas Bertok, Lenka Lorencova, Stefania Hroncekova, Veronika Gajdosova, Eduard Jane, Michal Hires, Peter Kasak, Ondrej Kaman, Roman Sokol, Vladimir Bella, Anita Andicsova Eckstein, Jaroslav Mosnacek, Alica Vikartovska, Jan Tkac
Synthesis and characterization of Au nanoshells with a magnetic core and betaine derivatives
published pages: 1999-2012, ISSN: 2215-0161, DOI: 10.1016/j.mex.2019.08.017
MethodsX 6 2019-12-16
2019 Jan Tkac, Veronika Gajdosova, Stefania Hroncekova, Tomas Bertok, Michal Hires, Eduard Jane, Lenka Lorencova, Peter Kasak
Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer
published pages: 20180077, ISSN: 2042-8898, DOI: 10.1098/rsfs.2018.0077
Interface Focus 9/2 2019-12-16
2019 Tomas Bertok, Lenka Lorencova, Stefania Hroncekova, Veronika Gajdosova, Eduard Jane, Michal Hires, Peter Kasak, Ondrej Kaman, Roman Sokol, Vladimir Bella, Anita Andicsova Eckstein, Jaroslav Mosnacek, Alica Vikartovska, Jan Tkac
Advanced impedimetric biosensor configuration and assay protocol for glycoprofiling of a prostate oncomarker using Au nanoshells with a magnetic core
published pages: 24-29, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.01.052
Biosensors and Bioelectronics 131 2019-12-16
2018 Jan Tkac, Tomas Bertok, Michal Hires, Eduard Jane, Lenka Lorencova, Peter Kasak
Glycomics of prostate cancer: updates
published pages: 65-76, ISSN: 1478-9450, DOI: 10.1080/14789450.2019.1549993
Expert Review of Proteomics 16/1 2019-12-16

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