Opendata, web and dolomites

OBERON SIGNED

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "OBERON" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 6˙745˙894 €
 EC max contribution 5˙978˙762 € (89%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙900˙553.00
2    ARISTOTELIO PANEPISTIMIO THESSALONIKIS EL (THESSALONIKI) participant 793˙725.00
3    ENVE.X SINGLE MEMBER PC EL (THESALONIKI) participant 610˙000.00
4    INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS FR (VERNEUIL EN HALATTE) participant 558˙945.00
5    FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ES (BARCELONA) participant 550˙366.00
6    INSERM TRANSFERT SA FR (PARIS) participant 379˙750.00
7    Masarykova univerzita CZ (BRNO STRED) participant 330˙407.00
8    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI IT (MILANO) participant 304˙000.00
9    UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE ES (ELCHE) participant 259˙706.00
10    BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY CZ (Brno) participant 215˙250.00
11    AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL FR (MAISONS ALFORT) participant 76˙058.00
12    METABOLOMIC DISCOVERIES GMBH DE (POTSDAM) participant 0.00

Map

 Project objective

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "OBERON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "OBERON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

DECISION (2020)

DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Read More  

ESPACE (2020)

Human Cell Atlas of the Pancreas

Read More  

miniNO (2020)

Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Read More