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NUMA-SCALE

Enabling Large-Scale GMP-ready Peptide Production with a new, reliable and cost-efficient Bioprocess

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NUMA-SCALE project word cloud

Explore the words cloud of the NUMA-SCALE project. It provides you a very rough idea of what is the project "NUMA-SCALE" about.

german 14 tackle human positive upstream pharmaceutical approved numa bad 8m compromises mission drugs insulin biomolecules gained alternatives numaswitch gmp scalability 15 companies good innovative boost scalable manufacture gt business economical raw 2015 tech successfully extend therapeutics downstream revenues foot safe jobs peptides ready patented diseases certain sugar treating transfer company numatag manufacturing creation material market metabolism commercial carbon founded 2023 generate ip technologies length environmentally practices ton markets compliant ones peptide seize efficiency 90 block numaferm contract competent employability facilities print limitation massive efficient selective amounts escalate 50x relatively venture efficacious tolerated upscale

Project "NUMA-SCALE" data sheet

The following table provides information about the project.

Coordinator	NUMAFERM GMBH Organization address address: MEROWINGERPLATZ 1A city: DUSSELDORF postcode: 40225 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://numaferm.com/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2018
Duration (year-month-day)	from 2018-11-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NUMAFERM GMBH NUMAFERM GMBH Organization address address: MEROWINGERPLATZ 1A city: DUSSELDORF postcode: 40225 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	coordinator	50˙000.00

Map

Project objective

Peptides, competent biomolecules, have gained increased interest as innovative therapeutics in the pharmaceutical market due to being highly selective, efficacious, relatively safe and well tolerated. Peptide-based drugs have been successfully applied in treating certain human diseases. Well-known example includes insulin, which compromises a peptide that is built to block and control the metabolism of sugar. With the increase of approved peptide-based drugs, the production of peptides will escalate. Yet, peptide manufacture companies (for peptide-based drugs), which need to be compliant with good manufacturing practices (GMP), face a several challenges, the main ones being high production costs on downstream processes (due to the use of high raw material amounts) and bad scalability. Numaferm is a German company founded in 2015 with the mission of making peptides economical for pharmaceutical markets. To tackle current challenges, we have developed two (patented) innovative technologies (NUMAtag and NUMAswitch) whose unique features are not offered by the alternatives in the market for peptide manufacture: cost-efficient production (50x reduction of manufacturing costs, under GMP); environmentally friendly process (reduced carbon foot print by >90%); scalable production (peptide scalability by ton scale with no peptide length limitation), thus enabling a high efficiency upstream and downstream process for peptide manufacture. Through the NUMA-SCALE project we aim to upscale our production and extend our commercial capabilities (by making our processes ready for tech-transfer into GMP facilities of Contract Manufacture Organizations) thus allowing us to seize more business opportunities. This project will have a massive positive impact to Numaferm – will boost our revenues (€14.8M by 2023), employability (creation of 15 new jobs) and generate new IP, allowing us to continuously venture new markets with our technology.

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The information about "NUMA-SCALE" are provided by the European Opendata Portal: CORDIS opendata.