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LeukemiaEnviron SIGNED


Total Cost €


EC-Contrib. €






 LeukemiaEnviron project word cloud

Explore the words cloud of the LeukemiaEnviron project. It provides you a very rough idea of what is the project "LeukemiaEnviron" about.

implication    interaction    constantly    niches    immune    engraftment    transplantable    responsible    model    survival    frequent    regulator    data    therapeutically    pro    cd40    transferable    signalling    12    mechanisms    pdx    nfkb    lymphocytic    circulate    inhibited    therapies    mir    peripheral    malignancies    cll    inhibitors    proteins    re    therapeutic    complicates    leukemia    proliferation    utilized    node    figure    course    regulation    signaling    integrate    lymph    influences    print    therapy    proliferative    animal    adults    acts    29    vs    mirnas    led    cd20    il4    dependency    primary    biology    bcr    blood    times    function    disease    obtain    cells    receptor    rituximab    nodes    stable    microenvironment    first    mouse    malignant    normal    signals    microenvironmental    activation    universal    hypothesize    interleukin    interactions    cell    unknown    samples    microenvironments    stream    chronic    mediated    propensity    finger    reveal    relevance    see   

Project "LeukemiaEnviron" data sheet

The following table provides information about the project.

Masarykova univerzita 

Organization address
address: Zerotinovo namesti 9
postcode: 60177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙499˙990 €
 EC max contribution 1˙499˙990 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Masarykova univerzita CZ (BRNO STRED) coordinator 1˙499˙990.00


 Project objective

B cell chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults. CLL cells are characterized by their universal dependency on pro-survival and pro-proliferative signals from immune niches. To achieve this they constantly re-circulate between blood and lymph nodes, which is inhibited by novel microenvironment-targeting therapies such as “BCR inhibitors”. We aim to reveal how the malignant B cells change the propensity of their signalling pathways in response to the different microenvironments such as peripheral blood vs lymph node to obtain the proliferative signals. This is of major relevance for CLL, but also transferable to the biology of some other B cell malignancies and/or normal B cells. We analyzed the “finger print” of microenvironmental interactions in many CLL samples at various times during the disease course or during therapy. The obtained data led us to hypothesize on the mechanisms of regulation of signalling propensity of two pathways that are responsible for proliferation and survival of CLL cells, namely B Cell Receptor (BCR) signalling and signals from T-cells mediated by CD40/IL4. In aim 1 we hypothesize that CD20 is one of the key proteins involved in CLL cell activation, and influences BCR and interleukin signalling (see figure). This has important therapeutic implication since CD20 is used as a therapeutic target for 20 years (rituximab), but its function in CLL/normal B cells is unknown. In aim 2 we hypothesize that miR-29 acts a key regulator of T-cell signalling from CD40 and down-stream NFkB activation (see figure). This represents the first example of miRNAs‘ role in the propensity of T-cell interaction, and could be also utilized therapeutically. In aim 3 we will integrate our data on microenvironmental signaling (aim 12) and develop a first mouse model for PDX that would allow stable engraftment of primary CLL cells. Currently, CLL is non-transplantable to any animal model which complicates studies of its biology.

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The information about "LEUKEMIAENVIRON" are provided by the European Opendata Portal: CORDIS opendata.

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