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SMA-TB SIGNED

A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

Total Cost €

EC-Contrib. €

Partnership

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SMA-TB project word cloud

Explore the words cloud of the SMA-TB project. It provides you a very rough idea of what is the project "SMA-TB" about.

length decrease predicting thanks differ add pathogen mathematical science outcomes health tb anti therapy tissue hyperinflammation integrating personalize damage directed disease effect relevance infectious threatening costly stratifying world intervention bad protocol clinically benefit potentially resistance medical infective stratify hdt ds forms clinical life poses generate medicine cure ct personalized susceptibility validate stages aspirin highest faster tremendous mdr resistant drug risk therapies predict regimen biomarkers generating severity trials tuberculosis shorten individualized treatment sequelae data patients standard sensitive responsible lung chronic host prevalence therapeutic worse reduce inflammatory strain region permanent course adjunct algorithm network sma physicians

Project "SMA-TB" data sheet

The following table provides information about the project.

Coordinator	INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Organization address address: CTRA DE CANYET S/N city: BADALONA BARCELONA postcode: 8916 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	6˙388˙104 €
EC max contribution	6˙388˙104 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Organization address address: CTRA DE CANYET S/N city: BADALONA BARCELONA postcode: 8916 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BADALONA BARCELONA)	coordinator	1˙632˙750.00
2	WITS HEALTH CONSORTIUM (PTY) LTD WITS HEALTH CONSORTIUM (PTY) LTD Organization address address: Princess of Wales Terrace, Parktown, 31 city: Johannesburg postcode: 2193 website: www.witshealth.co.za contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZA (Johannesburg)	participant	1˙107˙324.00
3	OSLO UNIVERSITETSSYKEHUS HF OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	840˙125.00
4	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	656˙910.00
5	NATIONAL CENTER FOR TUBERCULOSIS AND LUNG DISEASES JSC NATIONAL CENTER FOR TUBERCULOSIS AND LUNG DISEASES JSC Organization address address: 8 ADJARA city: TBILISI postcode: 101 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	GE (TBILISI)	participant	646˙016.00
6	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	612˙563.00
7	ANAXOMICS BIOTECH SL ANAXOMICS BIOTECH SL Organization address address: CALLE DIPUTACIO 237, P 1 PTA 1 city: BARCELONA postcode: 8007 website: www.anaxomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	428˙250.00
8	TES2A EUROPE CONSULTING AND BUSINESS DEVELOPMENT SL TES2A EUROPE CONSULTING AND BUSINESS DEVELOPMENT SL Organization address address: RBLA LLUIS COMPANYS 18 (3,1) city: SANT QUIRZE DEL VALLES postcode: 8192 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANT QUIRZE DEL VALLES)	participant	339˙260.00
9	LIONEX GMBH LIONEX GMBH Organization address address: Salzdahlumer Strasse 196 city: BRAUNSCHWEIG postcode: 38126 website: www.lionex.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	124˙905.00

Map

Project objective

Tuberculosis (TB) is a chronic, life-threatening infectious disease which poses a tremendous challenge for physicians, researchers and Health Systems, which treatment is long, based only on the drug susceptibility of the responsible infective strain and very costly in drug-resistant cases (MDR-TB). The European Region still has the highest prevalence of MDR-TB in the world. Host-Directed Therapies (HDT) have been recently proposed to shorten treatment length and by to improve the patients’ outcomes while not increasing the risk of generating drug resistance. As hyperinflammation is responsible of the lung damage associated to patients’ worse outcomes and sequelae, one of the approaches is to add an HDT with anti-inflammatory effect to the current drug regimen to cure the patients faster while having less permanent lung damage. Because TB has a wide range of clinical forms and severity stages, any therapeutic regimen needs to be studied in clinical trials (CT) as its benefit might differ among patients. No individualized personalized medicine is possible without stratifying the patients by integrating pathogen and host factors that will predict the course of the disease and the response to the intervention. SMA-TB objectives are: • To evaluate in a CT the potential impact of aspirin (an anti-inflammatory HDT) as adjunct to standard therapy for drug sensitive (DS-) and MDR-TB. This potentially will reduce tissue damage, decrease the length of the treatment and the risk of bad outcomes. • To identify and clinically validate host and pathogen biomarkers for further selection according to their relevance in terms of their ability to predict TB course and outcomes and response to treatment thanks to data science protocol. • To generate a medical algorithm to stratify patients using network-based mathematical modelling for predicting the course of the disease and its response to the intervention, to be applied during clinical management to improve and personalize TB

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