#	Pagina
attuale pagina	/open-h2020/projects/219825/index.html

Opendata, web and dolomites

ERGO SIGNED

Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

Total Cost €

EC-Contrib. €

Partnership

Views

ERGO project word cloud

Explore the words cloud of the ERGO project. It provides you a very rough idea of what is the project "ERGO" about.

faster health regulation biomarkers effect validate pituitary fish regulations successful data foundation gonadal responsive disrupting suitable outcome environmental breaking identification wall beneficial extrapolation tgs mechanisms axes retinoid vertebrate tests hpg versa tdc cheaper paradigm tool receptor safer guidelines tg class free biotransformation aop hazard ergo proof simpler vivo outcomes silico thyroid industry adverse mammalian endpoints mammals humans network edcs extrapolate strategy plausible human oecd inclusion edc hypothalamus endocrine amphibian predictive chemicals battery classes regulatory cross scientifically regulators conserved shift safety assays connecting td standardized rxr vitro axis vice iata lower modeling risk

Project "ERGO" data sheet

The following table provides information about the project.

Coordinator	SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	6˙998˙388 €
EC max contribution	5˙992˙437 € (86%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	coordinator	1˙273˙185.00
2	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	695˙665.00
3	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	610˙065.00
4	ECOLE NORMALE SUPERIEURE DE LYON ECOLE NORMALE SUPERIEURE DE LYON Organization address address: PARVIS RENE DESCARTES 15 city: LYON postcode: 69342 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	534˙875.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	468˙040.00
6	HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ Organization address address: PERMOSERSTRASSE 15 city: LEIPZIG postcode: 4318 website: www.ufz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEIPZIG)	participant	450˙000.00
7	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	417˙875.00
8	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	411˙120.00
9	FORSCHUNGSVERBUND BERLIN EV FORSCHUNGSVERBUND BERLIN EV Organization address address: RUDOWER CHAUSSEE 17 city: BERLIN postcode: 12489 website: www.fv-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	410˙500.00
10	AquaTT UETP Ltd AquaTT UETP Ltd Organization address address: PLEASANTS STREET OLYMPIC HOUSE UNIT 8 SECOND FLOOR city: DUBLIN postcode: 8 website: www.aquatt.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	324˙875.00
11	UMWELTBUNDESAMT UMWELTBUNDESAMT Organization address address: Woerlitzer Platz 1 city: DESSAU-ROSSLAU postcode: 6844 website: www.uba.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DESSAU-ROSSLAU)	participant	206˙675.00
12	PETER MATTHIESSEN PETER MATTHIESSEN Organization address address: DOLFAN BARN BEULAH city: LLANWRTYD WELLS postcode: LD5 4UE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LLANWRTYD WELLS)	participant	104˙249.00
13	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	participant	85˙312.00
14	Dow AgroSciences LLC Dow AgroSciences LLC Organization address address: Zionsville Road 9330 city: INDIANAPOLIS postcode: 46268-1054 website: www.dowagro.com/homepage/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (INDIANAPOLIS)	participant	0.00
15	L'OREAL SA L'OREAL SA Organization address address: 14 RUE ROYALE city: PARIS postcode: 75008 website: www.loreal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00
16	PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY Organization address address: 22-2 SETO KANAZAWA-KU city: YOKOHAMA postcode: 236 0027 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (YOKOHAMA)	participant	0.00

Map

Project objective

ERGO presents a new approach that will support a paradigm shift in the regulatory use of standardized test guidelines (TGs) by breaking the existing wall between mammalian and non-mammalian vertebrate testing and assessment of endocrine disrupting chemicals (EDCs). The highly conserved thyroid system will be used as the “proof of concept”, but also other conserved endocrine axes/systems such as the Retinoid X Receptor (RXR) and the Hypothalamus Pituitary Gonadal (HPG) axis can be adapted to the cross-vertebrate class approach. ERGO will investigate a battery of draft in vitro assays and evaluate thyroid-responsive biomarkers and endpoints (B/E) suitable for extrapolation of effects from fish and amphibian tests to humans and other mammals (and vice versa) and finally validate successful B/E for inclusion in existing in vivo or new in vitro OECD TGs. A cross-class adverse outcome pathway (AOP) network will provide the scientifically plausible and evidence-based foundation for the selection of B/E in lower vertebrate assays predictive of human health outcomes. In silico modeling and biotransformation data will support cross-vertebrate class effect extrapolation. Major outcomes of ERGO will be: 1) New thyroid-related B/E for inclusion in OECD TGs for improved identification of TDC. 2) An Integrated Approach to Testing and Assessment (IATA) of chemicals for TD based on a multi-class vertebrate AOP network connecting endocrine mechanisms in one vertebrate class to adverse outcomes in another class for safer regulation of EDCs. 3) A tool for TG end users, such as regulators and industry, to extrapolate thyroid effects between vertebrate classes. Implementation of the ERGO IATA strategy in regulations of EDC will make hazard and risk assessment faster, cheaper, simpler and safer and support industry in the development of EDC-free products beneficial for environmental and human safety.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ERGO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ERGO" are provided by the European Opendata Portal: CORDIS opendata.