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LEGACy SIGNED

CeLac and European consortium for a personalized medicine approach to Gastric Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 LEGACy project word cloud

Explore the words cloud of the LEGACy project. It provides you a very rough idea of what is the project "LEGACy" about.

poorly    ebv    secondary    intervention    total    legacy    celac    vary    genetic    omics    levels    barr    location    patients    international    epidemiology    histological    women    public    men    susceptibility    standpoint    worldwide       24    treatments    10    rates    infection    prevention    mortality    gcs    positive    personalized    plays    primary    contrast    sexes    molecular    gastric    cancer    deaths    similarly    globally    locally    urgent    health    eastern    makeup    model    lowest    helicobacter    integrative    participating    disease    epidemiological    south    northern    epstein    arrival    dietary    asia    medicine    virus    conceptual    biology    tumour    strategy    stage    strains    incidence    pylori    differences    death    asian    america    largely    outcomes    respectively    723    multicentre    multiple    strategies    prognosis    highest    revolutionized    bacterium    extended    sharp    populations    genome    none    databases    gc    central    countries   

Project "LEGACy" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA 

Organization address
address: AV MENENDEZ PELAYO 4
city: VALENCIA
postcode: 46010
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙993˙056 €
 EC max contribution 3˙577˙431 € (90%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA ES (VALENCIA) coordinator 638˙315.00
2    IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP PT (PORTO) participant 660˙162.00
3    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON ES (BARCELONA) participant 550˙000.00
4    STICHTING VUMC NL (AMSTERDAM) participant 471˙875.00
5    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE CL (SANTIAGO) participant 305˙235.00
6    ANAXOMICS BIOTECH, S.L. ES (BARCELONA) participant 275˙218.00
7    CABALLERO LLANO CARMELO CESAR PY (ASUNCION) participant 216˙093.00
8    EUROPEAN CANCER PATIENT COALITION BE (BRUXELLES) participant 197˙750.00
9    ALEXANDER FLEMING SA AR (BUENOS AIRES) participant 131˙625.00
10    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 131˙156.00
11    Instituto Nacional de Cancerología MX (MEXICO) participant 0.00

Map

 Project objective

Globally, gastric cancer (GC) is the third leading cause of cancer death in both sexes worldwide (723,000 deaths, 8.8% of the total). The highest estimated mortality rates are in Eastern Asia (24 per 100,000 in men, 9.8 per 100,000 in women), the lowest in Northern America (2.8 and 1.5, respectively). High mortality rates are also present in both sexes in Central and Eastern Europe, and in Central and South America. None strategies have improved prognosis in locally advanced stage III and IV GC. Therefore, an urgent intervention is needed. Epidemiological and molecular features of GCs can vary widely according to their histological type, location and genetic makeup of the tumour. The reasons behind these differences are multiple and complex and may include genetic susceptibility, strains of the bacterium Helicobacter pylori (H. pylori) and dietary factors. In particular, H. pylori infection plays a relevant role in GC incidence. Similarly, about 10% of GC patients are positive for the infection of the Epstein Barr Virus (EBV) . Most studies and current international databases on late-stage/advanced GC are largely based on Asian populations, in sharp contrast tumour biology and genome of EU and CELAC countries is poorly known. From a public health standpoint, prevention can be conducted at three levels: primary, secondary, and for improving outcomes at the advanced stage of disease. In recent years, the arrival of personalized medicine has revolutionized available treatments for cancer patients. The primary aim of LEGACY project is to improve GC outcomes by applying personalized medicine at the three levels of prevention: in EU and CELAC countries participating in this multicentre case-control study based on an “omics integrative epidemiology” conceptual model as a strategy to be extended worldwide.

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The information about "LEGACY" are provided by the European Opendata Portal: CORDIS opendata.

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