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PREMSTEM SIGNED

Brain injury in the premature born infant: stem cell regeneration research network

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PREMSTEM" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 10˙708˙285 €
 EC max contribution 8˙999˙620 € (84%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙748˙075.00
2    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 1˙313˙000.00
3    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 1˙213˙105.00
4    CHIESI FARMACEUTICI SPA IT (Parma) participant 930˙000.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 653˙068.00
6    ICONEUS FR (ANTONY) participant 577˙250.00
7    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 570˙125.00
8    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 486˙397.00
9    ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY SPAIN SL ES (BARCELONA) participant 395˙605.00
10    INSERM TRANSFERT SA FR (PARIS) participant 324˙562.00
11    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 322˙000.00
12    UNIVERSITE DE GENEVE CH (GENEVE) participant 290˙931.00
13    EUROPEAN FOUNDATION FOR THE CARE OF NEWBORN INFANTS DE (MUNCHEN) participant 175˙500.00
14    CEREBRAL PALSY ALLIANCE AU (SYDNEY) participant 0.00
15    ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY*RMIT UNIVERSITY AU (MELBOURNE) participant 0.00

Map

 Project objective

This project will provide new knowledge regarding the best regimen, timing, dose, and route of administration of human mesenchymal stem cells (H-MSC) for regenerating the brain damage in infants born preterm; born before 37 of a typical 40 weeks of gestation. Over 15 million babies are born preterm every year it is a leading cause of death and permanent disability, often due to brain damage. The H-MSC that we will comprehensively screen are FDA-approved and in the process of being produced in a GMP grade, making them suitable for future clinical trials in human preterm born infants. These H-MSC will be evaluated in a large number of rodent models mimicking the key insults and brain damage observed in human preterm infants who will develop later motor, cognitive, and behavioral deficits. We will also apply theseH-MSC in two sheep models of injury relevant to brain damage associated with preterm birth. These large animal trials are a key step before initiating clinical trials in this high risk human population. Additional Workpackages will address the mechanisms underlying the regenerative effects of these H-MSC. This project addresses the call text by value adding to current knowledge of stem cell types and applying it to a large patient group with an unmet clinical need – infants with encephalopathy of the preterm born infant. Steps on the innovation chain targeted – preclinical research, proof of concept and to a lesser degree characterization of regenerative mechanisms.

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The information about "PREMSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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