Explore the words cloud of the PREMSTEM project. It provides you a very rough idea of what is the project "PREMSTEM" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||10˙708˙285 €|
|EC max contribution||8˙999˙620 € (84%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2020-01-01 to 2024-12-31|
Take a look of project's partnership.
|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||1˙748˙075.00|
|2||UNIVERSITEIT MAASTRICHT||NL (MAASTRICHT)||participant||1˙313˙000.00|
|3||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||participant||1˙213˙105.00|
|4||CHIESI FARMACEUTICI SPA||IT (Parma)||participant||930˙000.00|
|5||GOETEBORGS UNIVERSITET||SE (GOETEBORG)||participant||653˙068.00|
|7||UNIVERSITAETSKLINIKUM ESSEN||DE (ESSEN)||participant||570˙125.00|
|8||CONSIGLIO NAZIONALE DELLE RICERCHE||IT (ROMA)||participant||486˙397.00|
|9||ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY SPAIN SL||ES (BARCELONA)||participant||395˙605.00|
|10||INSERM TRANSFERT SA||FR (PARIS)||participant||324˙562.00|
|11||STICHTING KATHOLIEKE UNIVERSITEIT||NL (NIJMEGEN)||participant||322˙000.00|
|12||UNIVERSITE DE GENEVE||CH (GENEVE)||participant||290˙931.00|
|13||EUROPEAN FOUNDATION FOR THE CARE OF NEWBORN INFANTS||DE (MUNCHEN)||participant||175˙500.00|
|14||CEREBRAL PALSY ALLIANCE||AU (SYDNEY)||participant||0.00|
|15||ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY*RMIT UNIVERSITY||AU (MELBOURNE)||participant||0.00|
This project will provide new knowledge regarding the best regimen, timing, dose, and route of administration of human mesenchymal stem cells (H-MSC) for regenerating the brain damage in infants born preterm; born before 37 of a typical 40 weeks of gestation. Over 15 million babies are born preterm every year it is a leading cause of death and permanent disability, often due to brain damage. The H-MSC that we will comprehensively screen are FDA-approved and in the process of being produced in a GMP grade, making them suitable for future clinical trials in human preterm born infants. These H-MSC will be evaluated in a large number of rodent models mimicking the key insults and brain damage observed in human preterm infants who will develop later motor, cognitive, and behavioral deficits. We will also apply theseH-MSC in two sheep models of injury relevant to brain damage associated with preterm birth. These large animal trials are a key step before initiating clinical trials in this high risk human population. Additional Workpackages will address the mechanisms underlying the regenerative effects of these H-MSC. This project addresses the call text by value adding to current knowledge of stem cell types and applying it to a large patient group with an unmet clinical need – infants with encephalopathy of the preterm born infant. Steps on the innovation chain targeted – preclinical research, proof of concept and to a lesser degree characterization of regenerative mechanisms.
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The information about "PREMSTEM" are provided by the European Opendata Portal: CORDIS opendata.
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