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FutureTrophicFactors SIGNED

Elucidating therapeutic effects and mode of action of future trophic factorsin ALS and Parkinson’s disease

Total Cost €

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EC-Contrib. €

0

Partnership

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 FutureTrophicFactors project word cloud

Explore the words cloud of the FutureTrophicFactors project. It provides you a very rough idea of what is the project "FutureTrophicFactors" about.

protects    trophic    peripheral    treating    culture    blood    neurotrophic    da    regulate    clinical    bbb    progression    human    subcutaneously    innovative    proteins    survival    ultimate    treat    cultures    drawbacks    neurodegenerative    trials    prevalence    motor    aging    groundbreaking    discovery    amyotrophic    peptides    action    toxin    relieve    stop    cell    lateral    ips    polypeptides    function    cdnf    mode    understand    pd    expectancy    cells    stem    invasive    direct    ohda    therapeutic    surgery    treatment    measured    difficulty    explored    enters    monkey    dopamine    als    treatments    vitro    branching    model    sclerosis    life    population    symptoms    penetrating    overcome    protein    effect    variant    rodent    models    restores    pluripotent    brain    administered    urgent    animal    data    efficacy    parkinson    rhesus    fragment    showed    patients    diseases    secretary    barrier    ntfs    poor    pass    drugs    therapies    neurorestorative    neurons    nerve    despite    neurite    disease    ntf    vivo   

Project "FutureTrophicFactors" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙497˙597 €
 EC max contribution 1˙497˙597 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙497˙597.00

Map

 Project objective

The prevalence of neurodegenerative diseases such as Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is growing rapidly due to an aging population and increased life expectancy. Current treatments for ALS and PD only relieve symptoms and cannot stop the progression of the disease, thus there is an urgent need for new therapies. Neurotrophic factors (NTFs) are secretary proteins that regulate the survival of neurons, neurite growth and branching. They have been explored as novel drugs for the treatment of ALS and PD but their efficacy in clinical trials is poor. CDNF is a protein with NTF properties that protects and restores the function of dopamine neurons in rodent and rhesus monkey toxin models of PD more effectively than other NTFs. CDNF is currently in phase 1/2 clinical trials on PD patients. Despite promising results with CDNF in animal models of PD, NTF and CDNF-based treatments have drawbacks. CDNF requires direct delivery to the brain through invasive surgery since, it cannot pass through the blood brain barrier (BBB). My recent discovery, however, may overcome this difficulty: I showed that a novel CDNF variant protects DA neurons in vitro and in vivo and that it efficiently enters DA neurons in culture. Furthermore, my data show the CDNF fragment can pass through the BBB as measured by 3 different methods and has a neurorestorative effect in a 6-OHDA toxin model of PD when administered subcutaneously. The ultimate goal of my research is to understand the mode of action and therapeutic effect of novel BBB penetrating CDNF-derived polypeptides in cultures of human induced pluripotent stem (iPS) cell-derived nerve cells from patients and in animal models of ALS and PD. The innovative aspect of this proposal is the new groundbreaking concept for treating neurodegenerative diseases – peripheral delivery of BBB penetrating peptides with trophic factor properties and the potential to treat non-motor and motor symptoms in ALS and PD patients.

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The information about "FUTURETROPHICFACTORS" are provided by the European Opendata Portal: CORDIS opendata.

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