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GLADIATOR SIGNED

Next-generation theranostics of brain pathologies with autonomous externally controllable nanonetworks: a trans-disciplinary approach with bio-nanodevice interfaces

Total Cost €

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EC-Contrib. €

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Partnership

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 GLADIATOR project word cloud

Explore the words cloud of the GLADIATOR project. It provides you a very rough idea of what is the project "GLADIATOR" about.

discipline    societal    inscs    spatiotemporal    wireless    engineered    components    cancer    release    generate    bio    tumours    electronic    detrimental    cells    complete    autonomous    socioeconomic    first    multiforme    communications    fluorescent    anticipated    oncology    shift    stem    burgeoning    conceptual    cellular    molecular    designed    underlying    recurrence    stimulation    diagnostics    building    rationally    nanomachines    sub    nanonetworks    breakthrough    malignancies    platform    delivering    prototype    consisting    sciences    supra    emergence    hybrid    glioblastoma    interfering    brain    insc    ict    establishes    coupled    optoelectronic    cell    ecmc    exosomal    organoids    nanomachine    reprogramming    industry    network    faceted    neural    things    therapeuticdiagnostic    radiofrequency    grim    radical    autologous    ushering    framework    engineering    vanguard    theranostic    biological    host    evolution    micro    despite    prognosis    gladiator    environment    monitor    mirnas    appropriate    interventions    promises    implantable    vision    transforming    therapeutic    channels    paradigm    communication    therapy    pathologies    solution    bridging    external    intervention    autonomously    disorders    sensors    nano    interface    revolutionary    renewal    proof    clinically    life    demand    time    externally    drastic    progress    internet    nanonetwork    nanotechnology    tumour    applicable   

Project "GLADIATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 6˙122˙255 €
 EC max contribution 5˙982˙255 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 953˙125.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 1˙758˙103.00
3    E.P.O.S. IASIS RESEARCH AND DEVELOPMENT LTD CY (LEFKOSIA) participant 1˙111˙540.00
4    OULUN YLIOPISTO FI (OULU) participant 950˙535.00
5    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) participant 787˙076.00
6    WATERFORD INSTITUTE OF TECHNOLOGY IE (Waterford) participant 421˙875.00
7    OSAKA UNIVERSITY JP (OSAKA) participant 0.00

Map

 Project objective

Brain pathologies are highly complex disorders. Despite recent progress, their prognosis is grim, defining a high societal challenge. Bridging life sciences, bio-nanotechnology, engineering and ICT, GLADIATOR promises a vanguard and comprehensive theranostic (therapeuticdiagnostic) solution for brain malignancies. Through a multi-faceted breakthrough, GLADIATOR will provide, for the first time, a working prototype of a complete, autonomous and clinically applicable, nanonetwork-based, Molecular Communications system based on the conceptual framework of Externally Controllable Molecular Communications (ECMC). Using Glioblastoma Multiforme tumours, the most detrimental brain pathologies, as a proof-of-concept case, GLADIATOR will implement a platform of cell-based and electronic components. Implantable autologous organoids of engineered neural stem cells (iNSCs) will release rationally designed exosomal bio-nanomachines, delivering reprogramming (therapeutic) miRNAs and building nanonetworks. Interfering with the underlying biological environment, the nanonetworks will define a revolutionary intervention. A hybrid bio-electronic interface, consisting of coupled external and implantable devices, will enable communication channels with host-derived fluorescent bio-nanomachines via micro-optoelectronic sensors. The cellular, sub-cellular and electronic components will be integrated into a wireless ECMC network. This system will autonomously monitor the spatiotemporal tumour evolution and recurrence and generate, on demand, appropriate reprogramming interventions, by radiofrequency stimulation of iNSC renewal. A paradigm shift in Oncology Research is anticipated via the supra-discipline of “bio-nanomachine diagnostics”. GLADIATOR establishes a radical long-term vision leading to a drastic change in cancer therapy, also ushering the emergence of the ECMC field and transforming the burgeoning industry of Internet of Nano-bio-things, with high socioeconomic impact.

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