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GLADIATOR SIGNED

Next-generation theranostics of brain pathologies with autonomous externally controllable nanonetworks: a trans-disciplinary approach with bio-nanodevice interfaces

Total Cost €

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EC-Contrib. €

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Partnership

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GLADIATOR project word cloud

Explore the words cloud of the GLADIATOR project. It provides you a very rough idea of what is the project "GLADIATOR" about.

inscs delivering interface theranostic consisting solution industry wireless things therapy sciences discipline establishes nanonetworks nanomachine cancer ecmc hybrid gladiator stem autologous evolution generate stimulation coupled grim components interventions time radiofrequency nanonetwork cells communications nano malignancies autonomously burgeoning electronic first revolutionary spatiotemporal multiforme renewal nanotechnology drastic appropriate faceted channels pathologies interfering complete vanguard diagnostics rationally socioeconomic ict communication organoids proof breakthrough bridging exosomal fluorescent life external oncology conceptual anticipated sensors shift designed supra cell platform autonomous engineering biological cellular recurrence ushering underlying release progress micro optoelectronic paradigm building disorders molecular prototype mirnas intervention societal framework transforming therapeutic therapeuticdiagnostic host emergence neural tumour demand nanomachines vision tumours environment bio insc sub engineered externally despite monitor implantable internet promises radical clinically prognosis reprogramming applicable network glioblastoma detrimental brain

Project "GLADIATOR" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF CYPRUS Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 website: www.ucy.ac.cy contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Cyprus [CY]
Total cost	6˙122˙255 €
EC max contribution	5˙982˙255 € (98%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF CYPRUS UNIVERSITY OF CYPRUS Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 website: www.ucy.ac.cy contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CY (NICOSIA)	coordinator	953˙125.00
2	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	1˙758˙103.00
3	E.P.O.S. IASIS RESEARCH AND DEVELOPMENT LTD E.P.O.S. IASIS RESEARCH AND DEVELOPMENT LTD Organization address address: KOSTI PALAMA 34 ASPELIA DIAM 5 city: LEFKOSIA postcode: 1096 website: http://www.epos-iasis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CY (LEFKOSIA)	participant	1˙111˙540.00
4	OULUN YLIOPISTO OULUN YLIOPISTO Organization address address: PENTTI KAITERAN KATU 1 city: OULU postcode: 90014 website: www.oulu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULU)	participant	950˙535.00
5	NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 website: www.ntnu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	787˙076.00
6	WATERFORD INSTITUTE OF TECHNOLOGY WATERFORD INSTITUTE OF TECHNOLOGY Organization address address: CORK ROAD city: Waterford postcode: X91 website: http://cefims.eu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Waterford)	participant	421˙875.00
7	OSAKA UNIVERSITY OSAKA UNIVERSITY Organization address address: 1-1 Yamadaoka Suita city: OSAKA postcode: 565-0871 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (OSAKA)	participant	0.00

Map

Project objective

Brain pathologies are highly complex disorders. Despite recent progress, their prognosis is grim, defining a high societal challenge. Bridging life sciences, bio-nanotechnology, engineering and ICT, GLADIATOR promises a vanguard and comprehensive theranostic (therapeuticdiagnostic) solution for brain malignancies. Through a multi-faceted breakthrough, GLADIATOR will provide, for the first time, a working prototype of a complete, autonomous and clinically applicable, nanonetwork-based, Molecular Communications system based on the conceptual framework of Externally Controllable Molecular Communications (ECMC). Using Glioblastoma Multiforme tumours, the most detrimental brain pathologies, as a proof-of-concept case, GLADIATOR will implement a platform of cell-based and electronic components. Implantable autologous organoids of engineered neural stem cells (iNSCs) will release rationally designed exosomal bio-nanomachines, delivering reprogramming (therapeutic) miRNAs and building nanonetworks. Interfering with the underlying biological environment, the nanonetworks will define a revolutionary intervention. A hybrid bio-electronic interface, consisting of coupled external and implantable devices, will enable communication channels with host-derived fluorescent bio-nanomachines via micro-optoelectronic sensors. The cellular, sub-cellular and electronic components will be integrated into a wireless ECMC network. This system will autonomously monitor the spatiotemporal tumour evolution and recurrence and generate, on demand, appropriate reprogramming interventions, by radiofrequency stimulation of iNSC renewal. A paradigm shift in Oncology Research is anticipated via the supra-discipline of “bio-nanomachine diagnostics”. GLADIATOR establishes a radical long-term vision leading to a drastic change in cancer therapy, also ushering the emergence of the ECMC field and transforming the burgeoning industry of Internet of Nano-bio-things, with high socioeconomic impact.

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