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HOTZYMES SIGNED

Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation

Total Cost €

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EC-Contrib. €

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Partnership

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HOTZYMES project word cloud

Explore the words cloud of the HOTZYMES project. It provides you a very rough idea of what is the project "HOTZYMES" about.

kinetics diffusion scales physical bioprocesses biomolecules schemes break gradients free fabricate fundamental heating enzyme changing biocommodities producing unprecedented precisely pharmaceuticals functional breakthrough spatio generation enzymatic alternating expertise technological game conjugating optimal disposable remotely breaking immobilized sequential cascades nanoparticles recyclable answer paradigm biotransformations ground meet materials unpaired biocatalysis pot regulated orchestrated hotzymes temporal separation perfectly re function industrial tuning integration exert bioreactors porous questions disciplines nanoscale scientific reactions govern efficient temperature concurrent coordinated unsatisfactory magnetic incompatible mechanisms conjugates microparticles spatial uncoordinated heat synthetic locally cell catalyzed transfer enzymes

Project "HOTZYMES" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	2˙992˙388 €
EC max contribution	2˙992˙388 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-04-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	810˙532.00
2	TECHNISCHE UNIVERSITAET GRAZ TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	503˙110.00
3	NANOSCALE BIOMAGNETICS SOCIEDAD LIMITADA NANOSCALE BIOMAGNETICS SOCIEDAD LIMITADA Organization address address: CALLE PANAMA 2, LOCAL 1 city: ZARAGOZA postcode: 50012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	participant	497˙000.00
4	FORSCHUNGSZENTRUM JULICH GMBH FORSCHUNGSZENTRUM JULICH GMBH Organization address address: WILHELM JOHNEN STRASSE city: JULICH postcode: 52428 website: www.fz-juelich.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JULICH)	participant	393˙821.00
5	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	participant	302˙510.00
6	UNIVERSITA DEGLI STUDI DELL'INSUBRIA UNIVERSITA DEGLI STUDI DELL'INSUBRIA Organization address address: VIA RAVASI 2 city: VARESE postcode: 21100 website: www.uninsubria.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VARESE)	participant	250˙000.00
7	ACIB GMBH ACIB GMBH Organization address address: KRENNGASSE 37/2 city: GRAZ postcode: 8010 website: www.acib.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	216˙237.00
8	UNIVERSIDAD DE ZARAGOZA UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	participant	19˙177.00

Map

Project objective

Enzymatic cascades open a path to the efficient implementation of complex biotransformations for producing from high-cost pharmaceuticals to low-cost biocommodities. However, for multi-step synthetic schemes catalyzed by incompatible or unpaired enzymatic cascades, efficient cell-free one-pot systems, where enzymes are perfectly orchestrated and regulated, have yet to be developed. In HOTZYMES, we propose to develop a new ground-breaking concept to exert functional control over different enzymes using magnetic heating. We expect to control enzyme activity by conjugating enzymes and magnetic nanoparticles and tuning temperature gradients at the nanoscale to precisely and locally reach the optimal temperature of each immobilized enzyme. This will allow an unprecedented spatio-temporal control over the kinetics of multi-enzymatic cascades by remotely applying alternating magnetic fields. To ensure an easy separation, re-utilization and integration into bioreactors, these conjugates will be integrated within porous microparticles. To meet this technological break-through we will need to design and fabricate a new generation of magnetic bioreactors specific to the field of Biocatalysis. We will need to answer fundamental questions about the physical mechanisms that govern heat transfer/diffusion between magnetic materials and biomolecules at different spatial scales by bringing together different scientific and technological disciplines and expertise. HOTZYMES will thus contribute to change current industrial biotransformations from an unsatisfactory current paradigm (uncoordinated enzyme function, sequential reactions, disposable bioprocesses) into a game-changing breakthrough (coordinated enzyme function, concurrent reactions, recyclable bioprocesses).

Publications

List of publications.
year	authors and title	journal	last update
2020	Patrizia Bonfanti, Anita Colombo, Melissa Saibene, Luisa Fiandra, Ilaria Armenia, Federica Gamberoni, Rosalba Gornati, Giovanni Bernardini, Paride Mantecca Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles published pages: 196-213, ISSN: 1743-5390, DOI: 10.1080/17435390.2019.1685695	Nanotoxicology 14/2	2020-04-15
2020	T. Asimakidou, A. Makridis, S. Veintemillas-Verdaguer, M.P. Morales, I. Kellartzis, M. Mitrakas, G. Vourlias, M. Angelakeris, K. Simeonidis Continuous production of magnetic iron oxide nanocrystals by oxidative precipitation published pages: 124593, ISSN: 1385-8947, DOI: 10.1016/j.cej.2020.124593	Chemical Engineering Journal 393	2020-04-15

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The information about "HOTZYMES" are provided by the European Opendata Portal: CORDIS opendata.

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