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HOTZYMES SIGNED

Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation

Total Cost €

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EC-Contrib. €

0

Partnership

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 HOTZYMES project word cloud

Explore the words cloud of the HOTZYMES project. It provides you a very rough idea of what is the project "HOTZYMES" about.

scientific    microparticles    free    breaking    scales    regulated    answer    tuning    function    govern    industrial    fundamental    pharmaceuticals    technological    biomolecules    nanoscale    uncoordinated    mechanisms    unsatisfactory    materials    biocommodities    integration    precisely    producing    ground    fabricate    magnetic    enzyme    synthetic    catalyzed    efficient    temperature    separation    heating    disposable    nanoparticles    biotransformations    hotzymes    disciplines    incompatible    remotely    spatial    concurrent    locally    conjugating    coordinated    bioprocesses    unpaired    gradients    re    break    diffusion    recyclable    biocatalysis    paradigm    conjugates    heat    game    spatio    cell    transfer    functional    alternating    generation    unprecedented    questions    pot    schemes    exert    meet    bioreactors    orchestrated    enzymatic    cascades    porous    sequential    temporal    changing    immobilized    kinetics    perfectly    expertise    optimal    reactions    breakthrough    physical    enzymes   

Project "HOTZYMES" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙992˙388 €
 EC max contribution 2˙992˙388 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 810˙532.00
2    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) participant 503˙110.00
3    NANOSCALE BIOMAGNETICS SOCIEDAD LIMITADA ES (ZARAGOZA) participant 497˙000.00
4    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) participant 393˙821.00
5    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) participant 302˙510.00
6    UNIVERSITA DEGLI STUDI DELL'INSUBRIA IT (VARESE) participant 250˙000.00
7    ACIB GMBH AT (GRAZ) participant 216˙237.00
8    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) participant 19˙177.00

Map

 Project objective

Enzymatic cascades open a path to the efficient implementation of complex biotransformations for producing from high-cost pharmaceuticals to low-cost biocommodities. However, for multi-step synthetic schemes catalyzed by incompatible or unpaired enzymatic cascades, efficient cell-free one-pot systems, where enzymes are perfectly orchestrated and regulated, have yet to be developed. In HOTZYMES, we propose to develop a new ground-breaking concept to exert functional control over different enzymes using magnetic heating. We expect to control enzyme activity by conjugating enzymes and magnetic nanoparticles and tuning temperature gradients at the nanoscale to precisely and locally reach the optimal temperature of each immobilized enzyme. This will allow an unprecedented spatio-temporal control over the kinetics of multi-enzymatic cascades by remotely applying alternating magnetic fields. To ensure an easy separation, re-utilization and integration into bioreactors, these conjugates will be integrated within porous microparticles. To meet this technological break-through we will need to design and fabricate a new generation of magnetic bioreactors specific to the field of Biocatalysis. We will need to answer fundamental questions about the physical mechanisms that govern heat transfer/diffusion between magnetic materials and biomolecules at different spatial scales by bringing together different scientific and technological disciplines and expertise. HOTZYMES will thus contribute to change current industrial biotransformations from an unsatisfactory current paradigm (uncoordinated enzyme function, sequential reactions, disposable bioprocesses) into a game-changing breakthrough (coordinated enzyme function, concurrent reactions, recyclable bioprocesses).

 Publications

year authors and title journal last update
List of publications.
2020 Patrizia Bonfanti, Anita Colombo, Melissa Saibene, Luisa Fiandra, Ilaria Armenia, Federica Gamberoni, Rosalba Gornati, Giovanni Bernardini, Paride Mantecca
Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles
published pages: 196-213, ISSN: 1743-5390, DOI: 10.1080/17435390.2019.1685695
Nanotoxicology 14/2 2020-04-15
2020 T. Asimakidou, A. Makridis, S. Veintemillas-Verdaguer, M.P. Morales, I. Kellartzis, M. Mitrakas, G. Vourlias, M. Angelakeris, K. Simeonidis
Continuous production of magnetic iron oxide nanocrystals by oxidative precipitation
published pages: 124593, ISSN: 1385-8947, DOI: 10.1016/j.cej.2020.124593
Chemical Engineering Journal 393 2020-04-15

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