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LION-HEARTED SIGNED

Light and Organic Nanotechnology for Cardiovascular Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 LION-HEARTED project word cloud

Explore the words cloud of the LION-HEARTED project. It provides you a very rough idea of what is the project "LION-HEARTED" about.

treatment    blood    homing    optoceutic    proliferation    stimulating    synergistic    act    minimally    circulating    light    givers    phenotype    biocompatible    daily    aging    unprecedented    fate    limiting    disruption    life    semiconductors    survival    socio    patients    poor    ischemic    models    organic    rescue    modulating    negative    hurdles    invasive    insult    endothelial    worldwide    modulation    molecular    virtually    breakthrough    pharmaceutical    respect    cells    progression    lion    implantable    economical    mortality    function    gene    disorders    unfortunately    proof    optical    strategy    platform    huge    trigger    biological    cell    resolution    spatio    vivo    types    device    point    circumvent    lacking    lower    dependence    quality    vascularization    selectivity    pharmacological    consequence    invasiveness    electrical    cv    reverse    progenitors    temporal    reparative    urgently    therapies    resident    greatest    nanotechnology    cardiac    care    perfusion    systemic    realization    hf    phototransducers    restore    cardiovascular    combination    aneurysm    efficient    transplantation    incidence    morbidity    population    final    possibility    heart    disease    efficacy    outcome    preserve    repair    displays    animal    stenosis    least    stage    cardiomyocytes    hearted   

Project "LION-HEARTED" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙904˙413 €
 EC max contribution 2˙904˙413 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 509˙458.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 489˙730.00
3    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 450˙000.00
4    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 313˙475.00
5    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 305˙000.00
6    UNIVERSITAT LINZ AT (LINZ) participant 285˙250.00
7    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 279˙250.00
8    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 272˙250.00

Map

 Project objective

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required. LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.

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The information about "LION-HEARTED" are provided by the European Opendata Portal: CORDIS opendata.

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