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LION-HEARTED SIGNED

Light and Organic Nanotechnology for Cardiovascular Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 LION-HEARTED project word cloud

Explore the words cloud of the LION-HEARTED project. It provides you a very rough idea of what is the project "LION-HEARTED" about.

virtually    light    proof    life    stenosis    quality    pharmaceutical    point    vivo    animal    therapies    invasive    phenotype    unprecedented    mortality    respect    systemic    molecular    reparative    resident    vascularization    unfortunately    transplantation    consequence    disease    circulating    cell    incidence    dependence    worldwide    urgently    homing    aneurysm    repair    proliferation    lacking    platform    phototransducers    poor    models    survival    types    disorders    givers    cardiovascular    modulation    ischemic    breakthrough    preserve    semiconductors    function    rescue    lion    population    modulating    efficient    treatment    outcome    economical    organic    device    stage    reverse    spatio    daily    nanotechnology    act    insult    care    pharmacological    possibility    minimally    temporal    aging    progenitors    synergistic    patients    combination    heart    resolution    realization    gene    restore    strategy    displays    optical    lower    trigger    disruption    endothelial    morbidity    implantable    huge    biocompatible    blood    negative    electrical    socio    invasiveness    fate    final    selectivity    least    hf    circumvent    cells    optoceutic    greatest    hearted    cv    cardiac    perfusion    hurdles    efficacy    stimulating    limiting    biological    cardiomyocytes    progression   

Project "LION-HEARTED" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙904˙413 €
 EC max contribution 2˙904˙413 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 509˙458.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 489˙730.00
3    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 450˙000.00
4    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 313˙475.00
5    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 305˙000.00
6    UNIVERSITAT LINZ AT (LINZ) participant 285˙250.00
7    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 279˙250.00
8    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 272˙250.00

Map

 Project objective

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required. LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.

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The information about "LION-HEARTED" are provided by the European Opendata Portal: CORDIS opendata.

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