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LION-HEARTED SIGNED

Light and Organic Nanotechnology for Cardiovascular Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 LION-HEARTED project word cloud

Explore the words cloud of the LION-HEARTED project. It provides you a very rough idea of what is the project "LION-HEARTED" about.

systemic    biocompatible    possibility    selectivity    dependence    progenitors    optical    vivo    care    consequence    stage    poor    nanotechnology    reverse    daily    models    animal    morbidity    molecular    greatest    act    negative    phenotype    final    huge    disruption    proliferation    gene    hurdles    modulating    population    life    spatio    synergistic    cardiovascular    mortality    cardiac    virtually    givers    progression    optoceutic    least    biological    phototransducers    resident    modulation    resolution    combination    realization    invasiveness    cell    unprecedented    repair    unfortunately    cv    device    economical    quality    blood    lion    organic    socio    breakthrough    circumvent    electrical    efficacy    implantable    platform    urgently    reparative    worldwide    hearted    aging    hf    respect    efficient    outcome    vascularization    cardiomyocytes    circulating    preserve    types    treatment    aneurysm    fate    perfusion    patients    pharmaceutical    lacking    survival    temporal    cells    homing    function    stenosis    incidence    light    endothelial    minimally    disorders    restore    therapies    proof    insult    limiting    rescue    stimulating    transplantation    pharmacological    disease    displays    invasive    point    heart    lower    ischemic    semiconductors    trigger    strategy   

Project "LION-HEARTED" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙904˙413 €
 EC max contribution 2˙904˙413 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 509˙458.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 489˙730.00
3    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 450˙000.00
4    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 313˙475.00
5    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 305˙000.00
6    UNIVERSITAT LINZ AT (LINZ) participant 285˙250.00
7    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 279˙250.00
8    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 272˙250.00

Map

 Project objective

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required. LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.

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The information about "LION-HEARTED" are provided by the European Opendata Portal: CORDIS opendata.

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