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LION-HEARTED SIGNED

Light and Organic Nanotechnology for Cardiovascular Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 LION-HEARTED project word cloud

Explore the words cloud of the LION-HEARTED project. It provides you a very rough idea of what is the project "LION-HEARTED" about.

phototransducers    disease    economical    nanotechnology    life    vivo    reverse    insult    systemic    stage    respect    semiconductors    modulation    trigger    stenosis    phenotype    disruption    consequence    modulating    cardiovascular    urgently    outcome    pharmaceutical    rescue    resolution    patients    hearted    worldwide    pharmacological    perfusion    quality    efficient    population    poor    resident    heart    endothelial    realization    limiting    point    therapies    combination    daily    circulating    cell    ischemic    breakthrough    aging    animal    act    blood    reparative    function    incidence    gene    restore    proliferation    cv    biocompatible    aneurysm    organic    device    homing    efficacy    negative    transplantation    preserve    cardiac    proof    disorders    lower    huge    progression    implantable    repair    survival    models    selectivity    biological    mortality    final    vascularization    unprecedented    displays    invasiveness    circumvent    platform    temporal    light    spatio    lion    fate    stimulating    cells    lacking    care    least    givers    minimally    possibility    optoceutic    hurdles    hf    invasive    cardiomyocytes    morbidity    treatment    dependence    synergistic    optical    virtually    unfortunately    electrical    greatest    progenitors    molecular    strategy    types    socio   

Project "LION-HEARTED" data sheet

The following table provides information about the project.

Coordinator		 FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 2˙904˙413 €
 EC max contribution 2˙904˙413 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 509˙458.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 489˙730.00
3    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 450˙000.00
4    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 313˙475.00
5    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 305˙000.00
6    UNIVERSITAT LINZ AT (LINZ) participant 285˙250.00
7    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 279˙250.00
8    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 272˙250.00

Map

 Project objective

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required. LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.

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The information about "LION-HEARTED" are provided by the European Opendata Portal: CORDIS opendata.

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