Opendata, web and dolomites


Navigating lymphatic formation and function in health and disease

Total Cost €


EC-Contrib. €






 LymphMap project word cloud

Explore the words cloud of the LymphMap project. It provides you a very rough idea of what is the project "LymphMap" about.

levels    peripheral    diversity    clinical    lymphmap    transform    organs    cross    profiling    human    of    expression    morphogenesis    adult    structure    longer    disease    multiple    line    underlying    specialization    cellular    resolution    specification    antigens    heterogeneous    endothelium    events    perceiving    tissues    contributed    highlighting    fluid    inert    lymphoid    convenient    origins    reevaluation    decade    vessels    vessel    cells    zebrafish    imaging    directions    regeneration    lymphatic    viewed    carry    zf    organ    experimental    orchestrators    paradigm    regulatory    achievements    mechanisms    characterizing    flow    organotypic    vivo    for    tissue    involvement    models    discoveries    anticipate    settings    equally    strategy    bystanders    reveal    biology    model    functions    signature    global    proteins    lymphatics    embryo    conduits    health    endothelial    passive    coordinate    dynamics    lecs    combination    molecular   

Project "LymphMap" data sheet

The following table provides information about the project.


Organization address
address: HERZL STREET 234
postcode: 7610001

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00


 Project objective

For many years, lymphatic vessels have been viewed as inert fluid conduits whose open structure allows for passive flow of antigens, proteins and cells from peripheral tissues to lymphoid organs. Yet, recent discoveries highlighting novel functions and heterogeneous origins of the lymphatic endothelium, call for reevaluation of the passive lymphatic-vessel paradigm. During the past decade, we have used the zebrafish (ZF) to detail the cellular and molecular events underlying the development of the lymphatic system. Our discoveries have greatly contributed to our understanding of the origins, specification and mechanisms of formation of lymphatic endothelial cells (LECs) in the developing embryo. In line with our past achievements, we now aim towards novel directions- to transform the adult ZF into an equally convenient model for the study of lymphatic diversity. The overall goal of LymphMap is to reveal the multiple regulatory levels that coordinate the formation and functionality of lymphatic vessels in health and disease. To this end, we will carry out a comprehensive research program characterizing four distinct aspects of lymphatic biology: 1.Cellular origins and molecular signature of LECs 2.Formation and specialization of organotypic lymphatics 3.Lymphatic vessels during organ regeneration 4.Lymphatic involvement in human disease Our experimental strategy involves the combination of high-resolution imaging, global expression profiling and regeneration models in adult ZF, with analyses of human-derived LECs in various clinical settings. The important and unique aspects of our approach are the focus on in vivo dynamics, and the cross-organ comparative analysis, which will likely provide the much-needed knowledge on lymphatic diversity in health and disease. When completed, we anticipate that this work will be part of a new paradigm – no longer perceiving lymphatics as passive bystanders, but rather as orchestrators of tissue morphogenesis and regeneration.

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The information about "LYMPHMAP" are provided by the European Opendata Portal: CORDIS opendata.

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