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EpiCrest2Reg SIGNED

From Epigenetics of Cranial Neural Crest Plasticity to Intervertebral Disc Regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 EpiCrest2Reg project word cloud

Explore the words cloud of the EpiCrest2Reg project. It provides you a very rough idea of what is the project "EpiCrest2Reg" about.

cues    lack    scientific    degeneration    structures    rna    fundamental    underlying    progenitor    paradigm    ivd    epigenetic    hox    appropriate    positive    synergies    human    models    seq    chromatin    cnccs    regeneration    clinical    bioreactor    genetics    molecular    demonstrated    types    organ    cartilage    share    epigenetically    embryonic    co    mechanisms    nasal    competence    found    adapt    silent    crest    chondrocytes    broad    disc    signals    chip    cncc    heterotopic    bone    until    architectures    genes    biological    bridging    single    environment    articular    repair    medicine    cell    adult    environmental    position    autologous    plasticity    active    cranial    ncs    responsible    developmental    culture    trial    capacity    craniofacial    signature    intervertebral    degenerated    neural    cells    patterning    assays    poised    verify    sources    transcriptomes    regenerative    shown    epigenomes    local    epi    switched    capture    source    hic    transcriptionally    during    larger    sites    limits    subpopulations    3d    readily    maintains    negative   

Project "EpiCrest2Reg" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 5˙330˙000 €
 EC max contribution 5˙330˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙670˙000.00
2    UNIVERSITAT BASEL CH (BASEL) participant 2˙660˙000.00

Map

 Project objective

During craniofacial development, Cranial Neural Crest Cells (CNCCs) maintain broad plasticity and patterning competence until they make appropriate cartilage and bone structures in response to local cues. We found that CNCC embryonic plasticity involves a specific epigenetic chromatin signature that maintains genes, including Hox genes, in a transcriptionally silent but poised state, so that they can be readily switched to an active state in response to position-specific environmental signals. Are there CNCC-derived subpopulations in the adult face cartilage with similar broad plasticity properties that could be used as progenitor source in regenerative medicine? We have shown that Hox-negative adult human CNCC-derived Nasal Chondrocytes (NCs) have cartilage regenerative capacity and plasticity to adapt to heterotopic sites larger than other cell sources, and demonstrated their potential clinical use for articular cartilage repair.

However, lack of understanding of the involved molecular mechanisms limits the broader utilization of adult NCs for the regeneration of other cartilage types, e.g. the intervertebral disc (IVD). This proposal will establish fundamental understanding of the biological processes responsible for the plasticity of adult human NCs and offer a paradigm example of scientific and clinical synergies bridging developmental (epi)genetics and regenerative medicine.

We will: • Establish whether Hox-negative adult NCs and embryonic CNCCs share similar transcriptomes, epigenomes and 3D chromatin architectures using single cell RNA-seq, ChIP-seq and capture HiC-seq assays. • Assess whether NCs can epigenetically and transcriptionally adapt to the Hox-positive IVD environment, using co-culture and bioreactor-based organ culture models, and investigate the underlying molecular mechanisms. • Verify the capacity of adult NCs to repair degenerated IVD cartilage. • Use human autologous NCs for repair of IVD degeneration in a phase I clinical trial.

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The information about "EPICREST2REG" are provided by the European Opendata Portal: CORDIS opendata.

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