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EpiCrest2Reg SIGNED

From Epigenetics of Cranial Neural Crest Plasticity to Intervertebral Disc Regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 EpiCrest2Reg project word cloud

Explore the words cloud of the EpiCrest2Reg project. It provides you a very rough idea of what is the project "EpiCrest2Reg" about.

local    bridging    adult    neural    cues    structures    mechanisms    models    shown    repair    limits    signals    organ    readily    human    medicine    patterning    found    cranial    epigenetically    regenerative    lack    share    until    clinical    developmental    intervertebral    source    demonstrated    bone    cncc    single    paradigm    craniofacial    chip    progenitor    environment    3d    degenerated    positive    ivd    crest    chromatin    seq    plasticity    subpopulations    autologous    adapt    responsible    epigenetic    fundamental    maintains    hic    appropriate    underlying    during    rna    environmental    capture    competence    regeneration    silent    trial    cartilage    epi    embryonic    cells    larger    hox    cell    verify    synergies    genetics    co    types    ncs    architectures    chondrocytes    signature    broad    sites    negative    position    culture    scientific    capacity    cnccs    transcriptomes    genes    heterotopic    degeneration    switched    active    biological    molecular    poised    transcriptionally    bioreactor    disc    articular    sources    assays    epigenomes    nasal   

Project "EpiCrest2Reg" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 5˙330˙000 €
 EC max contribution 5˙330˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙670˙000.00
2    UNIVERSITAT BASEL CH (BASEL) participant 2˙660˙000.00

Map

 Project objective

During craniofacial development, Cranial Neural Crest Cells (CNCCs) maintain broad plasticity and patterning competence until they make appropriate cartilage and bone structures in response to local cues. We found that CNCC embryonic plasticity involves a specific epigenetic chromatin signature that maintains genes, including Hox genes, in a transcriptionally silent but poised state, so that they can be readily switched to an active state in response to position-specific environmental signals. Are there CNCC-derived subpopulations in the adult face cartilage with similar broad plasticity properties that could be used as progenitor source in regenerative medicine? We have shown that Hox-negative adult human CNCC-derived Nasal Chondrocytes (NCs) have cartilage regenerative capacity and plasticity to adapt to heterotopic sites larger than other cell sources, and demonstrated their potential clinical use for articular cartilage repair.

However, lack of understanding of the involved molecular mechanisms limits the broader utilization of adult NCs for the regeneration of other cartilage types, e.g. the intervertebral disc (IVD). This proposal will establish fundamental understanding of the biological processes responsible for the plasticity of adult human NCs and offer a paradigm example of scientific and clinical synergies bridging developmental (epi)genetics and regenerative medicine.

We will: • Establish whether Hox-negative adult NCs and embryonic CNCCs share similar transcriptomes, epigenomes and 3D chromatin architectures using single cell RNA-seq, ChIP-seq and capture HiC-seq assays. • Assess whether NCs can epigenetically and transcriptionally adapt to the Hox-positive IVD environment, using co-culture and bioreactor-based organ culture models, and investigate the underlying molecular mechanisms. • Verify the capacity of adult NCs to repair degenerated IVD cartilage. • Use human autologous NCs for repair of IVD degeneration in a phase I clinical trial.

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The information about "EPICREST2REG" are provided by the European Opendata Portal: CORDIS opendata.

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