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AgePhagy SIGNED

An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AgePhagy project word cloud

Explore the words cloud of the AgePhagy project. It provides you a very rough idea of what is the project "AgePhagy" about.

accurately    outputs    population    assure    anti    grant    business    connecting    dna    compounds    societal    collaborate    industrial    final    model    shown    maximise    genetic    sought    modifier    accelerated    steeply    cells    trials    profound    modifiers    longevity    healthy    human    economic    drosophila    viability    cellular    lived    ageing    degradation    elderly    clock    designed    commercial    diseases    subtle    mutants    organisms    geroprotector    differentiates    ucl    uncover    pharmacological    vitro    drugs    detects    age    launch    collaborator    accompanying    lifespan    discovery    library    autophagy    replicating    treatment    transition    showed    ultimate    impactful    innovative    biomarker    decades    first    mimic    epigenetic    methylation    assays    rapamycin    clocks    soon    combine    primary    gsk    cancerphagy    trametinib    upregulation    instance    health    validate    cellage    drug    vivo    closely    outcome    platform    expedited    clinical   

Project "AgePhagy" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙872 €
 EC max contribution 149˙872 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙872.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project, we showed that genetic upregulation of autophagy, major cellular degradation pathway, increased lifespan, which we aim to mimic by pharmacological treatment. To this end, we developed the CellAge epigenetic clock, which is based on DNA methylation and which is the first clock that accurately detects subtle ageing changes in human primary cells in vitro upon a short anti-ageing drugs treatment, as shown using rapamycin and trametinib. This differentiates our clock from other available epigenetic clocks which are designed to accurately determine human age in years. By connecting the CellAge clock to autophagy drug library we will test the commercial viability of our anti-ageing drug assessment platform. To further validate our CellAge clock as a robust human ageing biomarker, we will combine its outputs with longevity assays in vivo in Drosophila. The final outcome will be an innovative and accelerated discovery platform for sought after anti-ageing/geroprotector drugs, which we will in this first instance test autophagy modifier drugs. Throughout the project we will closely collaborate with our industrial collaborator, GSK and UCL Business, which will assure we maximise the potential of our platform. Our ultimate goal is to uncover novel autophagy modifiers with anti-ageing properties and to launch the CellAge clock as the most advanced platform for expedited discovery of anti-ageing compounds.

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The information about "AGEPHAGY" are provided by the European Opendata Portal: CORDIS opendata.

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