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AgePhagy SIGNED

An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AgePhagy project word cloud

Explore the words cloud of the AgePhagy project. It provides you a very rough idea of what is the project "AgePhagy" about.

degradation    pharmacological    steeply    longevity    compounds    societal    age    healthy    clinical    drug    outcome    cancerphagy    assure    assays    collaborate    health    upregulation    anti    validate    human    trials    autophagy    clocks    dna    launch    soon    detects    mutants    biomarker    grant    diseases    cellular    expedited    collaborator    connecting    economic    organisms    showed    lifespan    final    differentiates    commercial    elderly    impactful    closely    instance    ageing    industrial    mimic    outputs    accurately    drugs    replicating    gsk    platform    cellage    innovative    uncover    population    ultimate    ucl    sought    first    business    lived    clock    genetic    shown    maximise    accelerated    rapamycin    profound    cells    methylation    drosophila    designed    combine    treatment    subtle    decades    trametinib    accompanying    model    discovery    modifier    library    vitro    epigenetic    geroprotector    modifiers    vivo    primary    viability    transition   

Project "AgePhagy" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙872 €
 EC max contribution 149˙872 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙872.00

Map

 Project objective

The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project, we showed that genetic upregulation of autophagy, major cellular degradation pathway, increased lifespan, which we aim to mimic by pharmacological treatment. To this end, we developed the CellAge epigenetic clock, which is based on DNA methylation and which is the first clock that accurately detects subtle ageing changes in human primary cells in vitro upon a short anti-ageing drugs treatment, as shown using rapamycin and trametinib. This differentiates our clock from other available epigenetic clocks which are designed to accurately determine human age in years. By connecting the CellAge clock to autophagy drug library we will test the commercial viability of our anti-ageing drug assessment platform. To further validate our CellAge clock as a robust human ageing biomarker, we will combine its outputs with longevity assays in vivo in Drosophila. The final outcome will be an innovative and accelerated discovery platform for sought after anti-ageing/geroprotector drugs, which we will in this first instance test autophagy modifier drugs. Throughout the project we will closely collaborate with our industrial collaborator, GSK and UCL Business, which will assure we maximise the potential of our platform. Our ultimate goal is to uncover novel autophagy modifiers with anti-ageing properties and to launch the CellAge clock as the most advanced platform for expedited discovery of anti-ageing compounds.

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The information about "AGEPHAGY" are provided by the European Opendata Portal: CORDIS opendata.

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