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AgePhagy SIGNED

An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AgePhagy project word cloud

Explore the words cloud of the AgePhagy project. It provides you a very rough idea of what is the project "AgePhagy" about.

elderly    subtle    compounds    rapamycin    clinical    detects    epigenetic    population    health    uncover    showed    drosophila    dna    accurately    treatment    gsk    methylation    library    validate    collaborate    vitro    cellage    clock    mimic    healthy    innovative    combine    cancerphagy    human    assure    decades    trials    organisms    launch    ageing    model    maximise    differentiates    economic    outcome    business    vivo    pharmacological    autophagy    connecting    age    transition    final    first    platform    cells    designed    impactful    soon    accompanying    discovery    societal    profound    shown    modifiers    accelerated    industrial    instance    assays    diseases    outputs    upregulation    ucl    closely    lifespan    drug    biomarker    expedited    sought    cellular    trametinib    clocks    modifier    viability    ultimate    genetic    replicating    lived    collaborator    degradation    commercial    grant    primary    drugs    mutants    anti    steeply    longevity    geroprotector   

Project "AgePhagy" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙872 €
 EC max contribution 149˙872 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙872.00

Map

 Project objective

The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project, we showed that genetic upregulation of autophagy, major cellular degradation pathway, increased lifespan, which we aim to mimic by pharmacological treatment. To this end, we developed the CellAge epigenetic clock, which is based on DNA methylation and which is the first clock that accurately detects subtle ageing changes in human primary cells in vitro upon a short anti-ageing drugs treatment, as shown using rapamycin and trametinib. This differentiates our clock from other available epigenetic clocks which are designed to accurately determine human age in years. By connecting the CellAge clock to autophagy drug library we will test the commercial viability of our anti-ageing drug assessment platform. To further validate our CellAge clock as a robust human ageing biomarker, we will combine its outputs with longevity assays in vivo in Drosophila. The final outcome will be an innovative and accelerated discovery platform for sought after anti-ageing/geroprotector drugs, which we will in this first instance test autophagy modifier drugs. Throughout the project we will closely collaborate with our industrial collaborator, GSK and UCL Business, which will assure we maximise the potential of our platform. Our ultimate goal is to uncover novel autophagy modifiers with anti-ageing properties and to launch the CellAge clock as the most advanced platform for expedited discovery of anti-ageing compounds.

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The information about "AGEPHAGY" are provided by the European Opendata Portal: CORDIS opendata.

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