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COLIBRI SIGNED

Click chemistry Options for Live Immuno Brain Imaging

Total Cost €

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EC-Contrib. €

0

Partnership

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 COLIBRI project word cloud

Explore the words cloud of the COLIBRI project. It provides you a very rough idea of what is the project "COLIBRI" about.

as    binding    context    supervision    tco    union    techniques    trans    synthesis    derivatization    usefulness    communication    brain    age    scientific    immuno    investigation    optimal    neurodegenerative    alpha    students    meetings    training    budget    vivo    popularization    courses    rest    blocking    monitoring    exists    versatile    global    tzab    pretargeted    translational    nd    flow    internet    animal    larger    publications    derivative    date    issue    packages    risk    world    pretargeting    18    efficacy    ex    labelled    click    micropet    radiochemistry    reaction    interdisciplinary    models    parkinson    ethics    disease    organic    polar    tests    progress    realized    alzheimer    lab    diagnosis    career    plan    evaluation    colibri    therapies    fluorine    pet    braintco    peripheral    conferences    events    covered    personal    molecular    reports    living    derivatives    diseases    imaging    synuclein    18f    clearance    chemistry    mr    antibody    population    vitro    follow    fellowship    longer    autoradiography    tetrazine    cyclooctene    divided    kinetics    cure   

Project "COLIBRI" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-23   to  2021-04-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 166˙320.00

Map

 Project objective

As the world’s population is living longer, age-related neurodegenerative diseases (ND) such as Alzheimer’s and Parkinson’s are becoming a larger global issue. To date, no cure exists, and the European Union considers the understanding and the diagnosis of ND as key research areas. In this context, the overall aim of the fellowship is the development of a versatile method for immuno based brain PET, as a general translational molecular research method that can also be applied for early diagnosis of ND and follow up of the efficacy of novel ND therapies. This will be realized through a pretargeting approach using in vivo click chemistry in brain. More specifically, I will investigate the usefulness of 18F-TCO (trans-cyclooctene derivatives) for pretargeted PET imaging of α-synuclein for Parkinson’s disease. The project will be divided into 4 objectives: (1) Design and synthesis of fluorine-18 labelled TCO derivatives with optimal brain uptake and clearance (“18F-brainTCO”), (2) Evaluation of in vivo kinetics of a polar peripheral blocking TCO derivative, (3) Tetrazine derivatization of an antibody (TzAb) targeting α-synuclein, investigation of in vitro and in vivo binding to α-synuclein, and in vitro and in vivo availability for click reaction, (4) In vitro (autoradiography) and in vivo (microPET/MR) imaging of the TzAb binding to α-synuclein using 18F-brainTCO. The success of COLIBRI will rest on its interdisciplinary since various scientific fields will be covered: organic synthesis, flow chemistry, antibody derivatization, radiochemistry, in vitro/ex vivo tests, in vivo tests in animal models and PET imaging. The project also includes work packages dedicated to the project management (personal career development plan, progress monitoring, budget, ethics and risk management), training (techniques, courses, supervision of students), and dissemination and communication (publications, reports, lab meetings, conferences, popularization events, Internet presence, ...).

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The information about "COLIBRI" are provided by the European Opendata Portal: CORDIS opendata.

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