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COLIBRI SIGNED

Click chemistry Options for Live Immuno Brain Imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COLIBRI project word cloud

Explore the words cloud of the COLIBRI project. It provides you a very rough idea of what is the project "COLIBRI" about.

synuclein    disease    packages    larger    polar    progress    tzab    publications    antibody    longer    supervision    chemistry    date    context    age    nd    tests    derivatives    mr    pet    derivative    techniques    scientific    living    optimal    pretargeted    ethics    population    click    as    divided    18    budget    cure    monitoring    courses    career    translational    exists    labelled    pretargeting    18f    organic    blocking    brain    follow    reports    ex    diagnosis    models    flow    events    world    students    risk    popularization    peripheral    derivatization    molecular    rest    immuno    neurodegenerative    realized    covered    synthesis    clearance    conferences    alpha    animal    radiochemistry    interdisciplinary    tetrazine    therapies    meetings    fluorine    lab    colibri    imaging    internet    vivo    alzheimer    investigation    parkinson    plan    reaction    trans    diseases    usefulness    versatile    micropet    autoradiography    kinetics    union    global    vitro    communication    tco    binding    braintco    training    issue    personal    fellowship    efficacy    evaluation    cyclooctene   

Project "COLIBRI" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-23   to  2021-04-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 166˙320.00

Map

 Project objective

As the world’s population is living longer, age-related neurodegenerative diseases (ND) such as Alzheimer’s and Parkinson’s are becoming a larger global issue. To date, no cure exists, and the European Union considers the understanding and the diagnosis of ND as key research areas. In this context, the overall aim of the fellowship is the development of a versatile method for immuno based brain PET, as a general translational molecular research method that can also be applied for early diagnosis of ND and follow up of the efficacy of novel ND therapies. This will be realized through a pretargeting approach using in vivo click chemistry in brain. More specifically, I will investigate the usefulness of 18F-TCO (trans-cyclooctene derivatives) for pretargeted PET imaging of α-synuclein for Parkinson’s disease. The project will be divided into 4 objectives: (1) Design and synthesis of fluorine-18 labelled TCO derivatives with optimal brain uptake and clearance (“18F-brainTCO”), (2) Evaluation of in vivo kinetics of a polar peripheral blocking TCO derivative, (3) Tetrazine derivatization of an antibody (TzAb) targeting α-synuclein, investigation of in vitro and in vivo binding to α-synuclein, and in vitro and in vivo availability for click reaction, (4) In vitro (autoradiography) and in vivo (microPET/MR) imaging of the TzAb binding to α-synuclein using 18F-brainTCO. The success of COLIBRI will rest on its interdisciplinary since various scientific fields will be covered: organic synthesis, flow chemistry, antibody derivatization, radiochemistry, in vitro/ex vivo tests, in vivo tests in animal models and PET imaging. The project also includes work packages dedicated to the project management (personal career development plan, progress monitoring, budget, ethics and risk management), training (techniques, courses, supervision of students), and dissemination and communication (publications, reports, lab meetings, conferences, popularization events, Internet presence, ...).

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The information about "COLIBRI" are provided by the European Opendata Portal: CORDIS opendata.

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