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COLIBRI SIGNED

Click chemistry Options for Live Immuno Brain Imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COLIBRI project word cloud

Explore the words cloud of the COLIBRI project. It provides you a very rough idea of what is the project "COLIBRI" about.

antibody    events    organic    usefulness    evaluation    imaging    braintco    publications    derivative    internet    optimal    parkinson    population    exists    therapies    diagnosis    date    personal    training    vivo    radiochemistry    scientific    nd    issue    reaction    realized    union    divided    world    conferences    budget    fellowship    click    neurodegenerative    tco    plan    alpha    polar    supervision    context    brain    courses    clearance    ethics    cyclooctene    interdisciplinary    kinetics    trans    as    mr    covered    living    colibri    versatile    vitro    global    pretargeted    longer    students    larger    fluorine    tests    tetrazine    techniques    chemistry    peripheral    communication    monitoring    autoradiography    progress    pet    career    labelled    binding    cure    risk    18f    tzab    diseases    blocking    packages    popularization    models    meetings    disease    flow    age    synuclein    pretargeting    18    ex    alzheimer    synthesis    micropet    rest    efficacy    investigation    molecular    derivatives    animal    follow    immuno    reports    derivatization    translational    lab   

Project "COLIBRI" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-23   to  2021-04-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 166˙320.00

Map

 Project objective

As the world’s population is living longer, age-related neurodegenerative diseases (ND) such as Alzheimer’s and Parkinson’s are becoming a larger global issue. To date, no cure exists, and the European Union considers the understanding and the diagnosis of ND as key research areas. In this context, the overall aim of the fellowship is the development of a versatile method for immuno based brain PET, as a general translational molecular research method that can also be applied for early diagnosis of ND and follow up of the efficacy of novel ND therapies. This will be realized through a pretargeting approach using in vivo click chemistry in brain. More specifically, I will investigate the usefulness of 18F-TCO (trans-cyclooctene derivatives) for pretargeted PET imaging of α-synuclein for Parkinson’s disease. The project will be divided into 4 objectives: (1) Design and synthesis of fluorine-18 labelled TCO derivatives with optimal brain uptake and clearance (“18F-brainTCO”), (2) Evaluation of in vivo kinetics of a polar peripheral blocking TCO derivative, (3) Tetrazine derivatization of an antibody (TzAb) targeting α-synuclein, investigation of in vitro and in vivo binding to α-synuclein, and in vitro and in vivo availability for click reaction, (4) In vitro (autoradiography) and in vivo (microPET/MR) imaging of the TzAb binding to α-synuclein using 18F-brainTCO. The success of COLIBRI will rest on its interdisciplinary since various scientific fields will be covered: organic synthesis, flow chemistry, antibody derivatization, radiochemistry, in vitro/ex vivo tests, in vivo tests in animal models and PET imaging. The project also includes work packages dedicated to the project management (personal career development plan, progress monitoring, budget, ethics and risk management), training (techniques, courses, supervision of students), and dissemination and communication (publications, reports, lab meetings, conferences, popularization events, Internet presence, ...).

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The information about "COLIBRI" are provided by the European Opendata Portal: CORDIS opendata.

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