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COLIBRI SIGNED

Click chemistry Options for Live Immuno Brain Imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COLIBRI project word cloud

Explore the words cloud of the COLIBRI project. It provides you a very rough idea of what is the project "COLIBRI" about.

labelled    diagnosis    realized    reaction    optimal    popularization    world    pretargeted    students    braintco    cure    nd    autoradiography    chemistry    fluorine    animal    longer    date    internet    parkinson    living    pet    global    efficacy    communication    techniques    tetrazine    synthesis    polar    fellowship    mr    micropet    publications    issue    packages    ex    budget    personal    follow    ethics    investigation    union    reports    tests    pretargeting    immuno    scientific    peripheral    population    age    brain    alpha    context    larger    lab    binding    interdisciplinary    organic    synuclein    progress    cyclooctene    vitro    training    covered    models    derivatization    flow    kinetics    vivo    18f    as    diseases    risk    derivative    meetings    exists    alzheimer    click    events    colibri    tzab    antibody    translational    plan    disease    courses    tco    divided    therapies    trans    derivatives    neurodegenerative    usefulness    molecular    conferences    imaging    supervision    clearance    rest    blocking    monitoring    evaluation    radiochemistry    career    versatile    18   

Project "COLIBRI" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-23   to  2021-04-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 166˙320.00

Map

 Project objective

As the world’s population is living longer, age-related neurodegenerative diseases (ND) such as Alzheimer’s and Parkinson’s are becoming a larger global issue. To date, no cure exists, and the European Union considers the understanding and the diagnosis of ND as key research areas. In this context, the overall aim of the fellowship is the development of a versatile method for immuno based brain PET, as a general translational molecular research method that can also be applied for early diagnosis of ND and follow up of the efficacy of novel ND therapies. This will be realized through a pretargeting approach using in vivo click chemistry in brain. More specifically, I will investigate the usefulness of 18F-TCO (trans-cyclooctene derivatives) for pretargeted PET imaging of α-synuclein for Parkinson’s disease. The project will be divided into 4 objectives: (1) Design and synthesis of fluorine-18 labelled TCO derivatives with optimal brain uptake and clearance (“18F-brainTCO”), (2) Evaluation of in vivo kinetics of a polar peripheral blocking TCO derivative, (3) Tetrazine derivatization of an antibody (TzAb) targeting α-synuclein, investigation of in vitro and in vivo binding to α-synuclein, and in vitro and in vivo availability for click reaction, (4) In vitro (autoradiography) and in vivo (microPET/MR) imaging of the TzAb binding to α-synuclein using 18F-brainTCO. The success of COLIBRI will rest on its interdisciplinary since various scientific fields will be covered: organic synthesis, flow chemistry, antibody derivatization, radiochemistry, in vitro/ex vivo tests, in vivo tests in animal models and PET imaging. The project also includes work packages dedicated to the project management (personal career development plan, progress monitoring, budget, ethics and risk management), training (techniques, courses, supervision of students), and dissemination and communication (publications, reports, lab meetings, conferences, popularization events, Internet presence, ...).

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The information about "COLIBRI" are provided by the European Opendata Portal: CORDIS opendata.

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