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Engineering of complex protocells by micro-compartmentalization of living bacteria

Total Cost €


EC-Contrib. €






 PROTOBAC project word cloud

Explore the words cloud of the PROTOBAC project. It provides you a very rough idea of what is the project "PROTOBAC" about.

cellular    active    nuclear    physical    forms    functionally    question    engineering    multidisciplinary    lipids    organization    protocell    metabolic    professor    stephen    introducing    mann    lack    assemblage    biotechnology    organelles    sensing    internally    transduction    starting    components    last    answer    materials    capacity    hosting    genetic    few    group    energy    living    outcome    gene    bound    transition    segregation    microbiology    first    sequestration    efforts    protocells    frs    suitable    expertise    bristol    functions    plasmids    metabolism    construction    loaded    replication    exhibiting    rudimentary    bacterial    disruption    membrane    pioneering    organisational    functional    colonies    synthesis    mitochondria    inanimate    instead    spatial    bacteria    perform    life    biological    biology    minimal    material    compartmentalization    university    artificial    behaviours    expression    synthetic    complexity    structural    precisely    compartmentalized    protoeukaryote    designs    manifestations    proto    endomembrane    combined   

Project "PROTOBAC" data sheet

The following table provides information about the project.


Organization address
postcode: BS8 1QU

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00


 Project objective

The engineering of artificial cellular systems (i.e. protocells) exhibiting rudimentary life-like properties, such as minimal metabolism, sensing or replication, gene expression and compartmentalization, represents the most suitable path to undertake to answer the important question on how inanimate systems can transition into proto-living manifestations of physical matter. However, most of the current protocell designs still lack the structural and organisational complexity required for them to perform advanced functions and behaviours. Instead of starting from non-living materials, the aim of this proposal is precisely to design and construction of complex multi-component protocells based on the controlled sequestration and disruption of compartmentalized living bacterial colonies. The result protocells will bound by an assemblage of bacterial membrane lipids and internally loaded with a large number of functionally active metabolic and genetic components. Furthermore, the structural and functional complexity of the bacteria-derived protocells will be increased by introducing several important biological organelles such as proto-nuclear, proto-mitochondria components and endomembrane system, which is expected to produce the first example of protoeukaryote. The previous expertise of the applicant in the field of biotechnology, synthetic biology and microbiology will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bacteria derived protocells and develop their advanced forms capable of increased energy (metabolic) capacity and transduction, spatial segregation of genetic material (plasmids etc), and higher-order organization and processing.

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The information about "PROTOBAC" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-18 4:52:18) correctly updated