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PROTOBAC SIGNED

Engineering of complex protocells by micro-compartmentalization of living bacteria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PROTOBAC project word cloud

Explore the words cloud of the PROTOBAC project. It provides you a very rough idea of what is the project "PROTOBAC" about.

hosting    engineering    living    bacterial    expression    designs    life    energy    last    biology    colonies    functional    sequestration    exhibiting    materials    functions    suitable    outcome    material    cellular    functionally    university    behaviours    replication    biotechnology    bound    pioneering    introducing    internally    organelles    physical    mann    bacteria    first    protocells    protocell    precisely    protoeukaryote    inanimate    lipids    metabolic    endomembrane    membrane    biological    synthetic    plasmids    stephen    minimal    compartmentalization    proto    disruption    loaded    expertise    capacity    perform    complexity    segregation    answer    assemblage    gene    nuclear    rudimentary    mitochondria    manifestations    combined    transition    metabolism    organisational    structural    starting    question    lack    organization    construction    active    microbiology    genetic    transduction    group    professor    forms    synthesis    instead    spatial    efforts    sensing    bristol    few    components    frs    compartmentalized    multidisciplinary    artificial   

Project "PROTOBAC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00

Map

 Project objective

The engineering of artificial cellular systems (i.e. protocells) exhibiting rudimentary life-like properties, such as minimal metabolism, sensing or replication, gene expression and compartmentalization, represents the most suitable path to undertake to answer the important question on how inanimate systems can transition into proto-living manifestations of physical matter. However, most of the current protocell designs still lack the structural and organisational complexity required for them to perform advanced functions and behaviours. Instead of starting from non-living materials, the aim of this proposal is precisely to design and construction of complex multi-component protocells based on the controlled sequestration and disruption of compartmentalized living bacterial colonies. The result protocells will bound by an assemblage of bacterial membrane lipids and internally loaded with a large number of functionally active metabolic and genetic components. Furthermore, the structural and functional complexity of the bacteria-derived protocells will be increased by introducing several important biological organelles such as proto-nuclear, proto-mitochondria components and endomembrane system, which is expected to produce the first example of protoeukaryote. The previous expertise of the applicant in the field of biotechnology, synthetic biology and microbiology will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bacteria derived protocells and develop their advanced forms capable of increased energy (metabolic) capacity and transduction, spatial segregation of genetic material (plasmids etc), and higher-order organization and processing.

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The information about "PROTOBAC" are provided by the European Opendata Portal: CORDIS opendata.

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