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PROTOBAC SIGNED

Engineering of complex protocells by micro-compartmentalization of living bacteria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PROTOBAC project word cloud

Explore the words cloud of the PROTOBAC project. It provides you a very rough idea of what is the project "PROTOBAC" about.

pioneering    inanimate    metabolic    protocell    disruption    question    mitochondria    nuclear    expression    life    group    sensing    organization    synthesis    bacteria    lipids    stephen    first    synthetic    answer    manifestations    instead    precisely    compartmentalized    capacity    few    compartmentalization    endomembrane    university    artificial    biotechnology    last    functional    functionally    mann    gene    suitable    proto    structural    professor    bound    replication    exhibiting    efforts    engineering    microbiology    bristol    combined    biology    segregation    hosting    introducing    multidisciplinary    active    bacterial    functions    cellular    colonies    membrane    biological    expertise    frs    outcome    perform    lack    starting    sequestration    behaviours    rudimentary    protocells    internally    protoeukaryote    assemblage    energy    living    physical    transduction    complexity    material    metabolism    components    designs    genetic    organisational    spatial    minimal    construction    plasmids    loaded    transition    materials    forms    organelles   

Project "PROTOBAC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00

Map

 Project objective

The engineering of artificial cellular systems (i.e. protocells) exhibiting rudimentary life-like properties, such as minimal metabolism, sensing or replication, gene expression and compartmentalization, represents the most suitable path to undertake to answer the important question on how inanimate systems can transition into proto-living manifestations of physical matter. However, most of the current protocell designs still lack the structural and organisational complexity required for them to perform advanced functions and behaviours. Instead of starting from non-living materials, the aim of this proposal is precisely to design and construction of complex multi-component protocells based on the controlled sequestration and disruption of compartmentalized living bacterial colonies. The result protocells will bound by an assemblage of bacterial membrane lipids and internally loaded with a large number of functionally active metabolic and genetic components. Furthermore, the structural and functional complexity of the bacteria-derived protocells will be increased by introducing several important biological organelles such as proto-nuclear, proto-mitochondria components and endomembrane system, which is expected to produce the first example of protoeukaryote. The previous expertise of the applicant in the field of biotechnology, synthetic biology and microbiology will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bacteria derived protocells and develop their advanced forms capable of increased energy (metabolic) capacity and transduction, spatial segregation of genetic material (plasmids etc), and higher-order organization and processing.

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The information about "PROTOBAC" are provided by the European Opendata Portal: CORDIS opendata.

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