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MagnetoVirology SIGNED

Diamond Magnetometry: A Versatile Tool for Virology and Medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 MagnetoVirology project word cloud

Explore the words cloud of the MagnetoVirology project. It provides you a very rough idea of what is the project "MagnetoVirology" about.

fundamental    spatiotemporal    sc1    aligns    drug    demonstrating    biology    toward    sinv    oxidants    time    reactive    unparalleled    fnds    viral    infection    small    bhc    fluid    2020    limitations    nitrogen    animal    successful    probe    arthritis    model    volume    quantified    nmbp    completion    virus    host    outcome    nanotechnology    claim    depends    cellular    conclude    underscored    oxygen    dt    complicated    biotechnology    measuring    possibility    nanodiamonds    ros    potentially    virology    cells    anti    free    diamond    centers    sindbis    therapy    health    interdisciplinary    mediating    magnetometry    pharmaceutical    cell    clinical    detrimental    detecting    radicals    intend    inside    t1    fluorescent    vacancy    detection    exact    industry    elucidated    horizon    fr    programs    kinetics    synovial    deeper    collaborative    infections    diagnostics    usefulness    relaxation    opposite    species    resolution    sensitivity    interplay    patients    pathogenesis    technique    highlight    point   

Project "MagnetoVirology" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

Reactive Oxygen Species (ROS)/ free radicals (FR) in cells have a very complicated role in viral infections. While some researchers point toward their usefulness in mediating viral infections, others conclude the exact opposite and claim that there are detrimental effects. To probe deeper into virus pathogenesis and improve anti-viral therapy, cellular FR - viral infection kinetics which potentially depends on virus, cell/animal model, type of reactive species, etc. needs to be investigated with high spatiotemporal resolution. However, all the traditional methods capable of detecting FR have limitations when real-time, long-duration, high resolution measurements are to be conducted within a small sample volume (inside of a cell). Recently, diamond magnetometry was proposed to study cellular FR with unparalleled sensitivity, resolution, and the possibility of real-time long-duration measurements. In this highly interdisciplinary collaborative research, I aim to establish this technique in studying cellular FR- viral infections kinetics. As a model system I will investigate the host cell FR response upon Sindbis virus (SINV) infection with high spatiotemporal resolution. FR response will be quantified via measuring T1 relaxation time of Nitrogen Vacancy centers in fluorescent nanodiamonds (FNDs). Furthermore, I intend to highlight the potential of diamond magnetometry in clinical diagnostics and drug development by demonstrating the FR detection in synovial fluid of arthritis patients (outcome of SINV infection) and detecting cells’ FR response to anti- oxidants. Upon successful completion, I will not only have elucidated the interplay of FR and SINV infections but also underscored the potential of diamond magnetometry in fundamental virology, infection biology, clinical diagnostics and pharmaceutical industry. This research strongly aligns with two work programs within Horizon 2020 focused on health (SC1-BHC) and nanotechnology- biotechnology (DT-NMBP).

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The information about "MAGNETOVIROLOGY" are provided by the European Opendata Portal: CORDIS opendata.

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