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MagnetoVirology SIGNED

Diamond Magnetometry: A Versatile Tool for Virology and Medicine

Total Cost €

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EC-Contrib. €

0

Partnership

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 MagnetoVirology project word cloud

Explore the words cloud of the MagnetoVirology project. It provides you a very rough idea of what is the project "MagnetoVirology" about.

virology    measuring    demonstrating    2020    t1    mediating    nanotechnology    point    interplay    pharmaceutical    opposite    outcome    fluorescent    technique    depends    fnds    clinical    resolution    model    oxygen    pathogenesis    biology    dt    sinv    nitrogen    claim    reactive    detrimental    virus    synovial    cells    usefulness    limitations    sc1    completion    highlight    diagnostics    exact    sindbis    relaxation    free    time    bhc    elucidated    host    viral    therapy    quantified    fr    programs    infections    patients    horizon    vacancy    radicals    drug    toward    cellular    sensitivity    complicated    nmbp    small    conclude    collaborative    unparalleled    possibility    aligns    fundamental    species    arthritis    probe    underscored    biotechnology    magnetometry    animal    nanodiamonds    intend    anti    spatiotemporal    diamond    potentially    cell    ros    health    inside    industry    infection    oxidants    deeper    successful    fluid    detecting    detection    centers    interdisciplinary    volume    kinetics   

Project "MagnetoVirology" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

Reactive Oxygen Species (ROS)/ free radicals (FR) in cells have a very complicated role in viral infections. While some researchers point toward their usefulness in mediating viral infections, others conclude the exact opposite and claim that there are detrimental effects. To probe deeper into virus pathogenesis and improve anti-viral therapy, cellular FR - viral infection kinetics which potentially depends on virus, cell/animal model, type of reactive species, etc. needs to be investigated with high spatiotemporal resolution. However, all the traditional methods capable of detecting FR have limitations when real-time, long-duration, high resolution measurements are to be conducted within a small sample volume (inside of a cell). Recently, diamond magnetometry was proposed to study cellular FR with unparalleled sensitivity, resolution, and the possibility of real-time long-duration measurements. In this highly interdisciplinary collaborative research, I aim to establish this technique in studying cellular FR- viral infections kinetics. As a model system I will investigate the host cell FR response upon Sindbis virus (SINV) infection with high spatiotemporal resolution. FR response will be quantified via measuring T1 relaxation time of Nitrogen Vacancy centers in fluorescent nanodiamonds (FNDs). Furthermore, I intend to highlight the potential of diamond magnetometry in clinical diagnostics and drug development by demonstrating the FR detection in synovial fluid of arthritis patients (outcome of SINV infection) and detecting cells’ FR response to anti- oxidants. Upon successful completion, I will not only have elucidated the interplay of FR and SINV infections but also underscored the potential of diamond magnetometry in fundamental virology, infection biology, clinical diagnostics and pharmaceutical industry. This research strongly aligns with two work programs within Horizon 2020 focused on health (SC1-BHC) and nanotechnology- biotechnology (DT-NMBP).

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The information about "MAGNETOVIROLOGY" are provided by the European Opendata Portal: CORDIS opendata.

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