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MagnetoVirology SIGNED

Diamond Magnetometry: A Versatile Tool for Virology and Medicine

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MagnetoVirology project word cloud

Explore the words cloud of the MagnetoVirology project. It provides you a very rough idea of what is the project "MagnetoVirology" about.

collaborative    fr    biotechnology    diagnostics    opposite    pathogenesis    exact    cell    drug    pharmaceutical    inside    relaxation    cellular    model    sc1    quantified    virus    infection    conclude    free    fluorescent    outcome    infections    potentially    nanotechnology    nanodiamonds    cells    mediating    technique    bhc    reactive    radicals    therapy    anti    spatiotemporal    sensitivity    detection    aligns    patients    toward    time    unparalleled    programs    volume    t1    fnds    2020    demonstrating    fundamental    detecting    possibility    nitrogen    detrimental    sinv    kinetics    centers    sindbis    probe    viral    clinical    industry    depends    synovial    complicated    deeper    virology    measuring    intend    underscored    claim    arthritis    usefulness    small    diamond    oxygen    elucidated    limitations    magnetometry    animal    interplay    point    nmbp    interdisciplinary    successful    horizon    completion    biology    host    vacancy    ros    fluid    health    species    resolution    dt    highlight    oxidants   

Project "MagnetoVirology" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

Reactive Oxygen Species (ROS)/ free radicals (FR) in cells have a very complicated role in viral infections. While some researchers point toward their usefulness in mediating viral infections, others conclude the exact opposite and claim that there are detrimental effects. To probe deeper into virus pathogenesis and improve anti-viral therapy, cellular FR - viral infection kinetics which potentially depends on virus, cell/animal model, type of reactive species, etc. needs to be investigated with high spatiotemporal resolution. However, all the traditional methods capable of detecting FR have limitations when real-time, long-duration, high resolution measurements are to be conducted within a small sample volume (inside of a cell). Recently, diamond magnetometry was proposed to study cellular FR with unparalleled sensitivity, resolution, and the possibility of real-time long-duration measurements. In this highly interdisciplinary collaborative research, I aim to establish this technique in studying cellular FR- viral infections kinetics. As a model system I will investigate the host cell FR response upon Sindbis virus (SINV) infection with high spatiotemporal resolution. FR response will be quantified via measuring T1 relaxation time of Nitrogen Vacancy centers in fluorescent nanodiamonds (FNDs). Furthermore, I intend to highlight the potential of diamond magnetometry in clinical diagnostics and drug development by demonstrating the FR detection in synovial fluid of arthritis patients (outcome of SINV infection) and detecting cells’ FR response to anti- oxidants. Upon successful completion, I will not only have elucidated the interplay of FR and SINV infections but also underscored the potential of diamond magnetometry in fundamental virology, infection biology, clinical diagnostics and pharmaceutical industry. This research strongly aligns with two work programs within Horizon 2020 focused on health (SC1-BHC) and nanotechnology- biotechnology (DT-NMBP).

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The information about "MAGNETOVIROLOGY" are provided by the European Opendata Portal: CORDIS opendata.

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