Opendata, web and dolomites

SQSig SIGNED

Oligo-Squaramide Rigid-Rods for Artificial Transmembrane Signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SQSig project word cloud

Explore the words cloud of the SQSig project. It provides you a very rough idea of what is the project "SQSig" about.

conformational    array    functionalizing    sq    region    tail    bonded    located    direction    squaramides    form    biophysics    group    orientation    terminal    switches    create    signaling    either    fundamental    chemistry    researcher    host    bypass    transmembrane    aggregates    biological    effect    he    action    inverting    provokes    arrays    intramolecular    acquire    model    fellow    ribbons    hydrogen    biology    sqs    bilayer    oligo    endogenous    assembly    self    followed    site    opposite    hypothesize    fascinating    initiating    aligned    relay    proteins    cytosol    monomeric    coupled    scaffolded    designed    membranes    family    gpcr    cells    spectroscopic    assemble    reporter    binding    gpcrs    act    domino    valuable    expertise    ribbon    extracellular    synthetic    external    membrane    supramolecular    insertion    forming    protein    medicinal    combines    preparation    directionality    receptors    ligand    initiate    entire    oriented    copying    true    head    transmit   

Project "SQSig" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 212˙933.00

Map

 Project objective

G-protein coupled receptors (GPCRs) are transmembrane proteins that are used by cells to transmit information through their membranes; binding of a ligand to their extracellular region provokes a conformational change, initiating a biological process in the cytosol. Copying this type of signaling pathway, which is fundamental to cells and thus a key target in medicinal chemistry, is a fascinating challenge that could allow researchers to bypass endogenous signaling pathways in cells and lead to true synthetic biology. In this project we propose to exploit the self-assembly properties of squaramides (SQs) to create a relay of information through a bilayer membrane. Monomeric SQs self-assemble as head-to-tail aggregates, forming ribbons with all the SQs oriented in the same direction. We have designed a family of scaffolded oligo-SQ arrays that will form intramolecular hydrogen-bonded ribbons aligned in either one direction or the other. We hypothesize that inverting the directionality of the terminal SQ of the ribbon will initiate a domino effect that switches the orientation of the whole array. By functionalizing the terminal SQ of the oligo-SQ relay with a binding site and the opposite end with a spectroscopic reporter, followed by insertion in model membranes, we will show that binding of an external ligand to the terminal SQ switches the directionality of the entire SQ-ribbon and provokes a spectroscopic response from the reporter located at the other side of the membrane. Thus this system will act as a synthetic GPCR, able to transmit conformational information from one side of a bilayer membrane to the other. The action combines the experience of the researcher in the preparation and study of SQs with the expertise of the host group in the development of transmembrane devices. While the fellow will bring new knowledge in synthetic and supramolecular chemistry to the host group, he will acquire valuable experience in the analysis and biophysics of membranes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SQSIG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SQSIG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More